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ALS-SynAegis: A Molecular Dynamics Study on TDP-43 Aggregation to Prevent Amyotrophic Lateral Sclerosis Onset

Biochemistry Fourth Award

Amyotrophic Lateral Sclerosis is a devastating neurodegenerative disease characterized by progressive muscle atrophy, leading to an inability to move the limbs and, in extreme cases, being u…

Alterations in Neuromodulatory Proteins in Single APP Knock-in Mice Assessed Following Ketamine Therapy

Biochemistry

Alzheimer's disease (AD) poses a global health challenge, necessitating a deeper exploration of its etiology for effective interventions. This study investigates the impact of ketamine, an N…

Analysis of Novel Multi-Enzyme Formulation's Synergistic Implications for the Enhanced Interventional Disruption of E. coli Biofilms

Biochemistry

Biofilms are intricate and stratified bacterial communities anchored on various surfaces, such as medical devices, surgical equipment, teeth plaque, etc. Contemporary treatment methods - ant…

Analyzing Per- and Polyfluoroalkyl Substances (PFAS) Through Atomistic Simulations

Chemistry First Award

Per- and polyfluoroalkyl substances (PFAS), a class of highly fluorinated hydrocarbons, pose global contamination and pollution concerns due to both their toxicity and their potential to inc…

A Novel Approach to Characterizing Pathogenicity of SLC25A13 Variants in Cancer

Biochemistry First Award

A hallmark of cancer is the rewiring of cellular metabolism to meet proliferative needs. Citrin protein (transcribed from the human SLC25A13 gene) is a mitochondrial carrier involved in the…

A Novel Pattern of Reactive Crystallization of Calcium Carbonate Formed in Agarose Gel

Chemistry

The formation or dissolution of CaCO3 in nature, influenced by carbonate equilibrium, is impacted by rising atmospheric carbon dioxide levels. The Liesegang phenomenon, a self-organization p…

A Novel Role for aIIbß3 in the Development of Procoagulant Platelets via Phosphatidylserine (PS) Exposure

Biochemistry

Platelets play a vital role in hemostasis, a critical physiological response to prevent bleeding from vascular injury. Activated platelets can be divided into two distinct subpopulations: pr…

Antipodal Algae: Engineering Energy Solutions for a South Pacific Island

Biochemistry Fourth Award

As the emission of carbon dioxide into our atmosphere continues to contribute to climate change, the search for cleaner energy sources prevails. Using algae as a biofuel can replace the use…

AP Using Machine Learning Algorithms To Predict Whether Phytochemicals Are Cancerous or Anti-Cancerous

Biochemistry

Chemicals found in plants can be beneficial in the treatment and prevention of cancer, however, sometimes they can also be carcinogenic. My project aims to understand if the values of select…

A Study of the Power Generation Efficiency of Natural Dyes in Daily Life on Dye-Sensitized Solar Cell (DSSC) According to Chemical Structures

Chemistry

This research aims to produce eco-friendly and economically efficient DSSC that can replace even chemical dyes by using vegetable extracts and household food waste as natural dyes. To find t…

Biodegradable Agricultural Mulch Films From Wastepaper Pulp and Calcium Alginate

Chemistry

Traditional petroleum-based plastic mulch films are widely used in agriculture because of their superior weed and pest prevention as well as their longevity, but they depend on non-renewable…

Biomedically Functional Sugars: Transforming Glycan-Based Drug Design Through Streamlined Methods and Novel Metabolic Glycan Tracking

Biochemistry

Complex sugars known as Glycosaminoglycans (GAGs) play a vital role in nearly all biological processes, from wound healing to the progression of diseases such as cancer and Alzheimer's. They…

BioPower: A Biochemical Redox-Flow Battery

Chemistry Fourth Award

Climate change drives governments around the world to switch from carbon-based energy to renewable sources. Wind and solar power are very popular, yet storing enough energy for night or time…

B.O.P.I : Black Pepper, Oregano and Pineapple Peel Insecticide as an Novel, Cost-Effective and Eco-friendly Fumigant to Eradicate Sitophilus oryzae

Chemistry Third Award

Sitophilus oryzae, commonly known as the rice weevil, is a stored grain pest responsible for potentially destroying up to 90% of stored grain worldwide. In an effort to eradicate it, various…

Casein Hydrolysate and the Effects on the Heart Rate of Daphnia magna

Biochemistry

An essential component of human diets is dairy because it has a unique effect it has on the human body due to a protein called casein. This protein has angiotensin receptor blockers that aff…

