Browse real student projects, abstracts, and awards.
ISEF · 2017
Cellular and Molecular Biology
Parkinson’s disease (PD) is an incurable, progressive neurodegenerative disorder characterized by the intracellular accumulation of alpha-synuclein (aSyn). aSyn oligomers have been implicate…
ISEF · 2017
Cellular and Molecular Biology
Mucociliary clearance of toxins from the respiratory tract epithelium depends on a precise ratio of ciliated to goblet cells. If this ratio is low, mucus produced by the goblet cells builds…
ISEF · 2017
Cellular and Molecular Biology
In vitro fertilization (IVF) involves a complex series of clinical and laboratory procedures with the goal of conceiving a healthy child for infertile couples. The high frequency of chromoso…
ISEF · 2017
Cellular and Molecular Biology Fourth Award
Migraines are the third most prevalent illness, affecting one billion people worldwide. Migraine symptoms may include a severe throbbing headache, disturbed vision, nausea, and sensitivity t…
ISEF · 2017
Cellular and Molecular Biology
Cancer is one of a vast collection of diseases that kills millions of people each year across the world. Normally helping to prevent cancer, tumor suppressor genes like Antigen NY-CO-13 (p53…
ISEF · 2017
Cellular and Molecular Biology Second Award
Cardiometabolic disease (CMD) is a cluster of correlated diseases. Risk of heart disease, the world’s leading cause of death, is greatly increased by metabolic syndrome, a combination of dia…
ISEF · 2017
Cellular and Molecular Biology
The fast adaptation of auditory hair cells is a well preserved process in mammals that rapidly adjusts the sensitivity of the auditory receptors to stimulus. Although diversely implicated in…
ISEF · 2017
Cellular and Molecular Biology Third Award
It is estimated that 1 in 6 children in the United States are affected by a developmental disability. These afflictions include Autism, Intellectual disability, and developmental delay, all…
ISEF · 2017
Cellular and Molecular Biology
The aim of this project was to discover whether or not oxidative stress could cause DNA damage in cells deficient of Ogg1 and if so, to see if that would increase transcriptional mutagenesis…
ISEF · 2017
Cellular and Molecular Biology Second Award
RNAi-based modalities offer sequence-specific knockdown of tumor survival and growth, presenting a novel alternative to ineffective conventional treatments. This study investigated a pH sens…
ISEF · 2017
Cellular and Molecular Biology
Cancer develops when cells cannot activate apoptosis (“programmed cell death”) in response to damaging perturbations. Noxa, the focus of this project, plays a vital role in promoting apoptos…
ISEF · 2017
Cellular and Molecular Biology
The purpose of this research was to determine if a new non-intrusive allergy test can detect dust and dander allergens in IgE sensitized individuals using a capillary tube precipitation test…
ISEF · 2017
Cellular and Molecular Biology
Embryonic stem cells (ESCs) are a promising cell source for regenerative medicine because of their unlimited proliferation capacity and ability to differentiate into any cell type. However,…
ISEF · 2017
Cellular and Molecular Biology
Some crops have been genetically modified to obtain desired traits; such as pesticide-producing or drought resistant. There has been a debate on whether Genetically Modified Organisms (GMOs)…
ISEF · 2017
Cellular and Molecular Biology
Altered epigenetic landscapes play an integral role in the deregulation of genes. In diffuse large B-cell lymphoma (DLBCL), tumor cells overexpress BCL6, a transcription factor that normally…
ISEF · 2017
Cellular and Molecular Biology
Lyme disease, the most prevalent tick-borne illness in the United States, is transmitted through the bite of ticks carrying the bacterium, Borrelia burgdorferi (B. b.). Current serological d…
ISEF · 2017
Cellular and Molecular Biology
Pluripotent stem cells have a great potential to proliferate in the lab and differentiate into all cell types. Pancreatic progenitor cells generated from PSCs can be transplanted directly in…
ISEF · 2017
Cellular and Molecular Biology
FACT is a complex of 2 subunits: SSRP1 and SPT16. Both subunits are required to be present and associated with each other through their dimerization domain (DD) in order for FACT functionali…
ISEF · 2017
Cellular and Molecular Biology
Antioxidants are known to play an important role in the protection of cells. Laboratory experiments using C-Fern spore cells were conducted to investigate the effect of antioxidants on spore…
ISEF · 2017
Cellular and Molecular Biology
Using ultraviolet radiation (UV), this project demonstrates genetic mutations in the DNA of the Drosophila Melanogaster. According to my hypothesis, if Drosophila Melanogaster are exposed to…
ISEF · 2017
Cellular and Molecular Biology Fourth Award
An effective “catch-all” cure for cancer remains elusive, but one promising target that could be used in such a cure is telomerase because it enables replicative immortality, has near ubiqui…
ISEF · 2017
Cellular and Molecular Biology
The RE-1 Silencing Transcription Factor (REST) is a central transcriptional repressor that regulates a wide range of neural genes. REST is highly conserved among vertebrates and modulates pr…
ISEF · 2017
Cellular and Molecular Biology Third Award
The practice of smoking hookah, a traditional smoking apparatus that uses charcoal to indirectly heat shisha tobacco, as a possible alternative to cigarettes is an emerging trend of global s…
ISEF · 2017
Cellular and Molecular Biology
The overall objective of this research is to define the viral proteins composed in the exosomes and demonstrate that flavivirus proteins are present in the exosomes. The ongoing epidemic cau…
ISEF · 2017
Cellular and Molecular Biology
Neurodegenerative diseases are the deadliest in the world. Neurodegeneration is the progressive loss of the function of neurons. This study analyzes the relationship between the PITX3 gene a…
ISEF · 2017
Cellular and Molecular Biology
Poor lifestyle choices can lead to excess free radicals that shorten telomeres, the end caps of chromosomes. Telomere shortening is linked to cellular senescence and premature aging. This ex…
ISEF · 2017
Cellular and Molecular Biology Fourth Award
The purpose of this project was to characterize human galectin-4 and its anti-microbial properties against self-like antigen bearing gram-positive and gram-negative bacteria while identifyin…
ISEF · 2017
Cellular and Molecular Biology
The post-transcriptional regulation controls RNA gene expression. This occurs between the process of transcription and translation of the gene. For this, it’s important to know the structure…
ISEF · 2017
Cellular and Molecular Biology Fourth Award
The T-box transcription factor TBX3 is highly expressed within the lung endothelium, yet the effect of its expression is unknown. This study aimed to overcome present limitations by determin…
ISEF · 2017
Cellular and Molecular Biology
Substance (tobacco, alcohol) use and various inflammatory diseases (periodontitis, oral lichen planus, leukoplakia) induce chronic inflammation, which is a mechanism for head and neck squamo…