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ISEF · 2025
Cellular and Molecular Biology
Apoptosis is a key mechanism in many cancer therapies and can be induced through the interaction of death receptors with specific ligands. Among these, TNF-alpha and TRAIL are widely studied…
ISEF · 2025
Cellular and Molecular Biology
Alzheimer's disease (AD) pathogenesis follows a pattern of selective vulnerability, defined by varying levels of neurodegeneration across brain regions and neuronal populations. While the me…
ISEF · 2025
Cellular and Molecular Biology
Finding a treatment for breast cancer has been a persisting need as one in eight women will experience this disease in her lifetime. Current treatment options present harmful side effects an…
ISEF · 2025
Cellular and Molecular Biology
Manganese is a central promoter of malignancy in cancer. In the previous project, it was observed that Mn alters gene expression of metal transporters, favoring the accumulation of this elem…
ISEF · 2025
Cellular and Molecular Biology
The purpose of this experiment was to design a cell model using a rat pheochromocytoma (PC12) cell to simulate Diabetic Peripheral Neuropathy (DPN). It was proposed that the higher the level…
ISEF · 2025
Cellular and Molecular Biology
Approximately 5.9% of the global population—over 300 million people—suffer from rare genetic disorders, many of which require AAV-based gene therapy. AAV-B3, an ancestrally derived serotype…
ISEF · 2025
Cellular and Molecular Biology
Skeletal muscle cells regulate and provide many bodily functions. Skeletal muscle cells support movement, posture, and temperature regulation. In addition, skeletal muscle triggers an immune…
ISEF · 2025
Cellular and Molecular Biology
Hypoxia is common in solid tumors. Hypoxia Inducible Factor 1 Alpha (Hif1a) is upregulated and stabilized under hypoxic conditions, leading to tumor growth. This experiment targets Hif1a bec…
ISEF · 2025
Cellular and Molecular Biology
In 2022, 2.3 million cases of breast cancer were diagnosed worldwide, with approximately 17% classified as triple-negative breast cancer (TNBC). TNBC is challenging to treat due to the absen…
ISEF · 2025
Cellular and Molecular Biology
Toxic methylmercury (MeHg) readily crosses the blood brain and placental barriers, leading to developmental delays and neurological issues particularly with in utero exposure. Upon exposure,…
ISEF · 2025
Cellular and Molecular Biology
Mismatch repair (MMR) deficiency in DNA is an ongoing problem as a factor behind DNA mutations and various cancers, including colorectal cancer and gliomas. Understanding how to strengthen D…
ISEF · 2025
Cellular and Molecular Biology
Chromosomal rearrangements caused by mobile transposons (TEs) are implicated in human cancers and neurological disorders. The Ac element of the Ac(Activator)/Ds(Dissociation) TE system, foun…
ISEF · 2025
Cellular and Molecular Biology
Neurogenesis during early embryonic development is a highly regulated, transcriptional process that establishes the framework for the vertebrate central nervous system (CNS). The QSER1 gene…
ISEF · 2025
Cellular and Molecular Biology
In vitro drug sensitivity testing is critical for identifying effective cancer treatments. However, due to the vast number of potential drug monotherapies and combination therapies, in vitro…
ISEF · 2025
Cellular and Molecular Biology
Central nervous system (CNS) diseases such as Alzheimer's, epilepsy, and stroke affect over 1 billion people globally, and dysregulated astrocytic calcium signaling can drive these pathologi…
ISEF · 2025
Cellular and Molecular Biology
Introduction: Pancreatic ductal adenocarcinoma (PDA) remains one of the deadliest malignancies due to late diagnosis, extensive metastasis, and limited treatment options. A multifunctional g…
ISEF · 2025
Cellular and Molecular Biology
Alzheimer’s disease (AD), a neurodegenerative disorder causing cognitive deterioration, remains a leading cause of death. Previous research has not fully clarified the impact of amyloid-beta…
ISEF · 2025
Cellular and Molecular Biology
Environmental changes, including rising atmospheric carbon dioxide levels and increasing ozone pollution, continue to alter Earth's atmosphere. Ozone layer depletion leads to increased level…
ISEF · 2025
Cellular and Molecular Biology
Perfluorooctanesulfonic Acid (PFOS) and Perfluorooctanoic Acid (PFOA), known as “forever chemicals,” are persistent environmental pollutants associated with many diseases, including cancer.…
ISEF · 2025
Cellular and Molecular Biology
Breast cancer is a leading cause of cancer-related deaths among women, with over 2.3 million new cases diagnosed worldwide each year. Obese breast adipocytes secrete pro-inflammatory cytokin…