Browse real student projects, abstracts, and awards.
ISEF · 2021
Computational Biology and Bioinformatics Fourth Award
Diversity generating retroelements (DGRs) are genetic elements that promote hyper mutations in specific regions of the genome. The targeted mutations of DGRs allow positive traits to manifes…
ISEF · 2021
Computational Biology and Bioinformatics
This study aims to develop a network for prominent chronic illnesses and neurodegenerative diseases, factoring in preexisting conditions, lifestyle decisions, and an individual’s environment…
ISEF · 2021
Computational Biology and Bioinformatics Third Award
Amyloid-beta is an intrinsically disordered protein involved in neurodegenerative disorders. Previously, amyloid-beta was considered “undruggable” due to its shape-shifting properties. Howev…
ISEF · 2021
Computational Biology and Bioinformatics Fourth Award
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder characterized by death of upper and lower motor neurons and progressive paralysis of the extremities. ALS is a compl…
ISEF · 2021
Computational Biology and Bioinformatics Second Award
Our survival depends on the brain's adaptation of information processing to changing cognitive demands; this ability stems from the interactions of specialized brain networks. At rest, netwo…
ISEF · 2021
Computational Biology and Bioinformatics
??-helical coiled coils are protein substructures that play important roles in a wide range of biological events. Some types of coiled coils are used by various viruses (eg SARS-CoV2) to ent…
ISEF · 2021
Computational Biology and Bioinformatics
The microscopic structure of bone contributes to its resistance to crack propagation and high damage tolerance under mechanical loading. In everyday life, bone accumulates tiny fractures, ca…
ISEF · 2021
Computational Biology and Bioinformatics
Neurodegenerative diseases are one of the highest causes of death within the world. The WHO reported in 2016 that Alzheimer’s Disease and dementia were the 5th highest cause of death interna…
ISEF · 2021
Computational Biology and Bioinformatics
This research studied the gene expression profiles of small nuclear RNA (snRNA) and small nucleolar RNA (snoRNA) in Preeclampsia (PE), compared to term and idiopathic (iPTB) patients. The pu…
ISEF · 2021
Computational Biology and Bioinformatics Third Award
The cocktail party problem renders conversation difficult for hard-of-hearing individuals in multi-speaker environments. Current hearing aids cannot amplify the primary speaker's voice alone…
ISEF · 2021
Computational Biology and Bioinformatics
Recent rise in COVID-19 cases has highlighted the need for effective and targeted measures to reduce the spread of the virus. Consequently, app-based tracing strategies have been proposed as…
ISEF · 2021
Computational Biology and Bioinformatics
Current processes of drug discovery are too long, expensive, and ineffective. Companies undergo years of research and development without the certainty of obtaining conclusive results. Drug…
ISEF · 2021
Computational Biology and Bioinformatics Third Award
Scoliosis is a condition of abnormal spinal curvature with approximately 60,000 U.S. pediatric patients undergoing surgery or being placed into braces each year. Skeletal maturity assessment…
ISEF · 2021
Computational Biology and Bioinformatics
Cancer threatens millions of individuals every year and remains a central issue in the scientific community. It’s important to search for new alternative treatments, and anticancer peptides…
ISEF · 2021
Computational Biology and Bioinformatics
Cancer is a leading cause of human death worldwide, yet quick and accurate identification of the primary cancer site is still lacking. Owing to its ability to differentiate similar tumors an…
ISEF · 2021
Computational Biology and Bioinformatics Fourth Award
Current techniques of target identification in drug development are costly, lengthy, and function with high degrees of uncertainty that a drug can succeed in modulating a target. To address…
ISEF · 2021
Computational Biology and Bioinformatics
Seizures, sudden bursts of electrical activity in cortical neurons, occur frequently in neonates (1-28 days old) and are a common emergency in the NICU. Timely and proper treatment is crucia…
ISEF · 2021
Computational Biology and Bioinformatics
Wolbachia, a species of endosymbiotic intracellular bacteria found in a diverse set of species, is most notable for its role in vector control strategies to reduce the spread of diseases tha…
ISEF · 2021
Computational Biology and Bioinformatics
To limit the spread of COVID-19, government policies are necessary. Current research focuses primarily on documenting proposed policies rather than assessing the efficacy of said proposals.…
ISEF · 2021
Computational Biology and Bioinformatics
In this work, I studied cas9 protein, one of the proteins of the CRISPR-Cas bacterial defense system. It was chosen because a genome editing system based on it is currently under development…
ISEF · 2021
Computational Biology and Bioinformatics Fourth Award
Alzheimer’s Disease is a progressive neurodegenerative disease that results in memory loss and a general cognitive decline, afflicting approximately 45 million people worldwide with the rate…
ISEF · 2021
Computational Biology and Bioinformatics
Melanoma is one of the most fatal forms of skin cancer and is often very difficult to differentiate from other benign skin lesions. However, if detected at its early stages, it can almost al…
ISEF · 2021
Computational Biology and Bioinformatics Fourth Award
In recent decades, there's been an alarming increase in bacterial evasion of antibiotic treatments, necessitating an improved understanding of resistance, tolerance, and persistence. Resista…
ISEF · 2021
Computational Biology and Bioinformatics
Early detection and treatment of colorectal cancer is vital to prevent metastasis, but past models lack a cohesive pipeline from diagnosis to treatment to determine biomarkers and suggest tr…
ISEF · 2021
Computational Biology and Bioinformatics
If adjacent genes in the same direction (Tail-to-Head, T2H) are located very close to each other (at a distance of several hundred base pairs) or partially overlapping, chimeric transcripts…
ISEF · 2021
Computational Biology and Bioinformatics
As of April 9th, 2021, there have been over 31 million cases of COVID-19 in the United States alone. Simultaneously, an estimated 15% of U.S. adults suffer from Chronic Kidney Disease (CKD).…
ISEF · 2021
Computational Biology and Bioinformatics Fourth Award
My project aims to identify a therapy to treat COVID-19 infections using gene expression and a computer-assisted approach. My computer program, AMiF (Augmented miRNA Filtration Model) works…
ISEF · 2021
Computational Biology and Bioinformatics
With major outbreaks in over 150 countries, the COVID-19 pandemic has had a devastating effect on public health, daily life, and the global economy. Absent a vaccine or therapeutic treatment…
ISEF · 2021
Computational Biology and Bioinformatics
While pancreatic cancer is a deadly disease that is difficult to diagnose at an early stage, early diagnosis yields a much higher survival rate, making it key for treatment. With an increase…
ISEF · 2021
Computational Biology and Bioinformatics
Influenza virus is a single-stranded negative RNA virus, divided into three types, A, B, and C (Shao, Li, Goraya, Wang, & Chen, 2017). This research focused on influenza type A, which mainly…