Computational Biology and Bioinformatics (inferred)
Drug discovery relies on an accurate assessment of how a compound binds to a target and how that may influence biological function. The recent revolution in AI has now significantly expedite…
Computational Biology and Bioinformatics (inferred)
Neonatal seizures cause significant morbidity and mortality, both acutely and in the long term, contributing to adverse neurodevelopmental outcomes. Traditional EEG seizure detection by huma…
Computational Biology and Bioinformatics (inferred)
Lymphoma arises from the uncontrolled proliferation of lymphocytes, often triggered by genetic mutations. Standard treatments such as chemotherapy and radiation therapy face limitations due…
Computational Biology and Bioinformatics (inferred)
Pharmacokinetic (PK) modeling plays a crucial role in developing and optimizing drug therapies, enabling the prediction of drug concentration in the plasma over time and thus informing dosag…
Computational Biology and Bioinformatics (inferred)
Organ rejection is a dangerous medical complication that can occur after an organ transplant. Currently, all transplant patients are prescribed life-long immunosuppressors to decrease the ri…
Computational Biology and Bioinformatics (inferred)
The continued growth of antibiotic resistance and the slowing of antibiotic discovery poses a large challenge in modern medicine. Recent advances in Artificial intelligence (AI) technologies…
Computational Biology and Bioinformatics (inferred)
Alzheimer's disease (AD), a progressive neurodegenerative disorder affecting over 50 million globally, has seen limited success with FDA-approved treatments targeting amyloid beta (Aβ) aggre…
Computational Biology and Bioinformatics (inferred)
Breast cancer affects 2.3 million women annually with the five-year survival rate for triple-negative-breast-cancer (TNBC) around 12%. Current immunotherapy treatments are effective only in…
Computational Biology and Bioinformatics (inferred)
Alzheimer’s disease (AD), a neurodegenerative disease inflicting nearly 6 million people in the United States, is characterized by molecular and cellular changes in the brain that result in…
Computational Biology and Bioinformatics (inferred)
This research project explores the sophisticated integration of omics and computational analysis techniques with a focus on exome sequences. Leveraging the Arcus computational framework, our…
Computational Biology and Bioinformatics (inferred)
This project evaluates several climate-based vector-borne disease transmission models with particular emphasis on the Parham-Michael climate-driven model for malaria transmission dynamics. I…
Computational Biology and Bioinformatics (inferred)
Antimicrobial peptides (AMPS) have a broad spectrum of antimicrobial activities against bacteria, fungi, and even viruses, and there have been over 5000 AMPs discovered. Individual peptides…
Computational Biology and Bioinformatics (inferred)
“Thought-Code”/” Blink-Code” Part II: Analyzing EEGs through dimensionality reduction for EEG classification Sarvesh R. Babu duPont Manual High School Abstract The focus of the project is to…
Computational Biology and Bioinformatics (inferred)
Polygenic developmental diseases affecting humans like autism spectrum disorder often have unknown causes and are difficult to cure. Gene expression and regulation is among the most importan…
Computational Biology and Bioinformatics (inferred)
Epilepsy is a chronic brain disorder affecting 1% of the population worldwide. Its primary symptoms, seizures, occur without warning and can often be dangerous. Epilepsy is diagnosed with th…
Computational Biology and Bioinformatics (inferred)
Mouse models serve as a readily available base for experimentation in neurodegenerative drug development. However, less than 10% of drugs that have shown success in mouse-based preclinical t…
Computational Biology and Bioinformatics (inferred)
Accurately determining the abundance of oncogenes and tumor suppressors is necessary to understand the pathogenesis and treatment of cancer patients. However, low purity, tumor heterogeneity…