ISEF · 2014
Acne Treatments
Mathematics
I. Purpose: To determine the most effective acne medication in inhibiting bacterial growth II. Hypothesis: If I treat three bacteria cultures with three different acne medications, then mino…
Mathematics science fair projects from 2014
Browse real student projects, abstracts, and awards.
ISEF · 2014
A Comparative Study of the Antimicrobial & Synergistic Properties of Select Essential Oils and Clinical Disinfectants against Gram-positive & Gram-negative Clinical Isolates in vitro, Year III
Mathematics
Antimicrobial resistance is a worldwide epidemic that continues to spread out of control. With the emergence of superbugs such as Methicillin-resistant Staphylococcus aureus and Carbapenem-r…
ISEF · 2014
Adolescent Loss of Lis1 Results in Defective Hippocampal Morphology and Distinct Behavioral Deficits Resembling a Schizophrenic-Like Phenotype
Mathematics
In this project I established the Lis1 gene as a potential novel target for pharmaceutical treatment of schizophrenia. 80% of schizophrenics currently comply poorly with medication regimens,…
ISEF · 2014
AKT and pAKT Expression in Different Insulin Sensitive Tissues from C57BL/6J Mice
Mathematics
Purpose: Type II diabetes, along with obesity increasing in prominence in the United States and other countries, is characterized by hyperglycemia and insulin resistance to glucose uptake in…
ISEF · 2014
Alteration in Androgen Receptor Expression by the 3’ Untranslated Region
Mathematics
Background. Prostate cancer is the 2nd most common cancer in men and affects nearly 240,000 males annually in the United States with about 29,700 deaths each year. Androgen blocking is the m…
ISEF · 2014
Alzheimer's Disease Distribution in the Northwest in Relation to Microclimates, a Second Year Epidemiological Study
Mathematics
Since the discovery of Alzheimer’s disease by Dr. Alois Alzheimer in 1906, little attempt has been made to understand this disease spatially. In year 1 of this study, a correlation between A…
ISEF · 2014
Analyzing Novel Functions of Arb1 Ribosome Biogenesis Gene in Saccharomyces cerevisiae: A Suppression Analysis
Mathematics
Arb1 is an essential yeast protein associated with the protein production machinery in the cell known as the ribosome. This study will help to determine the ability to dynamically balance pr…
ISEF · 2014
Analyzing the Effect of Curcumin on a Cervical Cancer Line
Mathematics
This experiment focused on the effect Curcuma Longa, commonly known as Turmeric, on a HeLa cervical cancer cell line. It was conducted with the purpose to optimize an in-vitro model using a…
ISEF · 2014
A Natural Way to Improve Chemotherapy: Investigating the Effect of Biochanin A on the Efficacy of Thapsigargin in a C. elegans Cancer Model
Mathematics Third Award
Multidrug resistance is a major obstacle in the treatment of cancer. One of the major causes of resistance is P-glycoprotein, an ATP binding cassette transporter that binds and removes toxin…
ISEF · 2014
An Efficient Method to Extract Antimicrobial Saponins from Agave americana and their Application in Fruit Preservation
Mathematics
Saponins are foaming glycosides, consisting of a polycyclic aglycone that is either a choline steroid or triterpenoid attached to one or more sugar side chains. Saponins have received a numb…
ISEF · 2014
A New Pathway for Alzheimer’s Drugs: Modification of BACE1 to Decrease the Release of Beta Amyloid in the Brain
Mathematics
Alzheimer’s disease is the 5th leading cause of mortality in the elderly population. The disease progresses through the formation of plaques in neuronal synapses, leading to neuronal death.…
ISEF · 2014
An Exploratory Investigation of microRNA Regulation of ACSL4 in Androgen Deprivation Therapy Resistant Prostate Cancer
Mathematics
One prominent treatment for prostate cancer is androgen deprivation therapy, which slows tumor growth by targeting the androgen receptor signaling pathway. Unfortunately, most tumors progres…
ISEF · 2014
A Novel Approach Using Ultraviolet Radiation to Eliminate Bacteria Leading to Nosocomial Infections on Data Entry Peripherals in Hospitals
Mathematics
Nosocomial infections, along with hospital errors, are one of the leading causes of death in America, resulting in 99,000 deaths annually. The problem being addressed is the prevalence of ba…
ISEF · 2014
A Novel Device for the Detection of Chronic Transplant Rejection
Mathematics
Currently, organ transplantation is the best treatment available for patients experiencing end-stage heart and kidney failure. Unfortunately, the ten-year survival rate of a transplanted org…
ISEF · 2014
A Novel Egg Timer Test on the Horizon: Changing Womens' Lives
Mathematics
