Browse real student projects, abstracts, and awards.
ISEF · 2023
Computational Biology and Bioinformatics
The aim of this work is to create a program capable of simulating the evolution of organisms together with geological processes. For simplicity, I have focused on the evolution of prokaryote…
ISEF · 2023
Computational Biology and Bioinformatics
There are ethnic differences in c-reactive protein and another on how the gene APOL1 can affect millions of African Americans. Genetic ancestry and socioeconomic conditions are factors to wh…
ISEF · 2023
Computational Biology and Bioinformatics Fourth Award
Drug discovery, a complex and time-consuming process, heavily relies on determining affinities between drugs and targets. With the introduction of computational methods, researchers can now…
ISEF · 2023
Computational Biology and Bioinformatics
One in twenty-six people worldwide develops epilepsy during their lifetime, including myself. Around 30% of epilepsy patients are nonresponsive to medication. It is important to identify the…
ISEF · 2023
Computational Biology and Bioinformatics
miRNAs are small, non-coding RNAs significant in numerous biological processes and disease pathways, proven heavily dysregulated in cancers, with prior literature revealing their potential a…
ISEF · 2023
Computational Biology and Bioinformatics Fourth Award
West Nile virus (WNV) is the most impactful mosquito-borne disease in the United States. Since 1999, it has caused over 2,500 deaths and has seriously harmed quality of life for thousands of…
ISEF · 2023
Computational Biology and Bioinformatics Second Award
Neural networks are fundamentally flawed. In even the most trivial tasks like digit recognition, they require tens of thousands of training examples to achieve near-human accuracy. In contra…
ISEF · 2023
Computational Biology and Bioinformatics Fourth Award
A key drawback of traditional chemotherapy drugs like cisplatin is that they target both healthy and cancerous cells and are highly toxic in high or medium doses. The Warburg Effect states t…
ISEF · 2023
Computational Biology and Bioinformatics
Rare, aggressive pediatric brain tumor ETMR is frequently misdiagnosed, reducing chances of survival. Early diagnosis is crucial due to its short average 12 month prognosis. While ETMR is ch…
ISEF · 2023
Computational Biology and Bioinformatics
Every single cell in an organism has a membrane that, in addition to being a compartmental barrier, plays a role in maintaining cell shape and function. For example, sickle cell anemia is a…
ISEF · 2023
Computational Biology and Bioinformatics Fourth Award
Purpose: Liver cancer (Hepatocellular carcinoma) is one of the most common and fatal cancers. Subtypes associated with poor outcomes need proper characterisation. “Macrotrabecular-massive He…
ISEF · 2023
Computational Biology and Bioinformatics
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease worldwide, but disease-modifying treatments are still lacking. Poly (ADP-ribose) polymerases (PARPs) consume nicotina…
ISEF · 2023
Computational Biology and Bioinformatics
Computer modeling allows for simulating unknown events of the past and the future. Since specific details about the evolutionary process are unknown, I created a model to analyze predator an…
ISEF · 2023
Computational Biology and Bioinformatics First Award
Replication errors represent two-thirds of cancer mutations. A novel subset, micro-changing short tandem repeats (mcSTRs), lack systematic examination in cancers due to complex chromosomal a…
ISEF · 2023
Computational Biology and Bioinformatics
The malaria parasite, Plasmodium, infects over 200 million people annually and causes over 500,000 deaths, primarily impacting developing countries. After a decline within the last decade, m…
ISEF · 2023
Computational Biology and Bioinformatics
The rapid mutation of COVID-19 has made the pandemic prolonged, requiring flexible implementation of virus mutation, immunity, and anti-pandemic policies. However, traditional mathematical a…
ISEF · 2023
Computational Biology and Bioinformatics Third Award
Pediatric Neuroblastoma (NB) is one of the most common cancers among infants, with 90% of its cases occurring in children under the age of five and only 50% of youth with high-risk NB surviv…
ISEF · 2023
Computational Biology and Bioinformatics
Aging is the most important risk factor associated with many diseases such as cancer and Alzheimer's disease. While many studies focused on the prediction of aging cross-sectionally, few met…
ISEF · 2023
Computational Biology and Bioinformatics
Several breast cancer patients develop resistance to multiple chemotherapeutic agents. ATP-binding cassette (ABC) family of drug transporters have been hypothesized to be potentially involve…
ISEF · 2023
Computational Biology and Bioinformatics
EEGs are an important tool used by clinicians to diagnose neurological abnormalities such as epilepsy, and by medical researchers to map the functions of different components of the brain. H…
ISEF · 2023
Computational Biology and Bioinformatics
In this project, we propose the design and implementation of a new programming language that is specifically tailored for bioinformatics and computational science. The language has a simple…
ISEF · 2023
Computational Biology and Bioinformatics Fourth Award
Cancer's molecular heterogeneity and complexity pose significant treatment challenges. Drug combinations have recently been employed to enhance cancer therapy due to their synergistic effect…
ISEF · 2023
Computational Biology and Bioinformatics Second Award
Cells have evolved the process of translational regulation to rapidly fine-tune protein expression to suit intracellular needs. Ribosome velocity during translation elongation is a key contr…
ISEF · 2023
Computational Biology and Bioinformatics Second Award
The spread and transmission of SARS-CoV-2 and other viruses can lead to various mutations that cause significant spikes in infections. It is essential for researchers to study virus genome s…
ISEF · 2023
Computational Biology and Bioinformatics
CARM1 is a methyltransferase that methylates the BAF155 in the SWI/SNF protein complex, leading to cell proliferation and migration via the c-MYC pathway. SKI-73. EZM 2302, and TP-064 are th…
ISEF · 2023
Computational Biology and Bioinformatics
The role of deep learning in the recognition of morphological structures in histopathological data is heavily stunted by extreme variations that may exist in the datasets that these deep lea…
ISEF · 2023
Computational Biology and Bioinformatics
GABAA receptor (GABAAR), a pentameric ligand-gated ion channel, is activated by GABA, a major inhibitory neurotransmitter in the human brain. GABAAR dysfunction is implicated in several CNS…
ISEF · 2023
Computational Biology and Bioinformatics Third Award
Aortic aneurysms have increased in the past two decades and affect about 2.9 million people. Although surgical treatments have become increasingly sophisticated, there is a lack of efficient…
ISEF · 2023
Computational Biology and Bioinformatics
Developments in microscopy imaging have allowed for in depth study of biological systems at a level never previously reached. One such method is RNA fluorescence in situ hybridization (FISH)…
ISEF · 2023
Computational Biology and Bioinformatics Third Award
Litsea cubeba (Lauraceae) is a woody plant which is widely distributed in Vietnam. Its fruit essential oil (FEO) showed a potent effect on the central nervous system (CNS). However, the neur…