38,465 real projects from ISEF, the Canada-Wide Science Fair, JSHS, AJAS, the Calgary Youth Science Fair and the California Science & Engineering Fair — searchable by meaning, and filterable by fair, year, category and award.
ISEF · 2022
Computational Biology and Bioinformatics
Synthesizability—the ability to build a compound using purchasable starting materials—is a vital consideration in computer-aided drug discovery; virtually created molecules are of no value i…
ISEF · 2022
Computational Biology and Bioinformatics
Current genetic databases provide a wealth of information accessible to the general population, but are primarily designed for usage by professionals already experienced in the fields of gen…
ISEF · 2022
Computational Biology and Bioinformatics
Drug development processes are burdened with a critical problem that only 9.6% of tested drugs are qualified for commercialization while each clinical trial phase of experimental drugs heavi…
ISEF · 2022
Computational Biology and Bioinformatics
Protein-ligand binding is at the heart of interaction between human or pathogen cells and ligand molecules. Among ligands, drug molecules usually bind specifically to their target proteins a…
ISEF · 2022
Computational Biology and Bioinformatics
The pandemic brought about by Covid-19 has greatly disrupted the world. The virus has different mutations that can be seen in the population, but there are also many mutations that exist wit…
ISEF · 2022
Computational Biology and Bioinformatics
When exposed to antibiotics for long enough, a bacterial population can evolve to become resistant. This prompts the creation of innovative therapeutics such as bacteriophage therapy. 'Phage…
ISEF · 2022
Computational Biology and Bioinformatics
Protein-protein interactions guide essential life processes, including DNA repair. Nucleolin has many roles, but few efforts have been made to fully characterize its role in DNA repair. In t…
ISEF · 2022
Computational Biology and Bioinformatics
Infectious diseases are a leading cause of mortality worldwide. Among the major pathogens, SARS-CoV-2 is a coronavirus causing the current COVID-19 pandemic. MERS-CoV and SARS-CoV also belon…
ISEF · 2022
Computational Biology and Bioinformatics
Isoniazid (INH) is a ?rst line drug for the treatment of Tuberculosis, a disease that causes 1.5 million deaths per year. This drug has high e?cacy in TB-treatment, but can also lead to live…
ISEF · 2022
Computational Biology and Bioinformatics Third Award
Around 3.8 million women in the US are diagnosed with breast cancer. In terms of the survival rate, late or misclassified diagnosis decreases an individual’s chance of survival from 90% to j…
ISEF · 2022
Computational Biology and Bioinformatics Third Award
Features with rare states, such as rare genetic variants and low frequency amino acid mismatches, pose a surrounding their role in predicting outcomes such as disease phenotype. Bins of rare…
ISEF · 2022
Computational Biology and Bioinformatics First Award
Replication errors represent two-thirds of cancer mutations. A novel replication error subset, recurrent repeat contractions (rRCs), lack systematic examination in cancers due to complex amp…
ISEF · 2022
Computational Biology and Bioinformatics Third Award
The speed of ribosome movement along an mRNA transcript is a critical determinant of protein synthesis. Ribosome pause sites, or regions along an mRNA transcript where translating ribosomes…
ISEF · 2022
Computational Biology and Bioinformatics
Motor neurons are the essential cells connecting the brain and muscles, translating our thoughts and needs into actions and response. Here, we analyze a previously published dataset to explo…
ISEF · 2022
Computational Biology and Bioinformatics
The purpose of this experiment is to determine the relationship of breastfeeding and other social and economic factors to infant mortality on the Louisiana and national level. The researcher…
ISEF · 2022
Computational Biology and Bioinformatics
Each year, over two million people globally are afflicted by potentially life-threatening antibiotic-resistant infections, and many scientists believe that antibiotic-resistant superbugs may…
ISEF · 2022
Computational Biology and Bioinformatics Fourth Award
Cancer is one of the deadliest illnesses in the world, and to find a cure for cancer, information must be obtained on the human body’s response to tumors. The purpose of this study was to id…
ISEF · 2022
Computational Biology and Bioinformatics
Cancer metastasis poses a significant threat to global public health, accounting for an estimated 90% of cancer-related deaths, due to a lack of effective anti-metastatic agents. The overexp…
ISEF · 2022
Computational Biology and Bioinformatics
As burgeoning crises have exposed failures of the drug discovery cycle - an inability to quickly and effectively develop new drugs - artificial intelligence-based drug repositioning models a…
ISEF · 2021
Computational Biology and Bioinformatics Fourth Award
Diversity generating retroelements (DGRs) are genetic elements that promote hyper mutations in specific regions of the genome. The targeted mutations of DGRs allow positive traits to manifes…
ISEF · 2021
Computational Biology and Bioinformatics
This study aims to develop a network for prominent chronic illnesses and neurodegenerative diseases, factoring in preexisting conditions, lifestyle decisions, and an individual’s environment…
ISEF · 2021
Computational Biology and Bioinformatics Third Award
Amyloid-beta is an intrinsically disordered protein involved in neurodegenerative disorders. Previously, amyloid-beta was considered “undruggable” due to its shape-shifting properties. Howev…
ISEF · 2021
Computational Biology and Bioinformatics Fourth Award
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder characterized by death of upper and lower motor neurons and progressive paralysis of the extremities. ALS is a compl…
ISEF · 2021
Computational Biology and Bioinformatics Second Award
Our survival depends on the brain's adaptation of information processing to changing cognitive demands; this ability stems from the interactions of specialized brain networks. At rest, netwo…
ISEF · 2021
Computational Biology and Bioinformatics
??-helical coiled coils are protein substructures that play important roles in a wide range of biological events. Some types of coiled coils are used by various viruses (eg SARS-CoV2) to ent…
ISEF · 2021
Computational Biology and Bioinformatics
The microscopic structure of bone contributes to its resistance to crack propagation and high damage tolerance under mechanical loading. In everyday life, bone accumulates tiny fractures, ca…
ISEF · 2021
Computational Biology and Bioinformatics
Neurodegenerative diseases are one of the highest causes of death within the world. The WHO reported in 2016 that Alzheimer’s Disease and dementia were the 5th highest cause of death interna…
ISEF · 2021
Computational Biology and Bioinformatics
This research studied the gene expression profiles of small nuclear RNA (snRNA) and small nucleolar RNA (snoRNA) in Preeclampsia (PE), compared to term and idiopathic (iPTB) patients. The pu…
ISEF · 2021
Computational Biology and Bioinformatics Third Award
The cocktail party problem renders conversation difficult for hard-of-hearing individuals in multi-speaker environments. Current hearing aids cannot amplify the primary speaker's voice alone…
ISEF · 2021
Computational Biology and Bioinformatics
Recent rise in COVID-19 cases has highlighted the need for effective and targeted measures to reduce the spread of the virus. Consequently, app-based tracing strategies have been proposed as…