38,465 real projects from ISEF, the Canada-Wide Science Fair, JSHS, AJAS, the Calgary Youth Science Fair and the California Science & Engineering Fair — searchable by meaning, and filterable by fair, year, category and award.
ISEF · 2021
Cellular and Molecular Biology Third Award
Down syndrome (DS) is the most common genetic disorder in humans. It is known that trisomy of chromosome 21 causes DS, but how this chromosomal gain produces the complex DS phenotype, includ…
ISEF · 2021
Cellular and Molecular Biology Fourth Award
Non-small cell lung carcinoma (NSCLC), accounting for the majority of lung cancer cases, has become a high-studied topic in the field of immunotherapeutics. While there are treatment options…
ISEF · 2021
Cellular and Molecular Biology
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder for which there is no cure. In 97% of sporadic ALS patients, TDP-43 forms insoluble protein aggregates dysregulating RNA m…
ISEF · 2021
Cellular and Molecular Biology
Carcass bruising from horns costs the cattle industry $10 million a year (Anderson, 2012). It is vital to develop safe and cost effective advancements in dehorning procedures. Removal of hor…
ISEF · 2021
Cellular and Molecular Biology
Hepatitis C virus (HCV) annually infects 2-3% of the world’s population. The infection causes numerous liver complications, but there is currently no vaccine against HCV. Even the antiviral…
ISEF · 2021
Cellular and Molecular Biology
The leukocyte human interferon alpha-2b is widely used for curing viral infection diseases and some types of cancer. Nowadays, the recombinant interferon is commonly produced in bacterial an…
ISEF · 2021
Cellular and Molecular Biology
Recent approaches in cancer immunotherapy revolve around encapsulating immunostimulatory molecules within nanoparticles and using systemic delivery to deliver them into the tumor, generating…
ISEF · 2021
Cellular and Molecular Biology Second Award
The CRISPR Cas9 Ribonucleoprotein (RNP) complex is well known for its precise gene editing abilities. Catalytically dead Cas9 (dCas9) also has diverse applications, including base editing, C…
ISEF · 2021
Cellular and Molecular Biology
Using Saccharomyces cerevisiae (baker's yeast) as a model organism, this research aims to study the Hog1 pathway in yeast and consequently mammalian homologous p38, which are SAPKs in contro…
ISEF · 2021
Cellular and Molecular Biology Third Award
Intragenomic conflict occurs when selfish genes attempt to increase their own prospects of replication at the expense of the organism. It has clinical and ecological significance–the genes a…
ISEF · 2021
Cellular and Molecular Biology
Parkinson’s disease (PD) is the second most common neurodegenerative disorder, affecting more than 6 million patients globally. Though previous studies have proposed several disease-related…
ISEF · 2021
Cellular and Molecular Biology
Small cell lung cancer (SCLC) is the most aggressive form of cancer with a 5-year survival rate of <7%. SCLC’s high mortality rate is attributed to early metastasis and treatment resistance.…
ISEF · 2021
Cellular and Molecular Biology
Communication is vital for all organisms to grow and exchange information, regardless organizational level of the organism. There are a growing number of studies that describe the different…
ISEF · 2021
Cellular and Molecular Biology Third Award
lnterleukin-22 (IL-22) is a regulatory cytokine in the IL-10 family. Numerous intestinal cell types including absorptive and secretory cells express IL-22RA1, the IL-22 receptor. Intestinal…
ISEF · 2021
Cellular and Molecular Biology
Alzheimer's disease (AD) is a progressive neurodegenerative disease that causes severe memory loss and neurodegeneration in humans. Two hallmarks of AD are amyloid-beta and tau proteins both…
ISEF · 2021
Cellular and Molecular Biology First Award
Mutated PTEN induced kinase 1 (PINK1) is linked to Parkinson’s disease, predisposing an individual to neurodegeneration. Interestingly, the FOXO, AOP, PNR, and TOR transcription factors have…
ISEF · 2021
Cellular and Molecular Biology
Antibiotic-resistant bacteria are a worldwide public health crisis with the potential of mass casualties due to the overuse of antibiotics. This experiment was conducted to investigate what…
ISEF · 2021
Cellular and Molecular Biology
Lung cancer is the leading cause of cancer-related mortality. Epithelial-mesenchymal transition (EMT), a process by which epithelial cancer cells acquire a mesenchymal phenotype, reportedly…
ISEF · 2021
Cellular and Molecular Biology
The constant increase in world population raises serious questions regarding our capacity to provide an adequate food source. In addition, the increasing demand for food, especially animal-b…
ISEF · 2020
Cellular and Molecular Biology
Adeno-Associated Virus (AAV) is an ideal vector for gene therapy, but it still has some challenges. Based on AAV, more efficient and more tissue-specific recombinant vectors are needed. In a…
ISEF · 2020
Cellular and Molecular Biology
Allorecognition, the process of recognizing tissue of self or close kin through genetic similarity, plays an important role in organ and graft transplant success because it can trigger rejec…
ISEF · 2020
Cellular and Molecular Biology
Quality control mechanisms exist throughout the gene expression pathway to ensure the accurate transmission of genetic information. Nonsense-mediated mRNA decay (NMD) is a translation-depend…
ISEF · 2020
Cellular and Molecular Biology
A new frontier in anti-aging research is the development of senolytics, drugs that selectively kill senescent cells an ameliorate age-associated disorders. A hallmark of senescence is the SA…
ISEF · 2020
Cellular and Molecular Biology
This research project identifies previously unknown vulnerabilities in pancreatic cancer cells that can be used to target cancer treatment. This research manipulates a step in the central do…
ISEF · 2020
Cellular and Molecular Biology
While at least eight Forkhead/Fox transcription factors are required for proper cardiac development in mammals and mutations in four Fox genes have been linked to human congenital heart dise…
ISEF · 2020
Cellular and Molecular Biology
Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by an expansion of the CAG tract in the huntingtin (HTT) gene. Oxidative stress (OS), or an abundance of oxidants in th…
ISEF · 2020
Cellular and Molecular Biology
Previous studies have shown that bacterial lipid droplets can bind to and protect DNA through MLDS proteins. The purpose of this study is to explore the binding ability of T4 phage DNA to li…
ISEF · 2020
Cellular and Molecular Biology
Cell polarity is the intrinsic asymmetry present in almost all eukaryotic cells shown in the organization of various subcellular components. Proper polarity is critical to cell division, mig…
ISEF · 2020
Cellular and Molecular Biology
Cancer therapeutics currently have the lowest clinical trial success rate of all major diseases. Partly from the paucity of successful anti-cancer drugs, cancer continues to be a leading cau…
ISEF · 2020
Cellular and Molecular Biology
Glioblastoma multiforme is the most aggressive form of brain cancer where <5% of patients live longer than 5 years. Metastatic cancer remains difficult to treat effectively and treatments ar…