Characterization of Antimicrobials From the Soil Bacterium Xenorhabdus szentirmaii

Biochemistry Fourth Award

Antimicrobial resistance(AMR) is a global health threat and the discovery of new antimicrobial compounds has been limited in the past four decades. New antimicrobials with new functions are…

Chemical Analyses of Archeological Pottery Sherds Found Along the Colorado River, Grand Canyon, Arizona

Chemistry

My Zuni ancestors lived in the Grand Canyon long ago. A Zuni medicine man pointed out many Zuni features to my mentor on a Grand Canyon Rafting Tour, sponsored by the Grand Canyon Conservanc…

Chemical Modification of Acetaminophen to Decrease Liver Toxicity

Chemistry Third Award

Each week, over 60 million individuals consume acetaminophen in the U.S. alone. Despite global reliance for its analgesic & antipyretic (pain & fever relief) properties in medications, aceta…

Designing a Cost-Effective Lateral Flow Assay for Hypercalcemia Detection and Formulation of Therapeutic Supplements to Modulate Serum Calcium Concentrations

Biochemistry

Hypercalcemia is a condition where the levels of calcium in the blood are greater than normal, having the ability to weaken bones, create kidney stones, and disrupt the heart and brain conne…

Designing Drugs by Artificial Intelligence: Novel Curcuminoids for the Treatment of Papillary Renal Cell Carcinoma Type II (PRCC2)

Chemistry

Papillary type 2 renal cell carcinoma (CCRp2) is an aggressive type of kidney cancer that has been growing more rapidly in cells and can spread to other organs of the body. Curcumin, a compo…

Design, Synthesis and Biological Evaluation of a Hybrid Boronic Acid-Quinolinone Derivative as a Novel Acid Ceramidase Inhibitor To Target Breast Cancer

Biochemistry

Breast cancer is one of the most common cancers accounting for 12.5% of all annual new cancer cases worldwide. Overall survival of the patients is limited for aggressive breast cancer phenot…

Developing a Polyethylene Glycol Hydrogel Based Controlled Delivery System Using the Alkyl Radical Initiator AIPH as an Antitumor Therapy

Biochemistry

Hydrogels are three-dimensional polymers that can serve as a strategy for sustained treatment of tumors by slowly releasing compounds into an area. By adding compounds such as AIPH and the n…

Development of a Photocaged Cathepsin B Inhibitor With Increased Lysosome Uptake and Light-activated Biological Functions

Chemistry Second Award

Cathepsin B in lysosome is a cysteine protease that plays an important role in various pathological processes including many cancers. Therefore, it is a cancer protein biomarker. A method to…

Development of Novel Biodegradable Bioplastics Using Mango Peels Intended for Packaging Film

Chemistry

Implementation of biodegradable, eco-friendly, sustainable bioplastic films derived from fruit peels not only solves the issue of greenhouse gases emitted by disposed fruit waste in landfill…

Does Temperature Affect the Dissolved Oxygen Concentration Within Hydroponic Solutions?

Chemistry

Hydroponics, in which the plant environment is controlled and managed, has been found to be effective in increasing food production. This is extremely important to meet the needs of future p…

Drawing a Picture in a Liquid! Novel Photochromic System Using Methylene Blue Reduction With Ascorbic Acid

Chemistry

I developed a novel photochromic system using methylene blue with ascorbic acid and investigated the optimal photochromic conditions. The photochromic solution is environmentally friendly an…

Drug Delivery of Nitric Oxide (NO) in Relation to Diabetes Mellitus

Chemistry

Approximately 37.3 million Americans suffer from Type Two Diabetes Mellitus (T2DM), a disorder in which the body fails to regulate sugar levels. In T2DM, insulin resistance reduces the avail…

Dyes Adsorption Using Activated Carbon From Coffee Capsule Grounds

Chemistry

Brazil is a world leader in coffee production and is the second-largest consumer. As a result, over 1,000,000 t of coffee grounds accumulate in landfills yearly and decompose, releasing gree…

Effect of Temperature on Oxidation speeds

Chemistry Third Award

Effects of Dietary Supplements on Simulated Arterial Plaque

Biochemistry

Atherosclerosis causes millions of deaths worldwide and no known medications dissolve the plaques that build up inside arteries. Some proponents of alternative medicine claim that B-complex…