Browse real student projects, abstracts, and awards.
ISEF · 2021
Computational Biology and Bioinformatics Fourth Award
In recent decades, there's been an alarming increase in bacterial evasion of antibiotic treatments, necessitating an improved understanding of resistance, tolerance, and persistence. Resista…
ISEF · 2021
Computational Biology and Bioinformatics
Early detection and treatment of colorectal cancer is vital to prevent metastasis, but past models lack a cohesive pipeline from diagnosis to treatment to determine biomarkers and suggest tr…
ISEF · 2021
Computational Biology and Bioinformatics
If adjacent genes in the same direction (Tail-to-Head, T2H) are located very close to each other (at a distance of several hundred base pairs) or partially overlapping, chimeric transcripts…
ISEF · 2021
Computational Biology and Bioinformatics
As of April 9th, 2021, there have been over 31 million cases of COVID-19 in the United States alone. Simultaneously, an estimated 15% of U.S. adults suffer from Chronic Kidney Disease (CKD).…
ISEF · 2021
Computational Biology and Bioinformatics Fourth Award
My project aims to identify a therapy to treat COVID-19 infections using gene expression and a computer-assisted approach. My computer program, AMiF (Augmented miRNA Filtration Model) works…
ISEF · 2021
Computational Biology and Bioinformatics
With major outbreaks in over 150 countries, the COVID-19 pandemic has had a devastating effect on public health, daily life, and the global economy. Absent a vaccine or therapeutic treatment…
ISEF · 2021
Computational Biology and Bioinformatics
While pancreatic cancer is a deadly disease that is difficult to diagnose at an early stage, early diagnosis yields a much higher survival rate, making it key for treatment. With an increase…
ISEF · 2021
Computational Biology and Bioinformatics
Influenza virus is a single-stranded negative RNA virus, divided into three types, A, B, and C (Shao, Li, Goraya, Wang, & Chen, 2017). This research focused on influenza type A, which mainly…
ISEF · 2021
Computational Biology and Bioinformatics Third Award
Despite major advances in immunosuppression, thousands of transplanted organs are still rejected, endangering the lives of many patients. Traditional approaches to understanding transplant r…
ISEF · 2021
Computational Biology and Bioinformatics
Background: Alzheimer’s Disease pathogenesis is associated with the deposition of amyloid-beta (AB) protein aggregates in the brain. No treatment has been proposed to degrade pre-oligomeric…
ISEF · 2021
Computational Biology and Bioinformatics
Vestibular schwannomas, also known as acoustic neuromas, result from an overproduction of schwann cells on the eighth cranial nerve. This benign brain tumor affects hearing and balance. Data…
ISEF · 2021
Computational Biology and Bioinformatics
To research the spread of the novel coronavirus, and prevent and control the widespread of the virus, this project investigated the spread of the novel coronavirus pneumonia epidemic from th…
ISEF · 2021
Computational Biology and Bioinformatics
The purpose of this experiment is to discover how the percent of animals marked and the sample size affects the accuracy of the capture-recapture method. To simulate if the percent of marked…
ISEF · 2021
Computational Biology and Bioinformatics Second Award
Multiple Sclerosis (MS) is a neuroinflammatory demyelinating disease that affects over 2,000,000 individuals worldwide. Although the exact etiology of the disease is unknown, the main sympto…
ISEF · 2021
Computational Biology and Bioinformatics
During the initial spread of COVID-19, countries varied in their ability to control the virus. Science shows this variability is in part due to sociocultural factors. One sociocultural facto…
ISEF · 2021
Computational Biology and Bioinformatics Fourth Award
The goal of this project was to construct a working RNA-sequencing analysis pipeline that would (1) produce visuals to demonstrate differentially expressed genes via PCA plots, correlation a…
ISEF · 2021
Computational Biology and Bioinformatics
Mutations on the SARS-CoV-2 spike protein have gained increasing attention. However, its mutation pattern in different geographic locations within a country has not been investigated. In thi…
ISEF · 2021
Computational Biology and Bioinformatics
Bainbridge-Ropers Syndrome is a rare autosomal dominant neurodevelopmental disease characterized by predicted truncating mutations in the ASXL3 gene. Around 200 children have been diagnosed…
ISEF · 2021
Computational Biology and Bioinformatics
Dementia is a disease that impairs the brain it causes memory loss and interferes with a person’s ability to think and make judgments. Every year 10 million people get diagnosed with dementi…
ISEF · 2021
Computational Biology and Bioinformatics
Breast cancer is the most common form of cancer in women, and tobacco smoke has been classified as a carcinogen by the International Agency for Research on Cancer. While nicotine is known to…
ISEF · 2021
Computational Biology and Bioinformatics First Award
The epidermal growth factor receptor (EGFR) family proteins, consisting of HER1-4, are the most prominent causes of various human cancers, including breast, gastric, esophagus, lung, pancrea…
ISEF · 2021
Computational Biology and Bioinformatics
Due to technological advancements in artificial intelligence, computers can charter the path/course for a multitude of proteins/enzymes and their metabolites in order to diagnose and/or cure…
ISEF · 2021
Computational Biology and Bioinformatics
Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant condition at risk of progressing to multiple myeloma, a type of incurable blood cancer, and other type of plasma c…
ISEF · 2021
Computational Biology and Bioinformatics Third Award
Computationally determining protein structure and function is promising, but researchers currently lack a complete end-to-end open-source tool capable of sequence alignment, de novo protein…
ISEF · 2021
Computational Biology and Bioinformatics
Gene Enrichment Analysis is used to analyze the relationship between genes and known biological annotations. The lack of a versatile Gene Enrichment Tool has been a major hurdle throughout b…
ISEF · 2021
Computational Biology and Bioinformatics
This project aimed to determine the most effective and economically sustainable method of reducing the burden of meningococcal meningitis within the Meningitis Belt of Sub-Saharan Africa. Th…
ISEF · 2021
Computational Biology and Bioinformatics Third Award
Myopathies are skeletal muscle disorders characterized by chronic muscle weakness, which are frequently diagnosed using electromyography (EMG) studies. Automating the diagnosis of myopathies…
ISEF · 2021
Computational Biology and Bioinformatics
BETA-site amyloid precursor protein cleaving enzyme 1 (BACE1) has medical significance for forming a drug target to treat Alzheimer's disease (AD). The activity of BACE1 toward amyloid precu…
ISEF · 2021
Computational Biology and Bioinformatics
Epilepsy is generally diagnosed using electroencephalograms, or EEGs, which detect the electrical activity in a person's brain. Signals recorded from neurological tissue are extremely noisy,…
ISEF · 2021
Computational Biology and Bioinformatics
Recent advances show that the 14-3-3zeta protein is a unique regulator of IL-17A signal transduction. IL-17A signal transduction triggers two, 14-3-3zeta-TRAF5 and 14-3-3zeta-TRAF6-dependent…