ISEF · 2022
Improving Rice Nutrition
Chemistry
Milled rice is deficient in almost all major classes of nutrients except carbohydrates. Poor nutrition of rice has resulted in severe malnutrition problems in developing countries where the…
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ISEF · 2022
Improving the Ductility and Overall Usability of Casein Plastic Through the Addition of a Plasticizer
Chemistry
Most plastics are made of polyethylene terephthalate, a polymer that is nearly indestructible, taking centuries to decompose. To be more environmentally-friendly, there are substitutes avail…
ISEF · 2022
Innovation of "Copper to Silver to Gold - The Alchemist's Dream" Using Aluminum Foil and Anionic Surfactant
Chemistry
An experiment in which a copper plate is zinc-plated and then heated to brass plating is known as the "Alchemist's Dream." With the conventional method, there is a risk of bumping and scatte…
ISEF · 2022
In silico Analysis of Small Molecules With Possible SARS-CoV-2 RNA-Dependent RNA Polymerase Inhibiting Properties and Their Therapeutic Potential
Biochemistry
Since an effective and reliable antiviral drug against COVID-19 (caused by the SARS-CoV-2 virus) has not been developed, research on novel therapeutic targets is crucial. The RdRp protein of…
ISEF · 2022
Investigating the Binding Interactions of Small-Molecule Inhibitors to PLKs Using Molecular Dynamics Simulations
Chemistry
Protein kinases are important anticancer drug targets due to their crucial role in regulating key biochemical and cellular processes. Polo-like kinase 1 (PLK-1) is a key regulatory marker fo…
ISEF · 2022
Investigating the Therapeutic Potential of Epigallocatechin Gallate and Theaflavin-3, 3'-digallate on Inhibiting ACE2-Spike Protein Binding and Mitigating Induced-Cellular Death by SARS-CoV-2
Biochemistry Fourth Award
As of April 2022, there have been 500 million cases and 6.18 million deaths from COVID-19 worldwide. Current treatments are limited, thus necessitating the development of an effective therap…
ISEF · 2022
Investigation Into the Feasibility of Maclura pomifera as a Commercial Source of Pectin
Biochemistry
The current pectin industry is built around the utilization of orange peels (citrus sinensis) as the most commercially viable option for pectin harvesting. Current estimates of pectin conten…
ISEF · 2022
Isolation, Extraction, and Identification of Fluorescent Unknown in Friedel-Crafts Acylation of Biphenyl
Chemistry
Acylation of biphenyl with acetyl chloride is a commonly used Friedel-Crafts reaction. Side products observed between the reactant and the acetylating agent are often due to incorrect stoich…
ISEF · 2022
Lactate! Lactate! Lactate!
Biochemistry
Dairy farmers get paid on components such as protein and fat in the milk. Therefore, knowing what stage in a cow's lactation they will produce milk with the highest percent of components can…
ISEF · 2022
LuxI/LuxR-Type Quorum Sensing System in K61, Dickeya Species Novel: Growth and AHL Production in MgSO4-Rich Brine
Biochemistry
Quorum sensing (QS) is a density-dependent mechanism of gene regulation and bacterial communication, allowing bacterial communities to benefit from cooperative group behavior and is commonly…
ISEF · 2022
Microbial Desalination Cells (MDCs) for Sea Water Desalination, Simultaneous Wastewater Treatment, and Electricity Production
Biochemistry
The emerging global water crisis is significant. Urban congestion is mushrooming at an alarming rate and has increased by 41 percent since the early 1990s. Consequently, with agriculture bei…
ISEF · 2022
Mobile Carbon Capture - Phase 3
Chemistry Fourth Award
A mobile carbon capture device to extract CO2 from car exhaust was designed and built to fit in a normal passenger car, a Toyota Sports Utility Vehicle (SUV). The mobile device was construct…
ISEF · 2022
Modification of Silica Surface With Supercritical Water as a Tool Indicating New Possibilities of Existing Separation Methods
Chemistry Second Award
Silica capillaries have been an integral part of the instrumentation used in many areas of analytical chemistry for decades, especially in analytical separations. In most cases, they are use…
ISEF · 2022
Natural Termite Control: A Novel Biomolecular Approach
Biochemistry
Termite infestations pose a threat to infrastructure and crops throughout the world. Many current termiticides contain toxic carbamates, organophosphates, pyrethroids, and chlorinated hydroc…
ISEF · 2022
New Cultivation Technology of Plants at Hydroponic System with Applying Inductors (Phytohormones)
Biochemistry
Purpose: Project aim: study the effect of salicylic acid-SA (0,1 mM), indole-3-butyric acid-IBA (350mg/plant) on the yield time of Phaseolus vulgaris, determination the activity of the main…
