38,465 real projects from ISEF, the Canada-Wide Science Fair, JSHS, AJAS, the Calgary Youth Science Fair and the California Science & Engineering Fair — searchable by meaning, and filterable by fair, year, category and award.
ISEF · 2021
Computational Biology and Bioinformatics
Breast cancer is the most common form of cancer in women, and tobacco smoke has been classified as a carcinogen by the International Agency for Research on Cancer. While nicotine is known to…
ISEF · 2021
Computational Biology and Bioinformatics First Award
The epidermal growth factor receptor (EGFR) family proteins, consisting of HER1-4, are the most prominent causes of various human cancers, including breast, gastric, esophagus, lung, pancrea…
ISEF · 2021
Computational Biology and Bioinformatics
Due to technological advancements in artificial intelligence, computers can charter the path/course for a multitude of proteins/enzymes and their metabolites in order to diagnose and/or cure…
ISEF · 2021
Computational Biology and Bioinformatics
Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant condition at risk of progressing to multiple myeloma, a type of incurable blood cancer, and other type of plasma c…
ISEF · 2021
Computational Biology and Bioinformatics Third Award
Computationally determining protein structure and function is promising, but researchers currently lack a complete end-to-end open-source tool capable of sequence alignment, de novo protein…
ISEF · 2021
Computational Biology and Bioinformatics
Gene Enrichment Analysis is used to analyze the relationship between genes and known biological annotations. The lack of a versatile Gene Enrichment Tool has been a major hurdle throughout b…
ISEF · 2021
Computational Biology and Bioinformatics
This project aimed to determine the most effective and economically sustainable method of reducing the burden of meningococcal meningitis within the Meningitis Belt of Sub-Saharan Africa. Th…
ISEF · 2021
Computational Biology and Bioinformatics Third Award
Myopathies are skeletal muscle disorders characterized by chronic muscle weakness, which are frequently diagnosed using electromyography (EMG) studies. Automating the diagnosis of myopathies…
ISEF · 2021
Computational Biology and Bioinformatics
BETA-site amyloid precursor protein cleaving enzyme 1 (BACE1) has medical significance for forming a drug target to treat Alzheimer's disease (AD). The activity of BACE1 toward amyloid precu…
ISEF · 2021
Computational Biology and Bioinformatics
Epilepsy is generally diagnosed using electroencephalograms, or EEGs, which detect the electrical activity in a person's brain. Signals recorded from neurological tissue are extremely noisy,…
ISEF · 2021
Computational Biology and Bioinformatics
Recent advances show that the 14-3-3zeta protein is a unique regulator of IL-17A signal transduction. IL-17A signal transduction triggers two, 14-3-3zeta-TRAF5 and 14-3-3zeta-TRAF6-dependent…
ISEF · 2021
Computational Biology and Bioinformatics Fourth Award
Severe acute respiratory syndrome (SARS-CoV-2), has caused the global infectious disease COVID-19. Cases of COVID-19 infections increased rapidly along with high mortality rates and therefor…
ISEF · 2021
Computational Biology and Bioinformatics
Prions, also known as pathogenic neuronal agents, are groups of proteins found clustered in the brain and are responsible for regulatory processes including neuritogenesis, neuronal homeosta…
ISEF · 2021
Computational Biology and Bioinformatics
Programmed cell death-1 (PD-1) is an inhibitory receptor that provides a checkpoint against autoimmunity. The PD-1:PD-L1 signalling pathway inhibits T cell function, which allows cancer cell…
ISEF · 2021
Computational Biology and Bioinformatics
Aim: To identify candidate microRNAs (miRNAs) or genes with potential to induce endometrial receptivity with different methods of meta-analyses Materials and Methods: Chapter 1: Partial corr…
ISEF · 2021
Computational Biology and Bioinformatics
The recent COVID-19 pandemic caused by SARS-CoV-2 has threatened billions of lives across the globe and demands immediate attention. Although vaccines have recently started deployment, there…
ISEF · 2021
Computational Biology and Bioinformatics
Ebola virus disease (EVD) causes hemorrhagic fever infection with a mortality rate of up to 90%. Current treatments, mostly experimental, require medical equipment and facilities often not a…
ISEF · 2021
Computational Biology and Bioinformatics Fourth Award
Klebsiella pneumoniae exhibits among the highest rates of antibiotic resistance and is currently the main cause of carbapenem resistant infections, yet there are no clinically effective trea…
ISEF · 2021
Computational Biology and Bioinformatics
Alzheimer’s disease is a progressive disease causing deterioration of neurons in the brain, leading to dementia and eventual death. Diagnosis of Alzheimer’s conventionally consists of a comb…
ISEF · 2021
Computational Biology and Bioinformatics
Unilateral incompatibility (UI) occurs in an interspecific cross when the flower pistil terminates pollen tube formation prematurely before fertilization. UI occurs in one direction, the opp…
ISEF · 2021
Computational Biology and Bioinformatics
Recent research in the treatment and prevention of disease has become dominated by a relatively new and revolutionary technique: mRNA. Although initially used to develop cancer prophylactics…
ISEF · 2021
Computational Biology and Bioinformatics
Since December 2019, a novel coronavirus known as COVID-19 has plagued the world. Currently, Chest CT imaging is used alongside the reverse transcription polymerase chain reaction test (RT-P…
ISEF · 2021
Computational Biology and Bioinformatics
Targeted therapies for glioblastoma multiforme (GBM) have low success rates in clinical trials and fail to target specific disease-causing mutations, partially due to the exclusive use of ge…
ISEF · 2021
Computational Biology and Bioinformatics
The current methods for drug development against a target disease are not cost-effective. The process is not efficient and has a high failure rate. It can take up to 12 years to design, crea…
ISEF · 2021
Computational Biology and Bioinformatics
This paper proposes a novel Open Time to Event (OTTE) model to derive open population estimates of a target marine species, in a chosen sampling region with RUV cameras present in it. It use…
ISEF · 2021
Computational Biology and Bioinformatics First Award
Adverse drug reactions (ADRs) represent a significant threat to public health, causing an estimated 100,000 deaths annually in the U.S., but accurate predictions of ADRs caused by drug-drug…
ISEF · 2021
Computational Biology and Bioinformatics Second Award
More than 95% of the approximately 7000 orphan diseases in the world do not have effective treatments, and since orphan diseases are conditions that affect a limited population, there is lit…
ISEF · 2021
Computational Biology and Bioinformatics
Purpose: Covid-19, a viral global pandemic caused by the SARS-CoV-2 virus caused 2.72 million deaths (as of 03-22-21) worldwide and more than 543,000 deaths in the United States. The purpose…
ISEF · 2021
Computational Biology and Bioinformatics Fourth Award
Cancer stem cells (CSCs) are subpopulations of cancerous cells that are theorized to be the cause of tumor initiation and relapse. CSCs are especially dangerous because they are resistant to…
ISEF · 2021
Computational Biology and Bioinformatics
The National Cancer Institute reported 9.5 million cancer-related deaths in 2018. A challenge in improving treatment is resistance in genetically unstable cells. The purpose of this study is…