Browse real student projects, abstracts, and awards.
ISEF · 2014
Computational Biology and Bioinformatics
The purpose of this experiment was to characterize a newly discovered ultrastable silver nanoparticle. Silver is known to be susceptible to oxidation while metals such as gold and platinum a…
ISEF · 2014
Computational Biology and Bioinformatics Fourth Award
Upon encountering antigens in the germinal centers of peripheral lymphoid organs such as the spleen or lymph nodes, mature B-lymphocytes undergo class switch recombination (CSR). CSR alters…
ISEF · 2014
Computational Biology and Bioinformatics
Glaucoma is a neurodegenerative disease that causes ganglion cell death in the retina, leading to vision loss. To study the effects of glaucoma, the DBA/2J mouse has proven to be a precise m…
ISEF · 2014
Computational Biology and Bioinformatics Second Award
My research develops a tool to enable the first ever genome-wide analysis of genetic variants, specifically single nucleotide polymorphisms (SNPs), in transcription factor binding sites. The…
ISEF · 2014
Computational Biology and Bioinformatics
Alzheimer’s disease (AD) is a neurodegenerative disorder resulting from the buildup of neuritic plaques and neurofibrillary tangles. Those with AD exhibit worsening memory and language funct…
ISEF · 2014
Computational Biology and Bioinformatics
In this study, I conducted laboratory tests that produced induced pluripotent stem cells (iPS) that could be used as an alternative to the use of embryonic stem cells. Using human buccal che…
ISEF · 2014
Computational Biology and Bioinformatics
Lymphopenia, a condition in which the number of lymphocytes falls below normal levels, makes patients more susceptible to infection and disease, and can be caused by genetic predisposition o…
ISEF · 2014
Computational Biology and Bioinformatics First Award
As the leading cause of cancer-related deaths in women worldwide, breast cancer metastasis remains refractory to current therapy. Residing in the Polycomb protein group and altering the chro…
ISEF · 2014
Computational Biology and Bioinformatics
Analyzing how drugs affect the cell cycle requires cell cycle analysis. An approach using flow cytometry is limiting as the only parameter that can be collected is intensity. In order to obt…
ISEF · 2014
Computational Biology and Bioinformatics
New transition metal complexes of Co(II), Ni(II), Cu(II) and Zn(II) with the Schiff bases derived by condensation of 3-formyl-2-hydroxy quinoline with Guanine(GUOH) and 3-formyl-2-mercapto q…
ISEF · 2014
Computational Biology and Bioinformatics Fourth Award
Fruits and vegetables provide us nutrition including vitamins and minerals to stay healthy – both mentally and physically. In pursuit of a pest-free produce, farmers use pesticides, far abov…
ISEF · 2014
Computational Biology and Bioinformatics
Chemotherapy is currently the number one remedy for cancer. The side effects are significant and lead to various problems such as hair loss. Recently research has shown that compounds such a…
ISEF · 2014
Computational Biology and Bioinformatics
Parkinson’s disease (PD) is caused by the unknown death of dopamine-generating cells in the substantia nigra. The pathology of PD is determined by neurodegeneration of dopaminergic neuron an…
ISEF · 2014
Computational Biology and Bioinformatics
This study aims to characterize the role of p53, a tumor suppressor protein, in tumor-initiating cells. An emerging theory in cancer research is that tumor progenitor cells can give rise to…
ISEF · 2014
Computational Biology and Bioinformatics
Damage to mitochondrial DNA is correlated with a wide array of diseases, such as diabetes, obesity, heart disease, and aging. MtDNA can be depleted experimentally by treating cells with ethi…
ISEF · 2014
Computational Biology and Bioinformatics Third Award
Human Immunodeficiency Virus (HIV) causes immunosuppression resulting in acquired immunodeficiency syndrome (AIDS). A closely related virus, Simian Immunodeficiency Virus (SIV), is commonly…
ISEF · 2014
Computational Biology and Bioinformatics First Award
Induced pluripotent stem cells (iPSCs) could revolutionize patient-specific regenerative medicine, but their premature aging symptoms, currently misunderstood, limit their clinical applicabi…
ISEF · 2014
Computational Biology and Bioinformatics
To separate and identify metallic ions, precipitation and filtration should be repeated. Furthermore, many kinds of reagents should be used and operations are complicated. A new method for s…
ISEF · 2014
Computational Biology and Bioinformatics
A byproduct of many cellular metabolic reactions is reactive oxygen species (ROS). An increase in ROS levels or a decrease in the cellular antioxidant capacity causes oxidative stress and is…
ISEF · 2014
Computational Biology and Bioinformatics Third Award
The zebrafish (Danio rerio) lateral line consists of a system of sensory organs that are optimal for in vivo studies of hair cell death and protection. Zebrafish hair cells are both structur…
ISEF · 2014
Computational Biology and Bioinformatics Third Award
The purpose of this study was to determine the potential changes in the expression of microRNAs -155, -146a, -29a, and -21 in macrophages cultured under diabetic conditions. MicroRNA (miRNA)…
ISEF · 2014
Computational Biology and Bioinformatics
Regenerative medicine is seen as the future for cardiovascular health. Adult human cardiomyocytes have very little proliferative capacity. However, neonatal mice have shown very high levels…
ISEF · 2014
Computational Biology and Bioinformatics
Macrophages are vital cells of the immune system with roles in protecting against infection. Macrophages internalize chemicals or pathogens through phagocytosis or pinocytosis. Macropinocyto…
ISEF · 2014
Computational Biology and Bioinformatics
Resveratrol is known as a powerful antioxidant present in many foods, especially in grapes and red wine. My study investigated the mutagenic effects of three increasing concentrations of Res…
ISEF · 2014
Computational Biology and Bioinformatics
Endothelial Cells form blood vessels, so knowing of how Macrophages and Endothelial Cells interact can be beneficial in finding therapies for diseases such as Cardiovascular disease, atheros…
ISEF · 2014
Computational Biology and Bioinformatics Third Award
The main objective of my project is to develop the simple, cost-effective, reusable electrochemical sensor (electronic tongue) that can simultaneously and accurately detect cadmium (Cd), mer…
ISEF · 2014
Computational Biology and Bioinformatics
NG2-glia are a class of glial cells in the brain that play a critical role in synaptic regulation and myelination through their structural support of axons and oligodendrocytes. In the insta…
ISEF · 2014
Computational Biology and Bioinformatics
Visualizing differentiation of cancer cells is a crucial method of measuring cancer progression. A novel fluorescent protein reporter construct was designed with the purpose of recombining t…
ISEF · 2014
Computational Biology and Bioinformatics
During the course of the past two years, the effects of antioxidants on cell viability and bacterial growth have been tested. The addition of anthocyanins to cancer cell cultures significant…
ISEF · 2014
Computational Biology and Bioinformatics
Coal is one of the world’s largest assets in terms of energy, in 2012 coal provided 41% of the entire worlds electricity. In order to provide so much energy large reserves of coal were burne…