Browse real student projects, abstracts, and awards.
ISEF · 2023
Cellular and Molecular Biology Fourth Award
Organoids are a 3D stem cell model which recapitulate the physiology of human organs and are derived from induced pluripotent stem cells (iPSCs). The purpose of this project was to optimize…
ISEF · 2023
Cellular and Molecular Biology
More than seventy conditions are attributed to oxidative stress, including neurodegenerative diseases, cancer, and chronic pathological processes. The exposure of DNA demethylation by the in…
ISEF · 2023
Cellular and Molecular Biology
Cancer cells develop resistance to chemotherapy by rewiring their metabolism. In Year-1 of our project, we showed that melphalan-resistant multiple myeloma (MM) cells had higher amounts of m…
ISEF · 2023
Cellular and Molecular Biology
Alzheimer’s Disease (AD) is a disease that causes extreme memory loss in people and can severely affect their day-to-day life. AB is a molecule that accumulates in the brains of AD patients…
ISEF · 2023
Cellular and Molecular Biology
Birth defect screenings are traditionally performed on live animals, exposing pregnant mothers to harmful toxicants. However, this method is ethically problematic and requires the sacrifice…
ISEF · 2023
Cellular and Molecular Biology
Abdominal aortic aneurysms (AAAs) are a life-threatening condition with a ruptured mortality of 80-90% with no current drug-based therapies. They result from the thinning of media & adventit…
ISEF · 2023
Cellular and Molecular Biology
I designed an experiment testing if fluorescent-dyed silica nanoparticles could be used to identify leukemia biomarkers under UV imaging. I hypothesized that if fluorescent-dyed silica nanop…
ISEF · 2023
Cellular and Molecular Biology
As the prevalence of obesity and other chronic diseases continue to increase, so do the cases of hepatocellular carcinoma (HCC). Despite the development of new treatments, HCC remains diffic…
ISEF · 2023
Cellular and Molecular Biology
Histone binding proteins regulate histone metabolism and play important roles in multiple biological processes that are linked to human diseases. Here we developed an in-silico approach to s…
ISEF · 2023
Cellular and Molecular Biology Fourth Award
Methylglyoxal (MGO) is a ubiquitous metabolite produced as a byproduct of glycolysis that spontaneously glycates protein residues to form advanced-glycation end products (AGEs), called fruct…
ISEF · 2023
Cellular and Molecular Biology
The HIV virus caused millions of deaths in the last decades. Today's treatment for HIV infection has substantial shortcomings. Genetic engineering of B cells by inserting a gene encoding ant…
ISEF · 2023
Cellular and Molecular Biology
While significant advances in neuroscience have been achieved in understanding, diagnosing, and treating neurological diseases, still much remains to be characterized. The purpose of this st…
ISEF · 2023
Cellular and Molecular Biology
Hypoxia (reduced oxygen) is common in many brain tumors, including gliomas. Hypoxia Inducible Factor 1 Alpha (Hif-1a) is upregulated and stabilized under hypoxic conditions, leading to tumor…
ISEF · 2023
Cellular and Molecular Biology
Despite decades of research, scientists have yet to understand the molecular mechanisms behind aging. Currently, scientists have utilized the thoroughly annotated genomes of model organisms…
ISEF · 2023
Cellular and Molecular Biology
Epstein-Barr Virus (EBV), commonly known as the cause of infectious mononucleosis, infects approximately 95% of the adult human population worldwide (Bjornevik et al., 2022). Recently, EBV i…
ISEF · 2023
Cellular and Molecular Biology
Oral cavity squamous cell carcinoma (OCSCC) is an aggressive and life-changing disease affecting ~55,000 patients in the United States yearly. Treatment of this cancer involves radical surge…
ISEF · 2023
Cellular and Molecular Biology
Lysine methyltransferases (KMTs) are an essential group of enzymes that regulate gene expression. In an attempt to track rising cancer cases, scientists discovered a detrimental mutation of…
ISEF · 2023
Cellular and Molecular Biology
Melanoma cancer is a deadly disease that hundreds of thousands of people are diagnosed with each year and has little treatment success using current methods. One potential method is the tran…
ISEF · 2023
Cellular and Molecular Biology
The evolutionarily conserved DOT1 family of proteins is essential for development in higher mammals. However, overactive DOT1L acts as an oncoprotein, most notably in childhood leukemia. Alt…
ISEF · 2023
Cellular and Molecular Biology
Standard approaches for cancer treatment involves surgery, chemotherapy and radiation. Although these approaches have resulted in prolongation of the survival window, it is also accompanied…
ISEF · 2023
Cellular and Molecular Biology
Breast cancer is the most prevalent cancer in women worldwide. Of the breast cancer subtypes, triple negative breast cancer (ER-, PR-, HER2-) has the worst prognosis due to the lack of effec…
ISEF · 2023
Cellular and Molecular Biology
Alginate beads are used to encapsulate cells in allogeneic transplants to avoid rejection from the patient’s immune system. The permeability of these beads plays a crucial role in the surviv…
ISEF · 2023
Cellular and Molecular Biology
Cancer is one of the deadliest diseases around the globe. It has been shown that more than 50% of cancer cases have an overexpression of the MYC oncogene. The main challenge in these cancers…
ISEF · 2023
Cellular and Molecular Biology
RNA has numerous roles in cells and its information is encoded by its sequence, secondary structure and chemical modifications. The least explored RNA modifications are noncanonical 5' RNA c…
ISEF · 2023
Cellular and Molecular Biology
Idiopathic Pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic lung disease with high morbidity and mortality with limited treatments currently available. A key feature of IPF is ai…
ISEF · 2023
Cellular and Molecular Biology
Alzheimer's disease is demarcated as a progressive neurodegenerative disorder resulting from the irrational number of people affected worldwide (Ecuadorian Journal of Neurology, s.f.). To st…
ISEF · 2023
Cellular and Molecular Biology
The Keap1Nrf2 Pathway, responds to oxidative by signaling to the MHS1 complex to activate CD8 and CD4 T-cells via APCs. CD4 and CD8 T-cells function in conjunction to fight invading pathogen…
ISEF · 2023
Cellular and Molecular Biology First Award
Mitochondria are highly dynamic organelles that interact with various cellular components, including the endoplasmic reticulum (ER). This essential interaction occurs through mitochondria-as…
ISEF · 2023
Cellular and Molecular Biology
Bone implants have a risk factor of 57.1% for infection, mostly caused by Staphylococcus aureus. These can transform into a deadly bone infection called osteomyelitis. Hospitals spend $17,00…
ISEF · 2023
Cellular and Molecular Biology
Beta Carotene is an important organic compound with a bright orange color naturally produced in plants. It is hailed for its health benefits and antioxidant properties. In a previous study,…