38,465 real projects from ISEF, the Canada-Wide Science Fair, JSHS, AJAS, the Calgary Youth Science Fair and the California Science & Engineering Fair — searchable by meaning, and filterable by fair, year, category and award.
ISEF · 2025
Computational Biology and Bioinformatics
Accurate classification of brain tumors is essential for effective patient treatment. In recent years, artificial intelligence has shown significant promise in improving medical diagnostics.…
ISEF · 2025
Computational Biology and Bioinformatics Third Award
Alzheimer’s disease (AD) affects 1 in 9 individuals aged 65+ in the U.S., with females twice as likely as males. As AD pathology begins decades before symptoms appear, early detection and in…
ISEF · 2025
Computational Biology and Bioinformatics
This project investigates the genetic mechanisms underlying Alzheimer's Disease (AD) and Limbic-Predominant Age-Related TDP-43 Encephalopathy (LATE) and their co-occurrence by analyzing diff…
AJAS · 2025
Computational Biology and Bioinformatics (inferred)
Alzheimer's disease (AD), a progressive neurodegenerative disorder affecting over 50 million globally, has seen limited success with FDA-approved treatments targeting amyloid beta (Aβ) aggre…
ISEF · 2025
Computational Biology and Bioinformatics
Perchlorates are environmental pollutants that damage the human thyroid gland, stemming from military operations, rocket propellants, and fertilizer runoff. They also compose 0.5-1% of Marti…
ISEF · 2025
Computational Biology and Bioinformatics Fourth Award
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline severe enough to interfere with daily activities. Current diagnostic methods, such as…
ISEF · 2025
Computational Biology and Bioinformatics
As the annual number of amputations continues to rise, limb loss continues to impede the daily lives of over 50 million people worldwide. Though several prosthetic options are available, mos…
ISEF · 2025
Computational Biology and Bioinformatics Fourth Award
Climate change poses a significant threat to global ecosystems. Current mitigation strategies are inefficient and costly. Biological solutions, specifically algae, offer a promising alternat…
ISEF · 2025
Computational Biology and Bioinformatics
The m6a methylation of the TAR region promotes neuroinflammation in HIV-1 neurocognitive disorders. This is facilitated by the RBM15 protein recognizing and binding U-rich bulges to act as a…
ISEF · 2025
Computational Biology and Bioinformatics Fourth Award
MicroRNAs (miRNAs) with highly dysregulated expression levels, have so far constituted the focus of disease-specific biomarkers research. However, the complex regulating mechanisms between m…
ISEF · 2025
Computational Biology and Bioinformatics Third Award
Lung cancer remains the leading cause of cancer-related mortality, primarily due to its high metastatic potential and the difficulty of early detection. Current clinical approaches rely on a…
AJAS · 2025
Computational Biology and Bioinformatics (inferred)
Breast cancer affects 2.3 million women annually with the five-year survival rate for triple-negative-breast-cancer (TNBC) around 12%. Current immunotherapy treatments are effective only in…
ISEF · 2025
Computational Biology and Bioinformatics Second Award
Molecular dynamics (MD) simulations model how proteins change conformation during key processes like folding and substrate binding. However, simulating every atom, as is done in all-atom sim…
ISEF · 2025
Computational Biology and Bioinformatics
Traditional Darwinian models of evolution treat adaptive selection as the primary evolutionary factor for most traits. Although this approach is predictive in many cases, it struggles to exp…
ISEF · 2025
Computational Biology and Bioinformatics First Award
Over 70 million in the world suffer from stuttering, a speech impairment characterized by involuntary disruptions during normal speech. This can create communication barriers and limiting ac…
ISEF · 2025
Computational Biology and Bioinformatics
Diabetes significantly worsens breast cancer (BC) progression by enhancing pathological angiogenesis through metabolic stress, increasing mortality rates by up to 40%. As molecular factors a…
ISEF · 2025
Computational Biology and Bioinformatics
Cancer is a complex disease affecting millions globally, encompassing various types such as breast, pancreatic and brain cancers, each requiring tailored treatment. A crucial enzyme in many…
ISEF · 2025
Computational Biology and Bioinformatics Third Award
Pancreatic cancer has a low five-year survival rate (<11%), with only 9.7% detected early due to its subtle presentation in imaging. Pancreatic carcinoma typically appears as a poorly enhanc…
ISEF · 2025
Computational Biology and Bioinformatics
While it is a relatively well-researched cancer therapy study, the difference in efficacy between lycopene isomers has not been explored. This carotenoid is mainly utilized for its antioxida…
ISEF · 2025
Computational Biology and Bioinformatics
Systemic Lupus Erythematosus (SLE) is a complex chronic autoimmune disease characterized by widespread inflammation and tissue damage. Its multifactorial etiology, involving a variety of env…
ISEF · 2025
Computational Biology and Bioinformatics First Award
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron degeneration. Although biomarkers have been identified, they lack specificity. Combined with…
ISEF · 2025
Computational Biology and Bioinformatics
Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder that can lead to chronic obstructive pulmonary disease (COPD), a progressive lung condition that causes breathing difficulty. AATD…
ISEF · 2025
Computational Biology and Bioinformatics Fourth Award
Drug-drug synergy is crucial for developing effective combination therapies, and gene function relationships play an important role in identifying these synergies. However, due to the comple…
ISEF · 2025
Computational Biology and Bioinformatics
Globally, countless organisms suffer from infections, diseases, and environmental threats. Custom proteins are at the heart of solutions to these challenges. Custom proteins are life-saving…
ISEF · 2025
Computational Biology and Bioinformatics
Carcinogenicity assessment is vital in public health and regulatory compliance in multiple industries. In vivo bioassays are costly and time-consuming, while in vitro assays can be simplisti…
ISEF · 2025
Computational Biology and Bioinformatics
Protocadherins (pcdhs) are responsible for the formation of cell to cell adhesion proteins, which makes them crucial to neural development and function. Clustered protocadherins are a type o…
ISEF · 2025
Computational Biology and Bioinformatics
Immunohistochemistry is a popular method for diagnosing diseases like cancer. To make a diagnosis, pathologists manually analyze every cell in a tissue sample, which is time-consuming and pr…
ISEF · 2025
Computational Biology and Bioinformatics Second Award
The growing prevalence of neurodegenerative diseases underscores the importance of improved diagnostic accuracy. Many proposed Clinical Decision Support Systems (CDSS) have low interpretabil…
ISEF · 2024
Computational Biology and Bioinformatics Fourth Award
The ability to visualize cell behavior within the 3-dimensional space of a tissue is invaluable for understanding cell function. Although open-source and professional software exist to analy…
ISEF · 2024
Computational Biology and Bioinformatics
The global bird population decline due to climate change, pollution, and habitat destruction is a critical challenge. Addressing this global issue is vital for biodiversity preservation and…