ISEF · 2017
Combo Infusion
Biomedical Engineering
Many Hospitalized patients receive multiple drugs intravenously using an Infusion system, as part of their treatment. In such cases, any interaction between the various drugs must be prevent…
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ISEF · 2017
Design for an Alternate Wireless Medical Auscultation Device
Biomedical Engineering
Stethoscope are the most widely used medical technology in the world, used in both developed and developing nations. A normal acoustic stethoscope can cost anywhere between $40 and $1,000 an…
ISEF · 2017
Designing Oral Implants to Dissipate Occlusal Load
Biomedical Engineering
Almost 5 million dental implants are placed annually in the United States, and they are now considered the standard of care for the replacement of lost teeth. Despite their increased use for…
ISEF · 2017
Detecting the Elusive Lyme Disease: Creating a Novel Lateral Flow Test for Detection of Borrelia burgdorferi in Ticks
Biomedical Engineering Fourth Award
Lyme disease is the most common tick-borne illness affecting nearly 300,000 people each year. The debilitating symptoms are largely unspecific save for a bulls-eye rash that only appears in…
ISEF · 2017
Developing a Cost Effective 3D Printed Hand with Speech Recognition
Biomedical Engineering
Statement of the Problem: Children‘s prosthetic needs are complex due to their constant growth and psychosocial development. Existing technologies for customized computer-assisted prosthetic…
ISEF · 2017
Development of 3D-printed Electronic Stethoscope and Open-Source Android-Based Platform with Automated Diagnosis of Cardiac Conditions
Biomedical Engineering
Three quarters of cardiovascular disease (CVD) associated deaths occur in resource-poor medical regions. The conventional stethoscope remains the primary tool used to diagnose CVD in these s…
ISEF · 2017
Development of a Low Cost Multi-Analyte Microfluidic Device
Biomedical Engineering
Access to health care in low income communities and developing countries is limited. The purpose of this project was to develop a prototype of a string-based microfluidic device to detect an…
ISEF · 2017
Development of a Novel 3D Printed 2-Stage Hollow Fiber Filter to Reduce Pain on Injection of a Propofol Emulsion
Biomedical Engineering
Propofol is the most common anesthetic agent used in the United States, but 60% of the time patients feel pain on injection (Jalota et al. 2011). This pain is hypothesized to be from the fre…
ISEF · 2017
Diagnosing the Puzzle of Autism: A Wearable Micro-Movement Sensing Cap for Early Pediatric Screening
Biomedical Engineering Third Award
Autism spectrum disorder (ASD) is the name for a group of developmental disorders. ASD includes a range of symptoms, skills, and levels of disability. According to the Centers for Disease Co…
ISEF · 2017
Diagnosing Tumours Using fNIR Imaging System
Biomedical Engineering
Free-space broadband functional near infrared (fNIR) spectroscopy technique has been used to clinically measure the optical properties of ganglion cysts and lipomas tumors. The fNIR system m…
ISEF · 2017
Dilatant Insole to Reduce Damage Inflicted by Peripheral Neuropathy
Biomedical Engineering
Peripheral neuropathy afflicts 20 million United States citizens and leads to sensory loss in the extremities as well as infection, injury, and amputation. Daily ambulation alone can cause d…
ISEF · 2017
Efficient Genome Editing of Mammalian Cells via Novel sgRNA Architectures and Cas9 Endonuclease
Biomedical Engineering
10,000 of all known human diseases are monogenic, caused by a single mutation in the DNA. Scientists have tried developing the Zinc Finger Nuclease (ZFN) and Transcription Activator-like Eff…
ISEF · 2017
Engineering a Device to Improve Vision via Photoactivation
Biomedical Engineering
Goal: To build a practical device capable of improving my vision by directing a controlled level of light into the eye (i.e. photoactivation.) Problem/Background: I have multiple eye conditi…
ISEF · 2017
Engineering and Evaluation of 3D Printed Polymer Scaffolds for Bone Tissue Regeneration
Biomedical Engineering
The regeneration of bone defects caused by trauma, fracture, and disease is a significant clinical challenge for both military and civilian patients in the United States and around the world…
ISEF · 2017
Engineering Surface Chemistries to Improve Tissue-Material Integration in Medical Implants
Biomedical Engineering
Tissue-material integration is a key challenge of engineering medical implants and implantable biosensors. Implants often undergo an intense foreign body reaction orchestrated by human macro…
ISEF · 2017
Flexible Low-Cost Sensory Patch for Chronic Wheezing Detection
Biomedical Engineering
