Browse real student projects, abstracts, and awards.
ISEF · 2022
Computational Biology and Bioinformatics
The lack of effective treatments for many diseases increases the demand for new drug discovery. Consequently, the drug repositioning (DR) strategy is widely used. Drug-Target Interaction (DT…
ISEF · 2022
Computational Biology and Bioinformatics
As a common side-effect of aminoglycoside antibiotics and cancer-related medications, drug-induced hearing loss (ototoxicity) can severely deplete inner ear hair cells and cause long-term se…
ISEF · 2022
Computational Biology and Bioinformatics
Pineoblastoma (PB) is a malignant brain tumor that originates in the pineal gland. Patients diagnosed with PB experience headaches, sleepiness, vomiting, and vision changes. This epidemiolog…
ISEF · 2022
Computational Biology and Bioinformatics
Human endogenous retroviruses (HERVs) are remnants of germline infections that constitute 5-8% of the human genome. HERVs have been suggested as potential oncogenic drivers. One HERV, HML-6…
ISEF · 2022
Computational Biology and Bioinformatics
Particulate matter consists of both solid particles and liquid droplets. PM2.5 are particles 2.5 micrometers in diameter or less. Internal combustion engines, coal-fired power plants, constr…
ISEF · 2022
Computational Biology and Bioinformatics Fourth Award
Patient-Derived Xenografts (PDX), a novel in vivo cancer modeling technique used in personalized medicine, has been shown to bypass typical constraints of in vitro tumor cell culture models.…
ISEF · 2022
Computational Biology and Bioinformatics Second Award
Tauopathies are a group of progressive disorders that are characterized when a protein, called tau, builds up significantly in an individual's brain. New breakthrough research has demonstrat…
ISEF · 2022
Computational Biology and Bioinformatics
With the application of machine learning techniques to various fields (for example, computer vision and healthcare), the problem of interpretability is gaining importance. Building transpare…
ISEF · 2022
Computational Biology and Bioinformatics Third Award
Despite being one of the most common diseases in the world, Alzheimer’s disease is misdiagnosed at a high rate of 12% to 23% [1]. Current state-of-the-art machine learning models for Alzheim…
ISEF · 2022
Computational Biology and Bioinformatics
This experiment aims to see the connection between genes downregulated by the Forkhead Box O1 protein (FOXO1) in skeletal myocytes and breast cancer. FOXO1 is observed to be significantly up…
ISEF · 2022
Computational Biology and Bioinformatics Second Award
With the lowest 5-year survival rate (9%) among all types of cancer, pancreatic cancer is considered one of the most lethal diseases in the world. Current conventional treatments often fail…
ISEF · 2022
Computational Biology and Bioinformatics
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is a viral disease that has caused a major global pandemic. There are many developing treatments for SARS-CoV2 including vaccines…
ISEF · 2022
Computational Biology and Bioinformatics
Embryonic development is a universal process that is elucidated amongst healthcare professionals and researchers in the field of obstetrics. During particular stages of development, families…
ISEF · 2022
Computational Biology and Bioinformatics
With thousands of Mendelian-inherited diseases, new bioinformatics technology such as WES has been implemented to identify causal genes and variants within patients. Even with modern technol…
ISEF · 2022
Computational Biology and Bioinformatics
Despite the immense promise of cancer immunotherapies, there are significant challenges to overcoming treatment resistance and improving efficacy. Strategies such as the combination immunoth…
ISEF · 2022
Computational Biology and Bioinformatics
Nearly seven million individuals in the U.S. have Essential Tremor (ET), making it one of the most common neurological disorders. Current ET research aligns it with a Purkinje cell disorder…
ISEF · 2022
Computational Biology and Bioinformatics
Immunotherapy activates the body’s immune response against cancers by inhibiting interactions between cancer cells and T-cells (cells that fight against foreign substances or in this case, c…
ISEF · 2022
Computational Biology and Bioinformatics
Large biomedical datasets routinely consist of more data points than can be displayed faithfully on a computer monitor. Computer screens are incapable of representing high-volume datasets wi…
ISEF · 2022
Computational Biology and Bioinformatics
As the Coronavirus continues to spread globally, different mutations arise. These variants often take long periods of time until being discovered, resulting in large spikes of infection. Thi…
ISEF · 2022
Computational Biology and Bioinformatics
Many actions in everyday life are becoming more automated, but critical tasks continue to require human oversight. Automatic driving systems automate repetitive functions through the use of…
ISEF · 2022
Computational Biology and Bioinformatics Second Award
Background: Cavendish banana production is seriously threatened by Fusarium wilt tropical race 4, characterized by leaf decay patterns detectable through image recognition technology. Althou…
ISEF · 2022
Computational Biology and Bioinformatics
Alcoholism is a leading cause of premature death and disability globally. Alcohol use has profound mental and physical impacts including impaired decision-making skills and diseases related…
ISEF · 2022
Computational Biology and Bioinformatics Fourth Award
Missense mutations are a form of genetic variant that result in substitutions of amino acids in protein sequences. These mutations account for approximately half of human inherited diseases…
ISEF · 2022
Computational Biology and Bioinformatics
Neurodegenerative diseases and cancerous brain tumors cause millions of patients worldwide to be fatally ill each year. Current diagnosis and treatment of these neurological conditions take…
ISEF · 2022
Computational Biology and Bioinformatics
Accurate Age-At-Death (AAD) estimation is integral in determining biological profiles, specifically of unidentified and skeletonized human remains. To date, AAD estimation relies primarily o…
ISEF · 2022
Computational Biology and Bioinformatics
Antibiotic-resistant diseases, orphan diseases, and disease outbreaks are the cause of millions of deaths annually. Inefficient treatment of these diseases, alongside other diseases, contrib…
ISEF · 2022
Computational Biology and Bioinformatics
Synthesizability—the ability to build a compound using purchasable starting materials—is a vital consideration in computer-aided drug discovery; virtually created molecules are of no value i…
ISEF · 2022
Computational Biology and Bioinformatics
Current genetic databases provide a wealth of information accessible to the general population, but are primarily designed for usage by professionals already experienced in the fields of gen…
ISEF · 2022
Computational Biology and Bioinformatics
Drug development processes are burdened with a critical problem that only 9.6% of tested drugs are qualified for commercialization while each clinical trial phase of experimental drugs heavi…
ISEF · 2022
Computational Biology and Bioinformatics
Protein-ligand binding is at the heart of interaction between human or pathogen cells and ligand molecules. Among ligands, drug molecules usually bind specifically to their target proteins a…