Browse real student projects, abstracts, and awards.
ISEF · 2025
Computational Biology and Bioinformatics
Mental imagery is a sophisticated brain function that enables high-level inference and creation. The ability for mental imagery varies among individuals along various dimensions, such as viv…
ISEF · 2025
Computational Biology and Bioinformatics
Continuous glucose monitoring (CGM) systems are crucial in diabetes care, but focus only on monitoring blood glucose levels (BGL), neglecting diet, exercise, and medication and lacking predi…
ISEF · 2025
Computational Biology and Bioinformatics
Purpose: Alcohol-related liver disease (ALD) is a leading cause of liver failure worldwide. This study aims to identify differentially expressed genes and affected biological pathways in lat…
ISEF · 2025
Computational Biology and Bioinformatics
The emergence of TEM-171 Beta-lactamase represents a significant threat to modern antimicrobial therapy due to its ability to hydrolyze an extended spectrum of Beta-lactam antibiotics. While…
ISEF · 2025
Computational Biology and Bioinformatics
With 50 million people suffering globally, Alzheimer’s Disease stands as one of the most devastating neurodegenerative disorders, yet no cure or preventative therapy exists (Yang et al., 202…
ISEF · 2025
Computational Biology and Bioinformatics
CRISPR Cas9 is a gene-editing tool that holds immense importance for precision medicine, yet off-target effects remain as a major challenge. This project aims to design ligand-functionalized…
ISEF · 2025
Computational Biology and Bioinformatics
Traditional drug discovery exceeds 10 years and $2 billion per drug. Conventional Quantitative Structure-Activity Relationship (QSAR) models only identify single-target inhibitors and lack b…
ISEF · 2025
Computational Biology and Bioinformatics
Dysregulated dopamine in the mesolimbic system is linked to disorders like schizophrenia, depression, and addiction. Low phasic dopamine release correlates with reduced drug reward sensitivi…
ISEF · 2025
Computational Biology and Bioinformatics
Salmonella is a common pathogen, infecting more than a hundred million people yearly. About 8% of these cases worldwide result in life-threatening conditions around 4-7 days after exposure.…
ISEF · 2025
Computational Biology and Bioinformatics
Non-pharmaceutical interventions to COVID-19 included mask mandates, social distancing mandates (banning large gatherings, advising individuals not to socialize outside their households), sc…
ISEF · 2025
Computational Biology and Bioinformatics
Diabetes mellitus is one of the various types of major metabolic diseases that affect over 800 million people worldwide, according to the World Health Organization. The number of people livi…
ISEF · 2025
Computational Biology and Bioinformatics
This study investigated the inhibitory potential of 41 polyprenylated benzophenones (PPBs) from Garcinia species against TEM52 ß-lactamase, aiming to identify a potential non-competitive inh…
ISEF · 2025
Computational Biology and Bioinformatics
Alzheimer’s Disease (AD), a neurodegenerative disorder linked to pathologies characterized with neural cognitive decline, has recently been connected to iron dysregulation and ferroptosis in…
ISEF · 2025
Computational Biology and Bioinformatics
MicroRNAs (miRNAs) are non-coding RNAs that bind to the coding sequences of target messenger RNAs (mRNAs), where they regulate gene expression. Mutations of miRNA binding sites within risk g…
ISEF · 2025
Computational Biology and Bioinformatics
Alzheimer’s disease (AD) is the seventh leading cause of death in the U.S. and remains incurable. Most existing therapeutics target beta-amyloid plaques, but plaque removal has shown no evid…
ISEF · 2025
Computational Biology and Bioinformatics
Pathogenic fungi of the Candida genus, including C. albicans, pose an increasing threat to global health. Almost all Candida species belong to the CTG clade, which deviates from the common g…
ISEF · 2025
Computational Biology and Bioinformatics
Neurodegenerative disease therapeutic development faces hurdles from multi-omic complexity and the poor interpretability of standard ML models (e.g., MLPs), limiting target discovery. We dev…
ISEF · 2025
Computational Biology and Bioinformatics
Alzheimer's disease (AD) is a complex, progressive neurodegenerative disorder characterized by extracellular Aß plaques, neurofibrillary tau tangles, and neuronal degeneration, involving mul…
ISEF · 2025
Computational Biology and Bioinformatics
Lung cancer is the most commonly diagnosed cancer worldwide and the leading cause of cancer-related deaths. It is difficult to diagnose accurately, especially at an early stage. No tradition…
ISEF · 2025
Computational Biology and Bioinformatics
Inflammatory diseases affect billions of patients worldwide. Receptor for Advanced Glycation End products (RAGE) has been identified as a promising target for many inflammatory diseases, inc…
ISEF · 2025
Computational Biology and Bioinformatics
Mangroves play a crucial role in coastal protection, biodiversity support, carbon sequestration, and water purification. However, between 1996 and 2020, the Philippines lost 7,934 hectares o…
ISEF · 2025
Computational Biology and Bioinformatics
Avian influenza (Bird Flu) is a highly transmissive pathogen affecting over 166 million poultry and posing significant health risks to humans. Despite progress on surface proteins, differenc…
ISEF · 2025
Computational Biology and Bioinformatics
Non-alcoholic steatohepatitis is a progressive liver disease that is frequently underdiagnosed due to its asymptomatic nature in earlier stages. It is strongly associated with the presence o…
ISEF · 2025
Computational Biology and Bioinformatics
Accurate classification of brain tumors is essential for effective patient treatment. In recent years, artificial intelligence has shown significant promise in improving medical diagnostics.…
ISEF · 2025
Computational Biology and Bioinformatics
Alzheimer’s disease (AD) affects 1 in 9 individuals aged 65+ in the U.S., with females twice as likely as males. As AD pathology begins decades before symptoms appear, early detection and in…
ISEF · 2025
Computational Biology and Bioinformatics
This project investigates the genetic mechanisms underlying Alzheimer's Disease (AD) and Limbic-Predominant Age-Related TDP-43 Encephalopathy (LATE) and their co-occurrence by analyzing diff…
ISEF · 2025
Computational Biology and Bioinformatics
Perchlorates are environmental pollutants that damage the human thyroid gland, stemming from military operations, rocket propellants, and fertilizer runoff. They also compose 0.5-1% of Marti…
ISEF · 2025
Computational Biology and Bioinformatics
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline severe enough to interfere with daily activities. Current diagnostic methods, such as…
ISEF · 2025
Computational Biology and Bioinformatics
As the annual number of amputations continues to rise, limb loss continues to impede the daily lives of over 50 million people worldwide. Though several prosthetic options are available, mos…
ISEF · 2025
Computational Biology and Bioinformatics
Climate change poses a significant threat to global ecosystems. Current mitigation strategies are inefficient and costly. Biological solutions, specifically algae, offer a promising alternat…