ISEF · 2022
Novel Biodegradable Fluorescent Polymers for Anti-Counterfeiting Applications
Chemistry
According to recent reports, the global economic losses caused by product counterfeiting reached 1.82 trillion USD in 2020. One of the newest and promising methods for anti-counterfeiting is…
ISEF · 2022
Novel Inhibitors for Conserved Regions of RecA To Slow Bacterial Antibiotic Resistance
Biochemistry Third Award
Drug-resistant infections are expected to cause 10 million deaths annually by 2050. The increased prevalence of resistant bacteria has resulted in a scarcity of therapeutic alternatives, mak…
ISEF · 2022
Novel Plant-Derived Scaffolds Influence Cellular Mechanotransduction and Differentiation
Biochemistry First Award
There is a significant global need for tissue engineering scaffolds that are comparable to human tissue. Interestingly, the plant kingdom presents a striking similarity to human tissues, esp…
ISEF · 2022
Novel Protein Quantification With Metal-Organic Framework (MOF)-Coated Quartz Crystal Microbalance (QCM)
Chemistry
Interaction of Oligohistidine-tags(His-tag) with metal ions have long have been known and used for various purposes such as protein purification. Here, we conducted quantification of his-tag…
ISEF · 2022
Novel Synthesis and Characterization of Manganese Nanoparticles: A Third Year Study
Chemistry Third Award
Nanoparticles are of significance because of their small size and unique characteristics. Few studies have been conducted on the synthesis of manganese nanoparticles. This project was among…
ISEF · 2022
Phase VII: Inhibiting Cancer Metastasis by Using EGCG To Target the 67 kDa Laminin Receptor
Biochemistry
Cancer is one of the most prominent diseases plaguing the world today, and causes thousands of deaths daily. The 67 Kilodalton Laminin Receptor protein (67 LR protein), whose primary functio…
ISEF · 2022
Phytochemical Research of Peganum harmala
Chemistry
Peganum hermala l. is a medicinally important herb of the family Zygophyllaceae. Peganum hermala l. is a perennial herbaceous, glabrous plant growing in the arid and semiarid regions, steppe…
ISEF · 2022
Polyethyleneimine Impregnated Adsorbents for a Community-Based Carbon Capture and Sequestration Approach
Chemistry First Award
Traditional Carbon Capture and Storage uses a combination of technologies to capture, transport, and store carbon dioxide (CO2) from large point sources such as coal or natural gas-fired pow…
ISEF · 2022
Pulverizing PFOA: Analyzing Molecular Dynamics Simulations Between Perfluorooctanoic Acid and a Fluoroacetate Dehalogenase Enzyme
Chemistry Fourth Award
Perfluorooctanoic acid (PFOA) has been connected to changes in liver function, immunity issues, thyroid disease, and kidney and testicular cancer. Due to these effects, PFOA is banned for us…
ISEF · 2022
Pyrocystis fusiformis vs. the Circadian Rhythm: How Does Light Exposure Affect the Bioluminescence of Pyrocystis fusiformis?
Biochemistry
This experiment was performed to see if the bioluminescence of Pyrocystis fusiformis would diminish over time after being exposed to a circadian rhythm that does not include both light and d…
ISEF · 2022
Rearrangements of N-Aryl Hydroxamic Acid Methanesulfonates: Towards Novel and Valuable Organic Substances
Chemistry
N-Aryl hydroxamic acids (NAHAs) represent a group of valuable synthetic intermediates. Their N OH modification, by appending good leaving group (LG), triggers intramolecular rearrangement le…
ISEF · 2022
Reducing the Toxicity of Heavy Metals
Chemistry
Water is indispensable for survival. But, it gets polluted by industrial effluents, domestic effluents etc. Due to water pollution, the world is facing acute scarcity of fresh water. Usage o…
ISEF · 2022
Research on the Microscopic Mechanism of CO2 Capture Using TBAB Semi-Clathrate Hydrate Formation
Chemistry
Purpose of my research (1) Use a new additive to form semi-clathrate hydrate at lower pressures and higher temperatures for CO2 capture. (Research question) (2) Can Tetra-n-butyl Ammonium Br…
ISEF · 2022
Reversible Inhibition of Retinoic Acid Synthesizing Enzyme ALDH1A2 With WIN18,446 Derivatives in Male Contraception
Biochemistry
Almost half of the pregnancies around the globe are unplanned. The associated risks related to unexpected pregnancy include both physical and mental stress. A wide range of contraceptive met…
ISEF · 2022
Scientific Web Tool for the Analysis and Visualization of the Packing of Biological Macromolecules
Biochemistry Fourth Award
This Project entails the development of a web tool for the analysis of biological macromolecules, most notably proteins and RNA molecules, and the subsequent visualization of the results. Th…