Browse real student projects, abstracts, and awards.
ISEF · 2022
Cellular and Molecular Biology Fourth Award
Glioblastoma Multiforme (GBM) is a type of malignant brain tumor and it is the most lethal with a median survival of only 21 months. It is characterized by an extremely strong recurrence rat…
ISEF · 2022
Cellular and Molecular Biology
Staphylococcus aureus bacteria is the world’s leading cause of bone implant infection causing osteomyelitis. Osteomyelitis accounts for half of all chronic diseases in people over 50 and thi…
ISEF · 2022
Cellular and Molecular Biology Third Award
Autophagy is a “self-eating” cellular pathway. It is a core molecular mechanism for cellular and organismal homeostasis and is also a pro-longevity mechanism. Autophagy dysfunction links the…
ISEF · 2022
Cellular and Molecular Biology
Spinal Cord Injuries (SCI) are prevalent in society, EphA4 is a gene that inhibits axon regeneration following development and is known to decrease neural plasticity during rehabilitation. R…
ISEF · 2022
Cellular and Molecular Biology
As the prevalence of obesity and other chronic diseases continue to increase, so do the cases of hepatocellular carcinoma (HCC). Despite the development of new treatments, HCC remains diffic…
ISEF · 2022
Cellular and Molecular Biology
The APOE3 allele, the most common APOE variant, is believed to influence Alzheimer’s Disease (AD) progression. It has been proposed that the TOMM40 gene – which neighbors APOE3 -- might serv…
ISEF · 2022
Cellular and Molecular Biology First Award
Obesity is the enlargement of adipose tissue caused by consuming more calories than used by the body. Excessive fat accumulation in the adipose tissue forms adipocyte hypertrophy, which prom…
ISEF · 2022
Cellular and Molecular Biology
Cancer immunotherapies such as checkpoint inhibitors and CAR-T therapies are becoming a therapeutic option for cancer patients with advanced and metastatic disease. However, clinical success…
ISEF · 2022
Cellular and Molecular Biology
Cardiovascular Disease (CVD) is the leading cause of death globally. Thrombosis is the most common underlying pathology of CVD. Thrombin, an enzyme responsible for converting fibrinogen to f…
ISEF · 2022
Cellular and Molecular Biology
Cytotoxic T cells (CTLs) are lymphocytes capable of recognizing and attacking cancer cells. During continuous attacks, CTLs undergo an exhaustion process, gradually losing their abilities un…
ISEF · 2022
Cellular and Molecular Biology
This study is a proof-of-concept to validate if CRISPR a/i (activation/interference) system can modulate LMNA gene expression in lung cancer cells. To establish the CRISPRa/i system, I used…
ISEF · 2022
Cellular and Molecular Biology
Actin-based molecular motor myosin Va (myoVa) is a biological machine involved in intracellular cargo transport, which is essential for normal cellular function. Although a single myoVa is s…
ISEF · 2022
Cellular and Molecular Biology
Ovarian Cancer is the deadliest cancer among all of the gynecological malignancies, largely due to chemoresistance. Carboplatin is a widely accepted Platinum-based chemotherapy agent used fo…
ISEF · 2022
Cellular and Molecular Biology
Lead nanoparticles (PbNPs) in industrial areas pose a potential risk to organisms, therefore it is necessary to study the effects of their chronic inhalation. This project aimed to analyze t…
ISEF · 2022
Cellular and Molecular Biology
Abstract: Mammary adenocarcinoma is the most common malignant tumor in women, and the liver is one of the sites with a high incidence of metastasis. Previous studies have shown that the micr…
ISEF · 2022
Cellular and Molecular Biology Fourth Award
The touch-sensible plants of the Mimosa genus are a factory of phytochemicals that could prolongate lifespan and treat autoimmune diseases such as diabetes. While its phytochemical flavonoid…
ISEF · 2022
Cellular and Molecular Biology
The prevalence of skin melanoma in humans has shown a substantial yearly increase, leading to skin melanoma comprising of almost all skin cancer deaths. The NKG2DL protein, an essential prot…
ISEF · 2022
Cellular and Molecular Biology Fourth Award
Colorectal cancer is the second most common cause of cancer death in the US, but it is curable and preventable if diagnosed early. Following the recent emphasis on the human microbiome's imp…
ISEF · 2022
Cellular and Molecular Biology
Cushing's disease (CD) is an endocrine disorder characterized by increased levels of cortisol and caused by an Adrenocorticotropin hormone (ACTH)-secreting pituitary corticotroph adenoma. Th…
ISEF · 2022
Cellular and Molecular Biology
Cellular proliferation and differentiation are fundamentally regulated by the physical landscape of the chromatin. In the intestine, a highly regulated molecular process maintains homeostasi…
ISEF · 2022
Cellular and Molecular Biology
Knee osteoarthritis (OA) is a degenerative joint disease in which the cartilage within the joint gradually wears away, leading to pain, stiffness, and swelling of the knee. About 10% of men…
ISEF · 2022
Cellular and Molecular Biology
Inflammatory Bowel Disease (IBD) is an autoimmune disease that develops in humans resulting from inflammation of the gastrointestinal tract. This is due to an overabundance of myeloid cells…
ISEF · 2022
Cellular and Molecular Biology Second Award
A growing area of research is focused on identifying drugs that have differential cytotoxic effects on normal and cancer cells. Pomegranate polyphenols are potent antioxidants and has antica…
ISEF · 2022
Cellular and Molecular Biology
Diabetes is a growing and deadly epidemic around the world and particularly in the United States. Complications associated with diabetes arise from prolonged high blood glucose concentration…
ISEF · 2022
Cellular and Molecular Biology Third Award
Neuroblastoma (NB) is the most common extracranial cancer diagnosed in children, accounting for 6% of all pediatric cancer cases and 15% of childhood cancer deaths. The disproportionate NB m…
ISEF · 2022
Cellular and Molecular Biology
GenX, a fluorinated chemical, has been discovered in multiple drinking water supplies around the world. However, studies have found that GenX exhibits high cytotoxicity towards different hum…
ISEF · 2022
Cellular and Molecular Biology
SARS-CoV-2 non-structural protein 12 (Nsp12) is a viral polymerase and a key drug target. The in vitro production of pure Nsp12 protein is crucial for advancing drug and treatment strategies…
ISEF · 2022
Cellular and Molecular Biology
The SARS-CoV-2 virus, responsible for the COVID-19 pandemic, has resulted in millions of deaths. Rare immune cells are minor cell types with reduced frequency, and their function in COVID-19…
ISEF · 2022
Cellular and Molecular Biology
Duchenne muscular dystrophy (DMD) is a progressive disabling neuromuscular disorder caused by recessive X-linked mutations in the dystrophin protein and affects 1 in every 3,500 live male bi…
ISEF · 2022
Cellular and Molecular Biology
Long-term trends for leukemia (blood cancer) have consistently shown that men have significantly higher incidence and mortality rates than women, but the reason why this occurs isn’t clear.…