Browse real student projects, abstracts, and awards.
ISEF · 2025
Computational Biology and Bioinformatics
Autism Spectrum Disorder (ASD) is a heterogeneous neurological disorder affecting approximately 1 in 100 children today. The diagnosis and treatment of ASD are complex, partly due to its obs…
ISEF · 2025
Computational Biology and Bioinformatics
Myocardial infarction, the leading cause of death in America, can be prevented by detecting risk factors early. I investigated the relationship between urine albumin-creatinine ratio (uACR)…
ISEF · 2025
Computational Biology and Bioinformatics
Colorectal cancer is the second leading cause of cancer deaths worldwide, with 154,270 cases and 52,900 deaths estimated in 2025. Conventional screening methods, such as imaging scans and bl…
ISEF · 2025
Computational Biology and Bioinformatics
Convolutional neural networks (CNN) have demonstrated notable success in various image reconnaissance tasks, leading to their further application in medical diagnosis. In this study, an expa…
ISEF · 2025
Computational Biology and Bioinformatics
A solid tumor is an abnormal mass of uncontrolled cell growth, typically originating in the breast, lung, or prostate. Its physiological features make treatment by traditional methods diffic…
ISEF · 2025
Computational Biology and Bioinformatics
Globally, health issues such as antibiotic-resistant infections and cancer become increasingly severe; however, the extensive time and cost required for drug development impose a significant…
ISEF · 2025
Computational Biology and Bioinformatics
Asthma and chronic obstructive pulmonary disease (COPD) are complex respiratory disorders with variable disease progression and heterogeneous treatment responses. While biologic therapies su…
ISEF · 2025
Computational Biology and Bioinformatics
This research expands existing Olfactory Receptor (OR) studies, exploring their potential in cancer drug therapy and establishing a novel pipeline applicable to similar G protein-coupled rec…
ISEF · 2025
Computational Biology and Bioinformatics
Richter Syndrome (RS) is a sudden complication that can occur in 2-10% of Chronic Lymphocytic Leukemia (CLL) patients where a second, much more dangerous and aggressive lymphoma can spring u…
ISEF · 2025
Computational Biology and Bioinformatics
Autism Spectrum Disorder (ASD), a neurodevelopmental disorder marked by heterogeneity, necessitates innovative diagnostic approaches. This study pioneers a multimodal deep ensemble network,…
ISEF · 2025
Computational Biology and Bioinformatics
The purpose of this study was to develop an artificial intelligence electrocardiogram (AI-ECG) model to predict dementia in older adults. It has been previously reported that by using derive…
ISEF · 2025
Computational Biology and Bioinformatics
One major challenge with cancer treatment is the widespread molecular differences that patient tumors can have, meaning only specific chemotherapies may work well. Machine learning models pr…
ISEF · 2025
Computational Biology and Bioinformatics
Alzheimer’s disease affects over 55 million people worldwide, making early prediction crucial for timely interventions to slow disease progression and improve quality of life. Single Nucleot…
ISEF · 2025
Computational Biology and Bioinformatics
Drug discovery is intricate and costly. Current methods in de novo drug design rely on undiversified and scarce datasets due to the impossibility of recording all intermolecular interactions…
ISEF · 2025
Computational Biology and Bioinformatics
Tau protein aggregation is a hallmark of Alzheimer's disease (AD), disrupting neuronal function and impairing synaptic signaling. The clinical efficacy of tau aggregation inhibitors like TRx…
ISEF · 2025
Computational Biology and Bioinformatics
T-cell malignancies contribute significantly to the high mortality rates of lung and colon cancers, two of the deadliest globally. Current CAR T-cell therapies, while promising, suffer from…
ISEF · 2025
Computational Biology and Bioinformatics
Sepsis—a global health priority declared by the World Health Organization—is a life-threatening immune response to infection and the cause of 20% of all deaths. Early recognition is crucial,…
ISEF · 2025
Computational Biology and Bioinformatics
Colorectal cancer (CRC) ranks as the second leading cause of cancer-related deaths worldwide. Although CRC incidence rates have traditionally been the highest in developed nations, they are…
ISEF · 2025
Computational Biology and Bioinformatics
Attention-Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder characterized by pervasive patterns of inattention, hyperactivity, and impulsivity that are inappropriate for…
ISEF · 2025
Computational Biology and Bioinformatics
5-Fluorouracil (5-FU), a common chemotherapy for solid tumors, is metabolized primarily by dihydropyrimidine dehydrogenase (DPD), encoded by the DPYD gene. With > 200 known variants, individ…
ISEF · 2025
Computational Biology and Bioinformatics
Biologists often take sequential 2D images at different heights to study biological structures. Last year, one of us wrote software that creates a 3D rendering from these images. This year,…
ISEF · 2025
Computational Biology and Bioinformatics
Nervous system disorders, including Alzheimer's and Parkinson's diseases, affected 43% of the global population in 2021 and are rapidly escalating. Projections indicate that by the year 2050…
ISEF · 2025
Computational Biology and Bioinformatics
Obesity-driven inflammation is primarily caused by pro-inflammatory immune cell infiltration, which leads to an increased secretion of pro-inflammatory cytokines like TNF and IL-6. This driv…
ISEF · 2025
Computational Biology and Bioinformatics
Competitive target-mediated drug disposition (competitive TMDD) has been used to describe the behavior of two different types of ligands competing for a common receptor. Due to the complexit…
ISEF · 2025
Computational Biology and Bioinformatics
This study aimed to identify potential inhibitors of meso-diaminopimelate decarboxylase (LYASE), a bacterial enzyme crucial for lysine biosynthesis, using molecular docking simulations. The…
ISEF · 2025
Computational Biology and Bioinformatics
Every year, approximately 90,000 people in the United States are diagnosed with lymphoma, a cancer impacting white blood cells called lymphocytes. The CD30 receptor, overexpressed in Hodgkin…
ISEF · 2025
Computational Biology and Bioinformatics
Cannabinoid receptor subtype 2 (CB2), a G protein-coupled receptor within the endocannabinoid system (ECS), has shown promise as a therapeutic target in cancer and inflammatory diseases due…
ISEF · 2025
Computational Biology and Bioinformatics
This study explores the effectiveness of Convolutional Bidirectional Long Short-Term Memory (Conv-Bi-LSTM) in detecting neonatal seizure activity using Electroencephalogram (EEG) data, based…
ISEF · 2025
Computational Biology and Bioinformatics
Mental imagery is a sophisticated brain function that enables high-level inference and creation. The ability for mental imagery varies among individuals along various dimensions, such as viv…
ISEF · 2025
Computational Biology and Bioinformatics
Continuous glucose monitoring (CGM) systems are crucial in diabetes care, but focus only on monitoring blood glucose levels (BGL), neglecting diet, exercise, and medication and lacking predi…