Chronic lung diseases are a serious world threat. According to the World Health Organization, there are approximately 364 million pulmonary disease patients around the world and this number…
ISEF · 2017
Formulation of a Bovine Gelatin Crosslinked Scaffold for Potential Human Tissue Applications: Cost-Effective, Patient Specific Alternative Treatment of Acetabular Labral Tears of the Hip
Biomedical Engineering Third Award
Acetabular labral tears comprise 22% of reported groin pain. Repairs involve suturing torn tissue to the bone via anchors, or removing inflamed tissue. Both prevent the body from healing nat…
ISEF · 2017
Hermes Braindeck: A Brain-Computer Interface for Communication with Patients Initially Classified as Comatose or Vegetative
Biomedical Engineering Second Award
The Glasgow Coma Scale was proposed in the 1970s to classify the level of awareness of patients who have suffered some sort of traumatic brain injury (TBI). This scale is still used in hospi…
ISEF · 2017
High-Dimensional Single-Cell Cytometry Analysis for Understanding Cancer Stemness
Biomedical Engineering Fourth Award
While cancer starts as a single cell, termed cancer stem cell (CSC), the progeny CSCs are not created equal, but exhibit a spectrum of phenotypes of varying renewal capacities, metastatic po…
ISEF · 2017
Identifying Bacteria with "Fingerprints" Based on Laser Diffraction Patterns
Biomedical Engineering
The prevailing identification and diagnosis of bacteria species requires the shipment of temperature-sensitive biological samples to a microbiology laboratory for biochemical, genetic or imm…
ISEF · 2017
Identifying Limiting Nutrient on Stem Cell Spheroid Viability for Human Cardiac Tissue Regeneration
Biomedical Engineering
Objective: Stem cell-derived cardiomyocyte spheroids show enormous potential as cell delivery systems that improve cell retention and engraftment. Their survival post-transplantation in isch…
ISEF · 2017
Improved Detection of Cardiac Troponin I with Reduced Antibodies
Biomedical Engineering
Cardiac Troponin I (cTnI) has been the ideal biomarker for myocardial infarction diagnosis in the past decade. In our experiment, we presented a new method for increasing the sensitivity of…
ISEF · 2017
Inexpensive and Accurate Test Kit for Zika: Point-of-Care Diagnostics in 10 Minutes with Paper-Based Serological Flow Device
Biomedical Engineering
The recent Zika outbreak in over 48 countries has severe socioeconomic impact due to its damage to fetal brain development. Currently, Zika virus (ZIKV) is diagnosed with polymerase chain re…
ISEF · 2017
Inexpensive Glucose Monitoring Device for Diabetics Using Capillary Action of Crosslinked Sensing Fluid, Year II
Biomedical Engineering Second Award
Diabetes currently affects over 346 million people worldwide and is one of the leading causes of death. Current treatment requires frequent blood-glucose tests followed by necessary insulin…
ISEF · 2017
Investigating Tuned Magneto-Rheological Reservoirs, Compression Systems, and Shear Thickening Fluids to Improve Mean Peak Acceleration as Measured by High-G Accelerometers in Hockey Headgear
Biomedical Engineering
The prevention of concussion and sub concussive injury in helmeted activities are of great military, commercial, legal, and medical interest. A Summation of Tests for the Analysis of concuss…
ISEF · 2017
Investigation of a Novel Saccade-Based Diagnostic for Rapid Concussion Detection
Biomedical Engineering
In the United States, athletes suffer roughly 3.8 million concussions per year. Unfortunately, many current concussion diagnostics are subjective, placing athletes in potentially dangerous s…
ISEF · 2017
Isolating Motion Patterns in Compromised Human Gait as Proxy for Amputees Wearing Prosthetics
Biomedical Engineering
Quantitative measurement of human gait is currently prohibitively expensive in the field of orthotics and prosthetics. This project is investigating the capabilities of a relatively inexpens…
ISEF · 2017
Manipulating Matter on the Nanoscale: Incorporated Branched Junction Inside a DNA Tensegrity Triangle
Biomedical Engineering
DNA-sequenced engineering of protein nucleants may reduce limitations associated with protein crystallization and structure determination for structure-based drug development. This project i…
ISEF · 2017
Mechanized Collection of Organic Spider Silk
Biomedical Engineering
Spider silk is a very valuable but elusive material. It is 30 times tougher than steel yet is difficult to obtain. Synthetic production has had limited success because the chemical changes t…
ISEF · 2017
Membrane-Based Nanostructured Biosensor to Detect Hemolytic Bacteria
Biomedical Engineering Second Award
Early detection of bacterial pathogens is increasingly important in health care. Currently, the most common method to detect hemolytic bacteria in blood is culture testing. This method is ti…