The egg timer test is a novel test that allows women to know how fast their biological clock is ticking. The test measures anti-Mullerian Hormone/Mullerian inhibiting substance (AMH/MIS), a…
ISEF · 2014
A Novel Hybrid Non-invasive Clinical-Signal Processing Technique as Biomarker of Atrial Fibrillation
Mathematics
Atrial fibrillation (AFib) is a type of arrhythmia, where atria contract fast/irregularly due to a dysfunctional cardiac electrical system. AFib starts paroxysmally, and advances to persiste…
ISEF · 2014
A Novel In-Clinic Patient- and Cancer- Tailored Targeted Drug Delivery System
Mathematics
Nanoparticle (NP) targeted drug delivery systems (TDDS) provide protection and enhanced uptake of therapeutics. Existing TDDS technology consists of pre-manufactured NPs with fixed targeting…
ISEF · 2014
A Novel Response to Antibiotic Resistance: Application of Microparticles and AC Currents
Mathematics
As antibiotic resistance becomes an increasing issue, the need for a non-antibiotic solution increases. Recent papers indicated that high frequency AC currents were safe and applicable in vi…
ISEF · 2014
A Novel Study on Behavioral and Reproductive Consequences of Embryonic Exposure to BPA and BPS in the C. elegans Model
Mathematics
Increasing reports about the toxic effects of bisphenol A (BPA), a neuroendocrine-disrupting chemical primarily found in polycarbonate plastic bottles, have led the plastics industry to repl…
ISEF · 2014
Antibiotic Resistance Dissemination Increased by High Frequency of Conjugating Bacteria in Escherichia coli Populations
Mathematics
According to the World Health Organization, the total societal cost of antibiotic resistance amounts to over $35 billion dollars per year in the United States alone when accounting for lost…
ISEF · 2014
Aqueous Extracts of Cinnamomum spp., Syzygium romaticum and Cinnamaldehyde and Their Effects on the Growth of MDA-MB-231
Mathematics
Throughout history, plant extracts have been used as treatments for a number of different illnesses. Past research suggests that clove oil and Eugenol, a chemical found both in cloves and ci…
ISEF · 2014
Are Sialic Acid Levels Altered in Human GM3 Synthase Deficiency?: Comparison to Ganglioside GM3 Levels in Amish Infantile-Onset Epilepsy Syndrome
Mathematics
Over 65 million people worldwide are affected by epilepsy, and there is no known cause for 60% of these cases. GM3 Synthase Deficiency is due to the loss of function of an enzyme at the head…
ISEF · 2014
Aspirin and Salicylic Acid in the Combination with Inhibition of PI3K Promote Cell Death in Malignant Melanoma
Mathematics
Aspirin (acetylsalicylic acid) and salicylic acid are anti-inflammatory drugs with several molecular targets in cells. They were also found to suppress the growth of prostate and colon cance…
ISEF · 2014
Assessing Antimicrobial Properties of Selected Local Homeopathic Plants
Mathematics
The purpose of this experiment was to determine if selected local trees (Sage brush (Artemisia tridentate), Balsam poplar (Populus balsamifera), and Trembling Aspen (Populus tremuloides)) co…
ISEF · 2014
a-synuclein rs356219 Polymorphisms in Patients with Gaucher Disease and Parkinson’s Disease
Mathematics
Purpose of the Experiment: Mutations in ?-glucocerebrosidase, the genetic defect in Gaucher disease (GD), are an important susceptibility factor for Parkinson disease (PD). A PD effector is…
ISEF · 2014
Atherosclerosis-Inducing Cytotoxin 7-Ketocholesterol Is Mitigated by Exposure to 70-Kilodalton Heat Shock Protein in THP-1 Human Monocyte Cells
Mathematics
The 70-kilodalton heat shock protein (HSP70) is a cytoprotective protein produced at an elevated concentration in individuals afflicted with atherosclerosis and has been linked to reduced ri…
ISEF · 2014
Athletic Kicks vs. Strain of the Patellar Tendon
Mathematics
Athletics play a important role in American society. Injuries in athletics are inevitable, however there are ways one can prevent these injuries from occuring. Approximately 15% of all sport…
ISEF · 2014
Automated ECG Feature Extraction with Mathematical Morphology
Mathematics
Electrical activities in the heart can be detected using metallic electrodes in an electrocardiography procedure that produces the recording known as electrocardiogram (ECG). Characteristic…
ISEF · 2014
A Wearable Ultrasonic Device for the Early Detection of Tumor Recurrence
Mathematics Fourth Award
Cancer recurrence affects a large percentage of patients who have finished initial treatment. Unfortunately, with current detection methods, the chance of tumor regrowth can be high. Therefo…
ISEF · 2014
Bacteriophage Lotion: A Way of Preventing the Spread of Bacterial Diseases
Mathematics
The aim of this project is to create a prototype of a bacteriophages concentrated cream, which can, in some way, prevent diseases caused by certain types of bacteria. Thus, it will be easier…