Browse real student projects, abstracts, and awards.
ISEF · 2019
Cellular and Molecular Biology
Head and neck squamous cell carcinomas (HNSCC) are aggressive tumors with high recurrence rates and poor patient survival. Although HNSCCs only account for 3% of cancers in the United States…
ISEF · 2019
Cellular and Molecular Biology
Purpose: GBM (glioblastoma multiforme), a primary brain tumor, exhibits more invasive and malignant behavior when developed proximal to the subventricular zone (SVZ) of the brain. A unique f…
ISEF · 2019
Cellular and Molecular Biology
The ribosomal production of the nucleoli of cells control metabolism (rate of protein production) as an organism ages. This experiment was designed to show the relationship between the age o…
ISEF · 2019
Cellular and Molecular Biology
Currently, there is no cure for Type 1 Diabetes; however, a potential lead in the field of Juvenile Diabetes research is the Bio-Artificial Pancreas. This system essentially encapsulates mat…
ISEF · 2019
Cellular and Molecular Biology
UVB radiation has been known to cause skin cancer by destroying cellular structures and creating mutations in DNA. UVB radiation (from sun) causes repeated cell DNA damage and destroys life…
ISEF · 2019
Cellular and Molecular Biology
While chemotherapy and targeted therapy are common cancer treatments, both have limitations. Induced apoptosis is an attractive alternative. Mitochondrial apoptosis is controlled by the BCL-…
ISEF · 2019
Cellular and Molecular Biology
Ixodes scapularis (black-legged ticks) infected with Borrelia burgdorferi, the causative agent of Lyme disease, is endemic throughout the upper Midwest. Over the most recent years, the numbe…
ISEF · 2019
Cellular and Molecular Biology
Huntington’s disease (HD) is a fatal neurodegenerative disorder which affects around 1 in every 10,000 people. This autosomal dominant genetic disorder is caused by an expansion of the polyg…
ISEF · 2019
Cellular and Molecular Biology
Nicotinic acetylcholine receptors, or nAChRs, form the basis of nicotine addiction. The ALPHA4BETA2ALPHA5 nAChR is the focus of this study. When an individual uses, either a cigarette or an…
ISEF · 2019
Cellular and Molecular Biology
The retrograde nuclear import is an important and conserved step in tRNA quality control in eukaryotes and is taken advantage of by retroviruses such as HIV to infect cells. Retrograde impor…
ISEF · 2019
Cellular and Molecular Biology
Glioblastoma multiforme is the most aggressive form of brain cancer (<5% of people diagnosed survive for longer than 5 years), with no specific treatment or prevention. For many types of can…
ISEF · 2019
Cellular and Molecular Biology Fourth Award
Melanoma, a tumor arising from melanocytes, is responsible for most skin cancer deaths. Familial melanoma is linked to germline mutations in the CDKN2A (p16) tumor suppressor gene, which reg…
ISEF · 2019
Cellular and Molecular Biology
If the effects of X-inactivation are observed with tortoiseshell cats, then it will be determined that lyonization is random and not predetermined because each female cell designates X chrom…
ISEF · 2018
Cellular and Molecular Biology Third Award
Migraines are the third most prevalent illness in the world, and migraine symptoms (e.g. severe pain, visual disturbances, nausea, and cognitive impairments) all impede daily life. At the ne…
ISEF · 2018
Cellular and Molecular Biology Fourth Award
While recent advances in gene therapy have reinforced the appeal for using Adeno-Associated Virus (AAV) for targeted gene delivery, the small genome delivery size limits the capabilities of…
ISEF · 2018
Cellular and Molecular Biology Fourth Award
The field of genetic engineering is rapidly developing with exciting new discoveries being made every day. However, existing gene editing technologies do not have perfect accuracy, and creat…
ISEF · 2018
Cellular and Molecular Biology Third Award
ABSTRACT Bumble bee (Bombus spp.) populations are declining nationally as well as globally due to a variety of factors including habitat loss, pathogens, and immune deficiencies. Because of…
ISEF · 2018
Cellular and Molecular Biology
Huntington’s disease(HD) is a fatal neurodegenerative disorder which affects around 1 in every 10,000 people. This autosomal dominant genetic disorder is caused by an expansion of the polygl…
ISEF · 2018
Cellular and Molecular Biology Second Award
Great advancements have been made in using adeno-associated virus (AAV) vectors for gene therapy; however, the basic biology behind AAV capsid assembly remains poorly characterized. Discover…
ISEF · 2018
Cellular and Molecular Biology
The VPS-34 gene in C. elegans is required for vesicular trafficking, including endocytosis, though the exact function of the protein is still unknown. My project involves identifying the spe…
ISEF · 2018
Cellular and Molecular Biology
In-vitro fertilization has been linked with a small but statistically significantly increased risk of mental retardation. With a such rapidly expanding field, that slight increased risk resu…
ISEF · 2018
Cellular and Molecular Biology
Drosophila Schneider 2 (S2) cells are commonly cryopreserved for long-term storage for use in biological and pharmaceutical product research. While fetal bovine serum (FBS) allows for higher…
ISEF · 2018
Cellular and Molecular Biology
The purpose of this study was to analyze the dietary patterns of Sea Lion predation on Salmonids. Salmon species are protected under the Endangered Species Act and Sea Lions are protected un…
ISEF · 2018
Cellular and Molecular Biology
Optogenetics is technique that uses light to regulate biological processes in living cells. It is based on genetically engineered proteins that are activated by light. Due to high spatial-te…
ISEF · 2018
Cellular and Molecular Biology
Purpose: Vessels, lined by endothelial cells (ECs), supply oxygen (O2) to our bodies. When tissues are devoid of enough O2, Hypoxia Inducible Factor (HIF) is stimulated to induce >200 genes…
ISEF · 2018
Cellular and Molecular Biology First Award
Though cell cycle regulation plays a key role in numerous developmental processes, including morphogenesis and differentiation, the regulatory systems that control the cell cycle remain poor…
ISEF · 2018
Cellular and Molecular Biology
This research broadens the understanding of the murine immune system in inflammatory bowel disease simulations, highlighting the presence of a newly classified cell group, Myeloid Derived Su…
ISEF · 2018
Cellular and Molecular Biology
The dynamic organization of the human genome is largely dependent on the nucleosome occupancy. Changes in nucleosome distribution allow access to the underlying DNA, and nucleosomes have bee…
ISEF · 2018
Cellular and Molecular Biology
The use of the electronic nicotine delivery system, also known as electronic cigarette (e-cig), is tremendously rising in young adults in the US. E-cigs are the most commonly used tobacco-re…
ISEF · 2018
Cellular and Molecular Biology
PDE inhibitors are frequently used as pharmaceuticals to treat conditions such as pulmonary diseases and erectile dysfunction via the cAMP dependent signaling pathway. However, PDE inhibitor…