Browse real student projects, abstracts, and awards.
ISEF · 2025
Computational Biology and Bioinformatics
The m6a methylation of the TAR region promotes neuroinflammation in HIV-1 neurocognitive disorders. This is facilitated by the RBM15 protein recognizing and binding U-rich bulges to act as a…
ISEF · 2025
Computational Biology and Bioinformatics
MicroRNAs (miRNAs) with highly dysregulated expression levels, have so far constituted the focus of disease-specific biomarkers research. However, the complex regulating mechanisms between m…
ISEF · 2025
Computational Biology and Bioinformatics
Lung cancer remains the leading cause of cancer-related mortality, primarily due to its high metastatic potential and the difficulty of early detection. Current clinical approaches rely on a…
ISEF · 2025
Computational Biology and Bioinformatics
Molecular dynamics (MD) simulations model how proteins change conformation during key processes like folding and substrate binding. However, simulating every atom, as is done in all-atom sim…
ISEF · 2025
Computational Biology and Bioinformatics
Traditional Darwinian models of evolution treat adaptive selection as the primary evolutionary factor for most traits. Although this approach is predictive in many cases, it struggles to exp…
ISEF · 2025
Computational Biology and Bioinformatics
Over 70 million in the world suffer from stuttering, a speech impairment characterized by involuntary disruptions during normal speech. This can create communication barriers and limiting ac…
ISEF · 2025
Computational Biology and Bioinformatics
Diabetes significantly worsens breast cancer (BC) progression by enhancing pathological angiogenesis through metabolic stress, increasing mortality rates by up to 40%. As molecular factors a…
ISEF · 2025
Computational Biology and Bioinformatics
Cancer is a complex disease affecting millions globally, encompassing various types such as breast, pancreatic and brain cancers, each requiring tailored treatment. A crucial enzyme in many…
ISEF · 2025
Computational Biology and Bioinformatics
Pancreatic cancer has a low five-year survival rate (<11%), with only 9.7% detected early due to its subtle presentation in imaging. Pancreatic carcinoma typically appears as a poorly enhanc…
ISEF · 2025
Computational Biology and Bioinformatics
While it is a relatively well-researched cancer therapy study, the difference in efficacy between lycopene isomers has not been explored. This carotenoid is mainly utilized for its antioxida…
ISEF · 2025
Computational Biology and Bioinformatics
Systemic Lupus Erythematosus (SLE) is a complex chronic autoimmune disease characterized by widespread inflammation and tissue damage. Its multifactorial etiology, involving a variety of env…
ISEF · 2025
Computational Biology and Bioinformatics
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron degeneration. Although biomarkers have been identified, they lack specificity. Combined with…
ISEF · 2025
Computational Biology and Bioinformatics
Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder that can lead to chronic obstructive pulmonary disease (COPD), a progressive lung condition that causes breathing difficulty. AATD…
ISEF · 2025
Computational Biology and Bioinformatics
Drug-drug synergy is crucial for developing effective combination therapies, and gene function relationships play an important role in identifying these synergies. However, due to the comple…
ISEF · 2025
Computational Biology and Bioinformatics
Globally, countless organisms suffer from infections, diseases, and environmental threats. Custom proteins are at the heart of solutions to these challenges. Custom proteins are life-saving…
ISEF · 2025
Computational Biology and Bioinformatics
Carcinogenicity assessment is vital in public health and regulatory compliance in multiple industries. In vivo bioassays are costly and time-consuming, while in vitro assays can be simplisti…
ISEF · 2025
Computational Biology and Bioinformatics
Protocadherins (pcdhs) are responsible for the formation of cell to cell adhesion proteins, which makes them crucial to neural development and function. Clustered protocadherins are a type o…
ISEF · 2025
Computational Biology and Bioinformatics
Immunohistochemistry is a popular method for diagnosing diseases like cancer. To make a diagnosis, pathologists manually analyze every cell in a tissue sample, which is time-consuming and pr…
ISEF · 2025
Computational Biology and Bioinformatics
The growing prevalence of neurodegenerative diseases underscores the importance of improved diagnostic accuracy. Many proposed Clinical Decision Support Systems (CDSS) have low interpretabil…
ISEF · 2024
Computational Biology and Bioinformatics Fourth Award
The ability to visualize cell behavior within the 3-dimensional space of a tissue is invaluable for understanding cell function. Although open-source and professional software exist to analy…
ISEF · 2024
Computational Biology and Bioinformatics
The global bird population decline due to climate change, pollution, and habitat destruction is a critical challenge. Addressing this global issue is vital for biodiversity preservation and…
ISEF · 2024
Computational Biology and Bioinformatics
According to the WHO, nearly 50 million people suffer from epilepsy, one of the most common neurological diseases. Deaths caused by epilepsy have doubled over the past decade. Epilepsy is ch…
ISEF · 2024
Computational Biology and Bioinformatics
Vision is a critical mode of perception that guides behavioral responses in many organisms. It is loosely grouped into two stages, sensing by photoreceptors and processing, further divided i…
ISEF · 2024
Computational Biology and Bioinformatics
Alzheimer's disease (AD) is a neurodegenerative condition primarily occurring in later life, severely impacting cognitive abilities until it ultimately leads to death. Due to demographic shi…
ISEF · 2024
Computational Biology and Bioinformatics
Missense variants have the potential to result in disease development attributable to protein variants. Current genetic tests evaluate the potential for disease development by querying vario…
ISEF · 2024
Computational Biology and Bioinformatics
Disease pathogenesis is closely associated with genetically influenced metabolites. The identification of individualized metabolite-disease associations is crucial in advancing personalized…
ISEF · 2024
Computational Biology and Bioinformatics
Sequence alignment tools have traditionally been used to study the evolution of genome sequences by aligning sequences of varying lengths. However, these tools are memory-intensive, time-con…
ISEF · 2024
Computational Biology and Bioinformatics Third Award
The estrous cycle regulates reproductive events and hormone changes in female mammals and is akin to the menstrual cycle in humans. Monitoring the cycle is necessary as it is a biomarker for…
ISEF · 2024
Computational Biology and Bioinformatics
Aging involves a gradual decline in physiological functions, heightening morbidity and mortality risks through diminished organ function, muscle mass, bone density, and a compromised immune…
ISEF · 2024
Computational Biology and Bioinformatics
Disease pathways are in great need of study. The understanding of disease pathways can result in the development of more individualized methods for diagnosis and treatment of various disease…