Browse real student projects, abstracts, and awards.
ISEF · 2024
Cellular and Molecular Biology
Leukodystrophies, rare genetic disorders that cause abnormal myelin development or destruction, have recently been discovered to be associated with the polr3a gene. This experiment aimed to…
ISEF · 2024
Cellular and Molecular Biology Fourth Award
Alzheimer’s Disease (AD) affects tens of millions of people around the world as the most prevalent form of dementia. A hallmark of AD is the intracellular and extracellular aggregation of th…
ISEF · 2024
Cellular and Molecular Biology
MicroRNAs (miRNA) are an emerging class of non-coding RNA that enable post-transcriptional regulation through repression and degradation of target mRNA. Dysregulation of miRNAs has been asso…
ISEF · 2024
Cellular and Molecular Biology
Methylation marks are a type of epigenetic mark established during cellular differentiation that change with time and are often associated with aging and degenerative diseases. Thus, manipul…
ISEF · 2024
Cellular and Molecular Biology Second Award
Age-related metabolic disorders often result from the dysfunction in adipose tissue, which is responsible for energy storage and mobilization. Formation of the adipose tissue or adipogenesis…
ISEF · 2024
Cellular and Molecular Biology
Targeted peptide cancer therapies which are less toxic compared to synthetic chemotherapies,is a research field of growing interest.Cell surface receptors Integrin-avß3(avß3),which recognize…
ISEF · 2024
Cellular and Molecular Biology
Natural killer (NK) cells are involved in surveillance and killing of tumor cells. Although classically part of innate immunity, I and others have identified a subset of NK cells with adapti…
ISEF · 2024
Cellular and Molecular Biology Third Award
Peripheral T-cell lymphoma (PTCL) is a rare and aggressive non-Hodgkin lymphoma resulting from clonal proliferation of mature post-thymic T-cells. The mechanisms behind PTCL development and…
ISEF · 2024
Cellular and Molecular Biology First Award
In a recent study, 33% of individuals with neurodevelopmental disorders (NDDs) carried mutations in ASXL3, whose function is unknown. To understand ASXL3’s role in NDDs, we used CRISPR techn…
ISEF · 2024
Cellular and Molecular Biology
Retinoblastoma (Rb) is a form of rapidly developing retinal cancer, and like many cancers, metastasizes via the release of lipid-encased extracellular vesicles (EVs) which create desirable c…
ISEF · 2024
Cellular and Molecular Biology
Glioblastoma is the most aggressive primary brain tumor, with an average survival of 14.6 months even with treatment. Prior research has shown that a protein, PTPµ, is cleaved in tumor tissu…
ISEF · 2024
Cellular and Molecular Biology
Lysophosphatidic acid (LPA) is a bioactive lipid which can bind to six LPA receptors (LPA1-6) on the cell membrane and regulate various cell activities. Previous studies have shown that LPA1…
ISEF · 2024
Cellular and Molecular Biology
Hypoxia Inducible Factor 1 Alpha (Hif1a) contributes to cancer growth in most solid tumors. Because normal cells do not generally require HIF1, it is a potential target. How cancer will adap…
ISEF · 2024
Cellular and Molecular Biology
Natural Killer (NK) cells are an essential component of innate host defense against Hepatocellular Carcinoma (HCC). A central determinant of NK cell function is their tissue residency. I hyp…
ISEF · 2024
Cellular and Molecular Biology
In living organisms, DNA is a critical macromolecule; its stability and integrity are vital for the normal functioning of cellular processes, such as DNA replication and DNA repair. Sunlight…
ISEF · 2024
Cellular and Molecular Biology
Yes-associated protein 1 (YAP1) is a transcriptional coactivator known for driving oncogenesis. YAP1 is able to revive the gene expression of transcription factor FOS following the downregul…
ISEF · 2024
Cellular and Molecular Biology
Prion proteins are associated with neurodegenerative diseases, causing normal cellular proteins to fold abnormally in a rapidly progressive manner. Studying the genes required for yeast prio…
ISEF · 2024
Cellular and Molecular Biology Fourth Award
A high incidence of hepatorenal impairment in cancer patients treated with cisplatin has been reported. Berberine, a plant alkaloid possesses wide range of medicinal properties. Mitochondria…
ISEF · 2024
Cellular and Molecular Biology Third Award
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is an extremely rare neurological small vessel disease, affecting about 2-5 people every…
ISEF · 2024
Cellular and Molecular Biology
With a mortality rate of 98%, primary amebic meningoencephalitis (PAM) is a rare and deadly infection caused by Naegleria fowleri. Many scientists believe with climate change and rising temp…
ISEF · 2024
Cellular and Molecular Biology
TAS2R38 gene encodes a bitter taste receptor protein that influences the perception of bitter compounds such as phenylthiocarbamide PTC. Specific polymorphisms within TAS2R38 have been linke…
ISEF · 2024
Cellular and Molecular Biology
Over $10.8 billion is spent yearly on oncology trials. Yet, a mere 3.4% of them succeed due to a lack of precision in target selection. Precise selection of targets could significantly impro…
ISEF · 2024
Cellular and Molecular Biology Second Award
The adoptive transfer of tumor antigen-specific T cells (ASTs) can serve as an effective immunotherapy against pediatric solid tumors of the central nervous system (CNS). However, current me…
ISEF · 2024
Cellular and Molecular Biology
Amyotrophic lateral sclerosis (ALS) is a disease that is largely a mystery within the medical community due to the unpredictable nature of its pathogenesis in sporadic ALS and its lack of a…
ISEF · 2024
Cellular and Molecular Biology Fourth Award
Cells enter the senescence state when aging occurs, an irreversible cell cycle arrest. This exhibits an age-related increase in the levels of Senescence Associated Secretory Phenotype (SASP)…
ISEF · 2024
Cellular and Molecular Biology
The Endoplasmic Reticulum (ER) is crucial for cell health, facilitating functions like protein and lipid synthesis, calcium storage, and stress response. Previously, research has established…
ISEF · 2024
Cellular and Molecular Biology
Each year, twenty million people are diagnosed with cancer. Its prevalence is increasing at a faster pace than any other disease. Cyclin-Dependent Kinase 2 (CDK2) plays a key role in regulat…
ISEF · 2024
Cellular and Molecular Biology
A sharp rise in food allergies during the last century has left millions with this chronic, often life-threatening condition. In fact, nearly all known autoimmune diseases are being diagnose…
ISEF · 2024
Cellular and Molecular Biology Fourth Award
Strongyloides, a group of parasites identified in ruminants, had displayed a growing resistance against commercial anthelmintic treatments which has caused economic losses in livestock and a…
ISEF · 2024
Cellular and Molecular Biology
Solute carriers (SLCs) are key to cellular transport of growth substances and their dysfunction is often associated with disease. Studies have focused on the solute carrier protein Slc22a17,…