38,465 real projects from ISEF, the Canada-Wide Science Fair, JSHS, AJAS, the Calgary Youth Science Fair and the California Science & Engineering Fair — searchable by meaning, and filterable by fair, year, category and award.
ISEF · 2020
Cellular and Molecular Biology
Honeybee keepers are experiencing increased mortalities, many of which have been attributed to Colony Collapse Disorder (CCD). CCD is theorized to occur after a hive has become susceptible t…
ISEF · 2020
Cellular and Molecular Biology
Glial cells provide structure and metabolic support for neurons. Glioblastomas (GBM) are malignant tumors of glial cells. To improve their survival, cancerous cells have elevated levels of p…
ISEF · 2020
Cellular and Molecular Biology
Cancer is the second leading cause of death in the United States and prevention by pinpointing and eliminating its causes is the most important part of combating any disease, even more than…
ISEF · 2020
Cellular and Molecular Biology
Myelodysplastic syndrome (MDS) is a group of cancers in which stem cells in the bone marrow have a clonal advantage and cause irregular maturation of blood cells. Dysplastic cells cannot mig…
ISEF · 2020
Cellular and Molecular Biology
The Yes-associated protein (YAP) is a transcriptional regulator that has been linked to various cellular processes such as tissue regeneration and metabolism. Typically, the Hippo pathway re…
ISEF · 2020
Cellular and Molecular Biology
Breast cancer is characterized by an aggressive, malignant tumor that can metastasize to distant places of the body. Research stems from treatment with palbociclib, an innovative drug, again…
ISEF · 2020
Cellular and Molecular Biology
Lung cancer is the second most prominent type of cancer and accounts for the most cancer-related deaths each year. Small cell lung cancer, a major subtype of lung cancer, has a 5-year surviv…
ISEF · 2020
Cellular and Molecular Biology
The purpose of this project is to transform E. coli with the gene alkB2 from the marine bacteria A. borkumensis; to generate a strain of E. coli that can degrade oil in terrestrial environme…
ISEF · 2020
Cellular and Molecular Biology
All living organisms are spontaneously emitting ultra-weak photons in basic metabolism and cellular respiration. This photon emission which occurs in living organisms is known as biophoton e…
ISEF · 2020
Cellular and Molecular Biology
Neurodegeneration afflicts ~9 million, costs $800 billion/year in the US, and is one of the greatest unmet medical needs of the 21st century. Amyotrophic lateral sclerosis (ALS) is a devasta…
ISEF · 2020
Cellular and Molecular Biology
Traditional views of embryonic development hold that germ layer differentiation begins and ends with gastrulation. However, recent evidence suggests mesoderm and ectoderm induction occurs po…
ISEF · 2020
Cellular and Molecular Biology
Despite studies linking a high fat diet to colorectal cancer incidence, little is known regarding intestinal adaptation to a high fat diet. As intestinal regeneration is regulated by Canonic…
ISEF · 2020
Cellular and Molecular Biology
Hypertonic Dextrose (HD) has been clinically suggested to regenerate cartilage, yet the underlying cellular mechanisms are not well understood. The single published in vitro study, which emp…
ISEF · 2020
Cellular and Molecular Biology
Carcinomas are cancers originating in epithelial cells that cover the lining of internal organs or the external skin, and whose study remains significantly relevant in today’s field of medic…
ISEF · 2020
Cellular and Molecular Biology
The Apolipoprotein E (APOE) gene is the most influential genetic risk factor for Alzheimer’s Disease (AD). In addition to genotype, the implication of gender must also be investigated; women…
ISEF · 2020
Cellular and Molecular Biology
Almost one million people in the world will be diagnosed with a genetic kidney disease occurring in the collagen IV within the glomerular basement membrane (GBM). I wanted a less-complex viv…
ISEF · 2020
Cellular and Molecular Biology
Background: Alzheimer’s disease (AD) is one of the most debilitating neurological diseases leading to impairments in cognitive, sensory, and motor functions. Amyloid Aß plaques and neurofibr…
ISEF · 2020
Cellular and Molecular Biology
Current cancer therapies face significant challenges, such as inducing adverse patient side effects, having limited access to solid tissue tumours, or failing to target metastatic tumours. A…
ISEF · 2020
Cellular and Molecular Biology
How cells regulate and maintain their size is fundamentally unknown. Failure to maintain a consistent cell size has been associated with cardiac disease, brain disease, musculoskeletal disea…
ISEF · 2020
Cellular and Molecular Biology
Hypertension, a detriment linked to various risk factors, contributes to the development of renal and diabetic damage, increasing the risk for the development of cardiovascular disease, whic…
ISEF · 2020
Cellular and Molecular Biology
Schwannomatosis is a rare genetic disease characterized by pain and the development of peripheral nerve sheath tumors called schwannomas. Schwannoma in patients have mutations in the NF2 gen…
ISEF · 2020
Cellular and Molecular Biology
Acute Respiratory Distress Syndrome (ARDS) is a dangerous lung disease that reduces oxygen to the essential organs of the body. The treatment that patients with ARDS receive is a combination…
ISEF · 2020
Cellular and Molecular Biology
Adeno-associated viruses (AAV) are popular vectors for human gene therapy, yet their more efficacious use clinically is limited by an incomplete understanding of its virion assembly. More re…
ISEF · 2020
Cellular and Molecular Biology
Advances in artificial insemination techniques and semen handling have led to an increased rate of successful pregnancies and increased efficiency in large scale breeding programs. These tec…
ISEF · 2020
Cellular and Molecular Biology
Amyotrophic Lateral Sclerosis (ALS) is a devastating, neurodegenerative, adult-onset disorder, for which there is no known cure. In approximately 97% of sporadic ALS patients, a protein call…
ISEF · 2020
Cellular and Molecular Biology
To combat the rise in heart disease and resulting heart attacks, researchers have been looking into the use of stem cells as a possible treatment for these major medical issues. Following my…
ISEF · 2020
Cellular and Molecular Biology
The daf-2 and daf-16 genes have been highlighted for their reciprocal activity in altering longevity in the model organism Caenorhabditis elegans. Both daf-2 and daf-16 present orthologs in…
ISEF · 2019
Cellular and Molecular Biology
Norepinephrine (NE) and acetylcholine (ACh) mediate cell-to-cell communication in the central and peripheral nervous systems. Due to their importance in regulating many complex brain functio…
ISEF · 2019
Cellular and Molecular Biology Fourth Award
Aggregation of protein tau into neurofibrillary tangles and a-synuclein into Lewy bodies are hallmarks of Alzheimer’s and Parkinson’s disease, respectively. These proteins are known to form…
CSEF · 2019
Biochemistry/ Molecular Biology First Award
Objectives My project aims to synthesize small molecules that prevent the HLA-DQ2 receptor from binding to alpha-2-gliadin proteins found in gluten, thus preventing the autoimmune response a…