Browse real student projects, abstracts, and awards.
ISEF · 2019
Cellular and Molecular Biology
Background: Traditional chemical-based treatments for disease are non-specific and cause undesirable side effects. These non-target effects can be avoided by site-specific, targeted therapy…
ISEF · 2019
Cellular and Molecular Biology Third Award
Gefitinib, which is a small molecule tyrosine kinase inhibitor (TKI) of epithelial growth factor receptor (EGFR), is currently under investigation for colon cancer treatment. However, some p…
ISEF · 2019
Cellular and Molecular Biology
This study examines epigenetic therapy as a treatment for slowing the growth of cancerous liver cells. More specifically, epigenetic changes such as the abnormal patterning of DNA hypo- and…
ISEF · 2019
Cellular and Molecular Biology
This experiment was designed not only from a continuation of a previous year, but as well as an improvement. Essential oils were present to prove that they have special and unique properties…
ISEF · 2019
Cellular and Molecular Biology
Angiogenesis is requisite for the growth and metastatic spread of solid tumors. Identifying pathological angiogenesis regulators will provide therapeutic targets against solid tumor growth.…
ISEF · 2019
Cellular and Molecular Biology
Currently, mutations in the BRCA1 and 2 genes are estimated to explain approximately 15 percent of hereditary breast cancer cases. However, studies have established that 50 percent of women…
ISEF · 2019
Cellular and Molecular Biology
Gastric cancer is one of the most common causes of cancer related deaths, yet little is known about the molecular drivers behind the progression of normal stomach to gastric cancer. GATA4 an…
ISEF · 2019
Cellular and Molecular Biology
Inhibitor of DNA binding 2, or Id2, is a protein that is required for hematopoietic stem cell (HSC) maintenance and self-renewal capacity. A positive feedback loop has been identified involv…
ISEF · 2019
Cellular and Molecular Biology
Over 70% of breast cancer patients’ cells express the estrogen receptor (ER), which promotes the proliferation of cancer cells, by activating the expression of tumor-promoting genes. In the…
ISEF · 2019
Cellular and Molecular Biology
Probiotic bacteria have been intensively studied for their role in the gut microbiome and digestion. Research into the abilities of probiotic bacteria to fight pathogens is also a growing ar…
ISEF · 2019
Cellular and Molecular Biology
Alzheimer’s is a progressive neurological disorder that affects memory and is the third leading cause of death. Downregulation of apolipoprotein E (ApoE) gene is involved in late-onset Alzhe…
ISEF · 2019
Cellular and Molecular Biology Third Award
Worldwide, stroke is the second leading cause of death and the third leading cause of disability. There is a striking lack of therapeutic interventions after the first few hours of stroke on…
ISEF · 2019
Cellular and Molecular Biology Fourth Award
Schizophrenia is a debilitating neurological disorder characterized by hallucinations, paranoia, and delusions. Identifying how schizophrenia specifically causes changes in the structure and…
ISEF · 2019
Cellular and Molecular Biology
The serine protease inhibitor-2 (Serp-2) gene is a virulence factor of the myxoma virus, an immunosuppressive disease found in European rabbits. This gene inhibits the proteases caspase-1 an…
ISEF · 2019
Cellular and Molecular Biology
The purpose of this research is to determine if isolating exosomes in urine and saliva can increase constancies in the capillary tube precipitation test. This, in turn, could diagnosis IgE s…
ISEF · 2019
Cellular and Molecular Biology
Current research suggests that toxic tau aggregates propagate from neuron to neuron in a prion-like manner. However, no dynamic proof exists to trace tau’s transmission and traffic in neurod…
ISEF · 2019
Cellular and Molecular Biology
Hypoxia (reduced oxygen) is common in many brain tumors, including gliomas. Hypoxia Inducible Factor 1 Alpha (Hif-1a) is upregulated and stabilized under hypoxic conditions, leading to tumor…
ISEF · 2019
Cellular and Molecular Biology
This research project seeks to analyze the characterization of the Human Epidermal Growth Factor Receptor (HER2) and the Dopamine Receptor D2 (DRD2) that is overexpressed in cancer cells. Th…
ISEF · 2019
Cellular and Molecular Biology
This project investigates the impact of Diethyl phthalate on cells of Allium cepa L, by measuring alterations in mitotic index, of the organism’s roots. The main factor that justifies this i…
ISEF · 2019
Cellular and Molecular Biology
Cells are composed of membraneless organelles that form through self-assembly of intrinsically disordered proteins (IDPs). These IDPs are thought to self-associate to form mesoscale protein…
ISEF · 2019
Cellular and Molecular Biology Fourth Award
During the progression of metastatic cancer, peripheral cells break away from the primary tumor and acquire the ability to intravasate into the circulatory and lymphatic systems. These invas…
ISEF · 2019
Cellular and Molecular Biology
Cancer cells have a homing ability and are able to track cells of their own kind. Because of this constant communication and close proximity, cancer cells could be used as targeted weapons t…
ISEF · 2019
Cellular and Molecular Biology
The goal of this research is to find a cure for cancer. Breast and Cervical cancers are very aggressive forms of cancer. Polyphenols, in green tea, have an anti-cancer effect. Phase I resear…
ISEF · 2019
Cellular and Molecular Biology
Stem cell therapy is a novel and promising strategy that shows strong potential to treat heart disease, particularly heart attacks (myocardial infarction) and heart failure. Stem cells are u…
ISEF · 2019
Cellular and Molecular Biology
Over the past decade, honey bee populations have been declining due to the phenomenon known as Colony Collapse Disorder (CCD). Nosema ceranae is a microsporidian parasite that has recently b…
ISEF · 2019
Cellular and Molecular Biology
Sterol regulatory element binding protein 1 (SREBP-1) is a master transcriptional regulator that controls the transcription of genes required for lipid and fatty acid production. Previous st…
ISEF · 2019
Cellular and Molecular Biology
In traditional Chinese medicine, sea cucumbers are commonly eaten to treat blood and kidney problems, which is why it was hypothesized that the sea cucumber species Holothuria cinerascens an…
ISEF · 2019
Cellular and Molecular Biology
Woody plants are important resources for paper productions, strategies for improvement of their properties are of considerable interest. The UP hybrid eucalyptus plants have fast-growth, goo…
ISEF · 2019
Cellular and Molecular Biology
Using different inhibitors to stop the cell cycle in different phases, we will see significant differences in DNA damage. In S-phase, we find DNA synthesizing, whereas in M-phase, DNA has co…
ISEF · 2019
Cellular and Molecular Biology
The purpose of this project was to compare fungal communities associated with soybean roots both before and after fungicide to identify unknown fungi that responds to fungicide application.…