38,465 real projects from ISEF, the Canada-Wide Science Fair, JSHS, AJAS, the Calgary Youth Science Fair and the California Science & Engineering Fair — searchable by meaning, and filterable by fair, year, category and award.
ISEF · 2024
Cellular and Molecular Biology
200 million of the human population is affected by infertility—a disease that can develop in both men and women due to various reasons—which causes a decrease in the individuals reproductive…
ISEF · 2024
Cellular and Molecular Biology
Pancreatic Ductal Adenocarcinoma (PDAC) is a common type of pancreatic cancer and is characterized by a extremely high mortality rate. PDAC tumors tend to be extremely stiff, the reason for…
ISEF · 2024
Cellular and Molecular Biology
In recent decades CRISPR/Cas9 has emerged as a promising cancer treatment. Using CRISPR knockout plasmid to target the CDK11 cell proliferation gene within cancerous cells could force said c…
ISEF · 2024
Cellular and Molecular Biology
Immunotherapy involves exposing patients to small amounts of the allergen to desensitize their immune systems. This can be dangerous to patients who experience anaphylactic reactions to the…
ISEF · 2024
Cellular and Molecular Biology
Metals and their transporters influence cell behavior in cancer, and previous research demonstrated that manganese promotes malignancy. Therefore, if metal transporters are essential in main…
ISEF · 2024
Cellular and Molecular Biology
Despite increasing cancer incidence globally, few alternative treatments to chemotherapy and radiation exist. These standard therapies require specialized equipment, are costly, and have ser…
ISEF · 2024
Cellular and Molecular Biology Second Award
Selenoprotein O (SelO) is a mitochondrial pseudokinase enzyme that AMPylates, or transfers an AMP molecule to, cellular proteins. However, SelO’s role as an AMPylator in oxidative stress res…
ISEF · 2024
Cellular and Molecular Biology Third Award
Breast cancer, annually affecting over 2.3 million people worldwide, is targeted in this study through the epichaperome, a network of proteins including heat shock protein 90 (HSP90). PUH71,…
ISEF · 2024
Cellular and Molecular Biology
Hepatocellular carcinoma (HCC) is the most prominent type of liver cancer around the world, and it ranks as the fourth leading cause of cancer death worldwide with these rates only rising. D…
ISEF · 2024
Cellular and Molecular Biology
The intestines are a crucial part of the digestive system, aiding in digestion and nutrient absorption. They feature a columnar barrier of intestinal epithelial cells, called the intestinal…
ISEF · 2024
Cellular and Molecular Biology Third Award
Fibrodysplasia Ossificans Progressiva(FOP) is an extremely rare and debilitating bone disorder that affects 0.00005% of the population. The defining characteristic of FOP is severe heterotop…
ISEF · 2024
Cellular and Molecular Biology
Humanity is always looking for the next fix, and because of this we have created and used many different substances. In this study nicotine, vaporizer liquids, and CBD oils were tested to se…
ISEF · 2024
Cellular and Molecular Biology
Alzheimer’s disease (AD) is the leading cause of dementia, accounting for 60-80% of cases in the United States. Failed interventions, aimed at the symptoms of the disease, have created a dri…
ISEF · 2024
Cellular and Molecular Biology Fourth Award
The p53 gene is a tumor suppressor in the human body that is mutated in 50-60% of human cancers. p53 acts to suppress retrotransposons (jumping genes) within the genome which are prevalent i…
ISEF · 2024
Cellular and Molecular Biology
Gastric adenocarcinoma is the fourth most common cancer in Brazil. . Symptoms appear at a more advanced stage of the disease, weight loss, anorexia, dysphagia, epigastric pain, melena and ea…
ISEF · 2024
Cellular and Molecular Biology
Cancer is a worldwide problem, especially breast cancer in women, with the treatment options consisting primarily of chemotherapy. It is not only very expensive but it is known to target fas…
ISEF · 2023
Cellular and Molecular Biology Fourth Award
Organoids are a 3D stem cell model which recapitulate the physiology of human organs and are derived from induced pluripotent stem cells (iPSCs). The purpose of this project was to optimize…
ISEF · 2023
Cellular and Molecular Biology
More than seventy conditions are attributed to oxidative stress, including neurodegenerative diseases, cancer, and chronic pathological processes. The exposure of DNA demethylation by the in…
ISEF · 2023
Cellular and Molecular Biology
Cancer cells develop resistance to chemotherapy by rewiring their metabolism. In Year-1 of our project, we showed that melphalan-resistant multiple myeloma (MM) cells had higher amounts of m…
ISEF · 2023
Cellular and Molecular Biology
Alzheimer’s Disease (AD) is a disease that causes extreme memory loss in people and can severely affect their day-to-day life. AB is a molecule that accumulates in the brains of AD patients…
ISEF · 2023
Cellular and Molecular Biology
Birth defect screenings are traditionally performed on live animals, exposing pregnant mothers to harmful toxicants. However, this method is ethically problematic and requires the sacrifice…
ISEF · 2023
Cellular and Molecular Biology
Abdominal aortic aneurysms (AAAs) are a life-threatening condition with a ruptured mortality of 80-90% with no current drug-based therapies. They result from the thinning of media & adventit…
ISEF · 2023
Cellular and Molecular Biology
I designed an experiment testing if fluorescent-dyed silica nanoparticles could be used to identify leukemia biomarkers under UV imaging. I hypothesized that if fluorescent-dyed silica nanop…
ISEF · 2023
Cellular and Molecular Biology
As the prevalence of obesity and other chronic diseases continue to increase, so do the cases of hepatocellular carcinoma (HCC). Despite the development of new treatments, HCC remains diffic…
ISEF · 2023
Cellular and Molecular Biology
Histone binding proteins regulate histone metabolism and play important roles in multiple biological processes that are linked to human diseases. Here we developed an in-silico approach to s…
ISEF · 2023
Cellular and Molecular Biology Fourth Award
Methylglyoxal (MGO) is a ubiquitous metabolite produced as a byproduct of glycolysis that spontaneously glycates protein residues to form advanced-glycation end products (AGEs), called fruct…
ISEF · 2023
Cellular and Molecular Biology
The HIV virus caused millions of deaths in the last decades. Today's treatment for HIV infection has substantial shortcomings. Genetic engineering of B cells by inserting a gene encoding ant…
ISEF · 2023
Cellular and Molecular Biology
While significant advances in neuroscience have been achieved in understanding, diagnosing, and treating neurological diseases, still much remains to be characterized. The purpose of this st…
ISEF · 2023
Cellular and Molecular Biology
Hypoxia (reduced oxygen) is common in many brain tumors, including gliomas. Hypoxia Inducible Factor 1 Alpha (Hif-1a) is upregulated and stabilized under hypoxic conditions, leading to tumor…
ISEF · 2023
Cellular and Molecular Biology
Despite decades of research, scientists have yet to understand the molecular mechanisms behind aging. Currently, scientists have utilized the thoroughly annotated genomes of model organisms…