20,037 real projects from ISEF, the Canada-Wide Science Fair, JSHS and the Calgary Youth Science Fair — searchable by meaning, and filterable by fair, year, category and award.
JSHS · 2025
Parkinson's disease (PD) is a neurodegenerative disorder resulting from loss of dopamine - producing neurons in the substantia nigra. Motor symptoms include tremors, instability, and slowed…
ISEF · 2025
Biomedical Engineering
Neuroprosthetics offer more advanced functionality compared to traditional prosthetics, but their high cost and invasive procedures limit accessibility. This research focuses on developing a…
ISEF · 2025
Translational Medical Science
CTE, a progressive neurodegenerative condition from repetitive head impacts in sports, lacks preventive interventions. This research examines curcumin and CoQ10's neuroprotective effects in…
ISEF · 2025
Biomedical and Health Sciences
The therapeutic value of traditional plants in the Philippines remains underexplored. Thus, this study investigates the neuroprotective potential of Premna odorata leaf extract for Alzheimer…
ISEF · 2025
Cellular and Molecular Biology
Current underlying mechanisms to treat neurodegenerative diseases (ND) are limited due to an incomplete understanding. Tight junctions (TJ) and efflux pumps on the BBB restrict drug permeabi…
CYSF · 2025
This project explores the fascinating science behind dreams, focusing on how the brain generates them. It examines the role of sleep stages, brain activity, and neural pathways in shaping dr…
ISEF · 2025
Biomedical Engineering
Neurodegenerative diseases (NDDs), conditions characterized by damaged cell networks in the neurological system, are becoming increasingly prevalent as the global life-expectancy continually…
ISEF · 2025
Earth and Environmental Sciences
This study describes a novel species of snail in the genus Japonia (subfamily Cyclophoridae, family Cyclophoridae) discovered in Hong Kong. This species is distinguished by unique long, spoo…
JSHS · 2025
Could a personalized, portable AI tutor transform education and improve outcomes for students in disadvantaged communities? Advancements in open -source large language models (LLMs), particu…
JSHS · 2025
Rett syndrome is a devastating neurodevelopmental disorder caused by loss -of-function mutations in the MeCP2 gene. Gene therapy represents one of the most promising strategies for treating…
ISEF · 2025
Physics and Astronomy
The possible existence of sub-solar mass black holes poses a challenge to current models of stellar evolution, as there is no known formation mechanism to produce such objects. There is some…
ISEF · 2025
Translational Medical Science
The widespread use of drugs, together with their limited specificity and poor biodistribution, poses significant challenges. Antibiotic resistance, aggravated by decades of uncontrolled cons…
ISEF · 2025
Physics and Astronomy
Simply expressed, antibubbles are the material opposite of soap bubbles. They consist internally of a virtually spherical volume of fluid that is separated from the surrounding fluid, typica…
JSHS · 2025
Per- and polyfluoroalkyl substances (PFAS) "forever chemicals" are common carcinogenic water pollutants, causing 382,000 global deaths annually. Over 600,000 military personnel are annually…
JSHS · 2025
After the use of fertilizers on gardens and lawns near bodies of water, it is common for chemicals (phosphates) to make their way into local waterways. It is also common for these chemicals…
ISEF · 2025
Environmental Engineering
Water pollution is a pressing global issue, exacerbated by inefficient wastewater treatment technologies that fail to remove emerging contaminants such as pharmaceuticals, antibiotics, and a…
JSHS · 2025
Nitric oxide sensing proteins (NosPs), have been studied as important signaling molecules in various organisms. Particularly in Pseudomonas aeruginosa, NosP plays a role in heme binding and…
JSHS · 2025
Antibiotic resistance is an increasingly prevalent issue as bacteria adapt to the overprescription of antibiotics, making the treatment of bacterial infections more difficult. To combat this…
ISEF · 2025
Engineering Technology: Statics & Dynamics
Drones are widely used in military and civilian applications, with VTOL (Vertical Takeoff and Landing) drones combining the vertical lift capability of helicopters with the horizontal cruisi…
JSHS · 2025
Drones are widely used in military and civilian applications, with VTOL (Vertical Takeoff and Landing) drones combining the vertical lift capability of multirotor helicopters with the horizo…
CYSF · 2025
This is a project on how FM radios work, also featuring AM radio research, electromagnetic waves electromagnetic spectrum modulation and types of modulation.
CYSF · 2025
The research and development of a virtual prototype for a hybrid prosthetic system that integrates myoelectric signals and brain-computer interface technology to enhance prosthetic limb func…
ISEF · 2025
Materials Science
Smart, thermo-responsive polymeric gel compositions were developed using alginate-p-NIPAM (poly-N-isopropylacrylamide) and biocompatible conductive segments. These waterborne formulations we…
ISEF · 2025
Earth and Environmental Sciences
Lake-effect precipitation, which significantly impacts regions downwind of the Great Lakes, poses unique forecasting challenges due to its dependence on localized processes and intricate int…
ISEF · 2025
Animal Sciences
Hot Springs National Park (HOSP) has had two inventories of its amphibians and reptiles in the last 20 years. Despite limited results, they remain the most conclusive research of HOSP’s herp…
ISEF · 2025
Behavioral and Social Sciences
This study introduces an innovative intervention using sleep wave simulation therapy to treat panic attacks. Panic disorder is a disabling condition characterized by recurrent, unexpected pa…
ISEF · 2025
Chemistry
Light is a promising alternative to traditional reagents for synthesis due to its reduced environmental toxicity, ease of control, and lowered cost. Moreover, photochemisty’s ability to crea…
ISEF · 2025
Computational Biology and Bioinformatics
Alzheimer’s disease (AD) affects 1 in 9 individuals aged 65+ in the U.S., with females twice as likely as males. As AD pathology begins decades before symptoms appear, early detection and in…
ISEF · 2025
Materials Science
Over 40% of chemotherapy patients suffer toxic side effects due to non-specific targeting, and most genetic therapies are prematurely degraded before they can reach target organs, limiting t…
ISEF · 2025
Systems Software
A fractal is a mathematical object with non-integer dimensions, characterized by self-similar patterns repeating at different scales. They help describe intricate natural phenomena, like the…