Browse real student projects, abstracts, and awards.
ISEF · 2021
Cellular and Molecular Biology
The ability to precisely measure cell permeability will be a necessary asset in the future development of intracellular antibiotics. The efficacy of the antibiotic vancomycin is reliant on c…
ISEF · 2021
Cellular and Molecular Biology
The transforming growth factor beta (TGFB) superfamily consists of a group of regulatory proteins that bind to membrane receptors and generate an intracellular signal to regulate cellular pr…
ISEF · 2021
Cellular and Molecular Biology
The purpose of this project is to see if Atrazine passes its negative effect on the sensory, motor, and learning behaviors of planaria to the second generation planaria. The second generatio…
ISEF · 2021
Cellular and Molecular Biology
Oxidative stress produces macromolecular damage. It is implicated in several disease states such as cancer, aging and neurodegenerative disorders. Therefore, it is necessary to find solution…
ISEF · 2021
Cellular and Molecular Biology Fourth Award
Adeno-associated virus (AAV) 9 and its variants are promising vectors for gene therapy to treat neurological diseases. The clinical uses of AAV9 along with its variants are leveraged by the…
ISEF · 2021
Cellular and Molecular Biology
Amyloid-beta (Aß) and insulin, two substrates of insulin-degrading enzyme (IDE), are critically important in the pathogenesis of Alzheimer's disease (AD) and type 2 diabetes (T2D), respectiv…
ISEF · 2021
Cellular and Molecular Biology
A big question in the neuroscience community pertaining to our sense of smell is how the olfactory cortex is able to distinguish between millions of odors. I hypothesized that chemical compo…
ISEF · 2021
Cellular and Molecular Biology
The genome of cells is like an instruction book, telling cells what to do and how to do it. A behavior embedded in the genome of cancer cells known as “tumor self-seeding” (the tendency for…
ISEF · 2021
Cellular and Molecular Biology Second Award
Common genetic diseases—systemic diseases caused by thousands of mutations—affect millions of people around the world. Many of these mutations fall within regulatory regions. While the mutat…
ISEF · 2021
Cellular and Molecular Biology
Over one million individuals in the United States are addicted to cocaine, yet limited knowledge of underlying molecular mechanisms prevents effective treatment development. Chronic cocaine…
ISEF · 2021
Cellular and Molecular Biology Fourth Award
The bacterium Pseudomonas aeruginosa causes many human and plant diseases, infecting over 50,000 people annually. ~75% of Pseudomonas proteins are characterized; however, pathogenic mechanis…
ISEF · 2021
Cellular and Molecular Biology
My project is an assay of the involvement of HYPE (huntingtin yeast-interacting partner E) in the translocation of BiP (binding immunoglobulin protein) to the cell surface. BiP is the master…
ISEF · 2021
Cellular and Molecular Biology
Cancer cells are formed when mitosis, the asexual reproduction of cells, becomes uncontrollable and cells can no longer send or receive signals concerning their own growth. The purpose of th…
ISEF · 2021
Cellular and Molecular Biology
Biofuels currently are produced through the fermentation of agricultural products. However, due to the growing issue of world hunger an alternative biofuel material was research. With refere…
ISEF · 2021
Cellular and Molecular Biology
Fibroblast growth factors (FGFs) influence growth, migration and survival of cells as well as cell division in mammary gland development. FGF signaling deregulation can thus cause formation…
ISEF · 2021
Cellular and Molecular Biology Fourth Award
T-cells are a class of lymphocytes that play an essential role in adaptive immunity and are known to develop in the thymus. However, functional T-cells are also found in animals lacking a th…
ISEF · 2021
Cellular and Molecular Biology
Prochlorococcus is a cyanobacterium that produces 20% of Earth’s oxygen. This organism is a key organism for balancing global CO2 levels. However, anthropogenic CO2 production exceeds the ab…
ISEF · 2021
Cellular and Molecular Biology
Lung adenocarcinoma (LUAD) accounts for forty percent of all lung cancer cases in the United States. Treatment currently focuses on surgery and chemotherapy but survival rates remain lower t…
ISEF · 2021
Cellular and Molecular Biology Third Award
Down syndrome (DS) is the most common genetic disorder in humans. It is known that trisomy of chromosome 21 causes DS, but how this chromosomal gain produces the complex DS phenotype, includ…
ISEF · 2021
Cellular and Molecular Biology Fourth Award
Non-small cell lung carcinoma (NSCLC), accounting for the majority of lung cancer cases, has become a high-studied topic in the field of immunotherapeutics. While there are treatment options…
ISEF · 2021
Cellular and Molecular Biology
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder for which there is no cure. In 97% of sporadic ALS patients, TDP-43 forms insoluble protein aggregates dysregulating RNA m…
ISEF · 2021
Cellular and Molecular Biology
Carcass bruising from horns costs the cattle industry $10 million a year (Anderson, 2012). It is vital to develop safe and cost effective advancements in dehorning procedures. Removal of hor…
ISEF · 2021
Cellular and Molecular Biology
Hepatitis C virus (HCV) annually infects 2-3% of the world’s population. The infection causes numerous liver complications, but there is currently no vaccine against HCV. Even the antiviral…
ISEF · 2021
Cellular and Molecular Biology
The leukocyte human interferon alpha-2b is widely used for curing viral infection diseases and some types of cancer. Nowadays, the recombinant interferon is commonly produced in bacterial an…
ISEF · 2021
Cellular and Molecular Biology
Recent approaches in cancer immunotherapy revolve around encapsulating immunostimulatory molecules within nanoparticles and using systemic delivery to deliver them into the tumor, generating…
ISEF · 2021
Cellular and Molecular Biology Second Award
The CRISPR Cas9 Ribonucleoprotein (RNP) complex is well known for its precise gene editing abilities. Catalytically dead Cas9 (dCas9) also has diverse applications, including base editing, C…
ISEF · 2021
Cellular and Molecular Biology
Using Saccharomyces cerevisiae (baker's yeast) as a model organism, this research aims to study the Hog1 pathway in yeast and consequently mammalian homologous p38, which are SAPKs in contro…
ISEF · 2021
Cellular and Molecular Biology Third Award
Intragenomic conflict occurs when selfish genes attempt to increase their own prospects of replication at the expense of the organism. It has clinical and ecological significance–the genes a…
ISEF · 2021
Cellular and Molecular Biology
Parkinson’s disease (PD) is the second most common neurodegenerative disorder, affecting more than 6 million patients globally. Though previous studies have proposed several disease-related…
ISEF · 2021
Cellular and Molecular Biology
Small cell lung cancer (SCLC) is the most aggressive form of cancer with a 5-year survival rate of <7%. SCLC’s high mortality rate is attributed to early metastasis and treatment resistance.…