Browse real student projects, abstracts, and awards.
ISEF · 2018
Cellular and Molecular Biology Third Award
Migraines are the third most prevalent illness in the world, and migraine symptoms (e.g. severe pain, visual disturbances, nausea, and cognitive impairments) all impede daily life. At the ne…
ISEF · 2018
Cellular and Molecular Biology Fourth Award
While recent advances in gene therapy have reinforced the appeal for using Adeno-Associated Virus (AAV) for targeted gene delivery, the small genome delivery size limits the capabilities of…
ISEF · 2018
Cellular and Molecular Biology Fourth Award
The field of genetic engineering is rapidly developing with exciting new discoveries being made every day. However, existing gene editing technologies do not have perfect accuracy, and creat…
ISEF · 2018
Cellular and Molecular Biology Third Award
ABSTRACT Bumble bee (Bombus spp.) populations are declining nationally as well as globally due to a variety of factors including habitat loss, pathogens, and immune deficiencies. Because of…
ISEF · 2018
Cellular and Molecular Biology
Huntington’s disease(HD) is a fatal neurodegenerative disorder which affects around 1 in every 10,000 people. This autosomal dominant genetic disorder is caused by an expansion of the polygl…
ISEF · 2018
Cellular and Molecular Biology Second Award
Great advancements have been made in using adeno-associated virus (AAV) vectors for gene therapy; however, the basic biology behind AAV capsid assembly remains poorly characterized. Discover…
ISEF · 2018
Cellular and Molecular Biology
The VPS-34 gene in C. elegans is required for vesicular trafficking, including endocytosis, though the exact function of the protein is still unknown. My project involves identifying the spe…
ISEF · 2018
Cellular and Molecular Biology
In-vitro fertilization has been linked with a small but statistically significantly increased risk of mental retardation. With a such rapidly expanding field, that slight increased risk resu…
ISEF · 2018
Cellular and Molecular Biology
Drosophila Schneider 2 (S2) cells are commonly cryopreserved for long-term storage for use in biological and pharmaceutical product research. While fetal bovine serum (FBS) allows for higher…
ISEF · 2018
Cellular and Molecular Biology
The purpose of this study was to analyze the dietary patterns of Sea Lion predation on Salmonids. Salmon species are protected under the Endangered Species Act and Sea Lions are protected un…
ISEF · 2018
Cellular and Molecular Biology
Optogenetics is technique that uses light to regulate biological processes in living cells. It is based on genetically engineered proteins that are activated by light. Due to high spatial-te…
ISEF · 2018
Cellular and Molecular Biology
Purpose: Vessels, lined by endothelial cells (ECs), supply oxygen (O2) to our bodies. When tissues are devoid of enough O2, Hypoxia Inducible Factor (HIF) is stimulated to induce >200 genes…
ISEF · 2018
Cellular and Molecular Biology First Award
Though cell cycle regulation plays a key role in numerous developmental processes, including morphogenesis and differentiation, the regulatory systems that control the cell cycle remain poor…
ISEF · 2018
Cellular and Molecular Biology
This research broadens the understanding of the murine immune system in inflammatory bowel disease simulations, highlighting the presence of a newly classified cell group, Myeloid Derived Su…
ISEF · 2018
Cellular and Molecular Biology
The dynamic organization of the human genome is largely dependent on the nucleosome occupancy. Changes in nucleosome distribution allow access to the underlying DNA, and nucleosomes have bee…
ISEF · 2018
Cellular and Molecular Biology
The use of the electronic nicotine delivery system, also known as electronic cigarette (e-cig), is tremendously rising in young adults in the US. E-cigs are the most commonly used tobacco-re…
ISEF · 2018
Cellular and Molecular Biology
PDE inhibitors are frequently used as pharmaceuticals to treat conditions such as pulmonary diseases and erectile dysfunction via the cAMP dependent signaling pathway. However, PDE inhibitor…
ISEF · 2018
Cellular and Molecular Biology
In recent studies, scientists found that cancer is highly associated with inflammation and, macrophages, which play an important role in inflammatory response, is found to be interfered by t…
ISEF · 2018
Cellular and Molecular Biology
Low birth weight (LBW) offspring have a high risk of developing cardiovascular and renal diseases such as chronic kidney disease and hypertension, which have no preventative measures or cure…
ISEF · 2018
Cellular and Molecular Biology
Environmental exposures can impact the expression of genes via epigenome, which is transgenerationally inherited. Short term exposure to unfavorable conditions could permanently alter the ex…
ISEF · 2018
Cellular and Molecular Biology
Background Breast cancer, the most common cancer in women results in 40,000 deaths annually. Different breast cancer subsets are defined based on the expression of specific receptors: estrog…
ISEF · 2018
Cellular and Molecular Biology
In neurodegenerative diseases such Parkinson’s disease (PD), the misfolding and deposition of proteins a-synuclein and tau is hallmark. Conformational changes in native unfolded proteins, ta…
ISEF · 2018
Cellular and Molecular Biology
Malignant melanoma is characterized by its ability to metastasize, and is responsible for 90% of skin cancer mortality. Metastasis requires cell migration from a primary tumor to blood and l…
ISEF · 2018
Cellular and Molecular Biology
Oxidative damage in the genome occurs when reactive oxygen species (ROS), a byproduct of metabolism or from exogenous sources, come in contact with DNA. This has been suggested to play a rol…
ISEF · 2018
Cellular and Molecular Biology
Gliomas are primary malignant tumors of brain and spinal cord with low survival without effective therapies. Annexin A1 (ANXA1) is a protein, which participates in proliferation, immune resp…
ISEF · 2018
Cellular and Molecular Biology
The overuse of antimicrobials in many aspects of daily life has ushered in a wave of antimicrobial resistance to antibiotics that have been effective for decades. Resistance to antibiotics i…
ISEF · 2018
Cellular and Molecular Biology
Nearly one in eight deliveries in the United States is preterm. Preterm birth has been correlated with oxidative stress, damage caused to cells by free radicals, in the uterine myometrium. O…
ISEF · 2018
Cellular and Molecular Biology
The objective of this project was to characterize gal-7 as an antibiotic. The purpose of this research was to identify a model for glycan-specific antibiotics capable of reducing the risk of…
ISEF · 2018
Cellular and Molecular Biology
Irreparable DNA lesions caused by radiation therapy induce apoptosis, a suicidal response that occurs in both cancerous and normal cells. Remarkably, mouse and human tissues in experiments t…
ISEF · 2018
Cellular and Molecular Biology Third Award
At first glance, diabetic kidney disease and cancer may seem to have little in common besides sharing high mortality rates. Diabetic kidney disease is a condition in which increased glucose…