Browse real student projects, abstracts, and awards.
ISEF · 2020
Cellular and Molecular Biology
The Apolipoprotein E (APOE) gene is the most influential genetic risk factor for Alzheimer’s Disease (AD). In addition to genotype, the implication of gender must also be investigated; women…
ISEF · 2020
Cellular and Molecular Biology
Almost one million people in the world will be diagnosed with a genetic kidney disease occurring in the collagen IV within the glomerular basement membrane (GBM). I wanted a less-complex viv…
ISEF · 2020
Cellular and Molecular Biology
Background: Alzheimer’s disease (AD) is one of the most debilitating neurological diseases leading to impairments in cognitive, sensory, and motor functions. Amyloid Aß plaques and neurofibr…
ISEF · 2020
Cellular and Molecular Biology
Current cancer therapies face significant challenges, such as inducing adverse patient side effects, having limited access to solid tissue tumours, or failing to target metastatic tumours. A…
ISEF · 2020
Cellular and Molecular Biology
How cells regulate and maintain their size is fundamentally unknown. Failure to maintain a consistent cell size has been associated with cardiac disease, brain disease, musculoskeletal disea…
ISEF · 2020
Cellular and Molecular Biology
Hypertension, a detriment linked to various risk factors, contributes to the development of renal and diabetic damage, increasing the risk for the development of cardiovascular disease, whic…
ISEF · 2020
Cellular and Molecular Biology
Schwannomatosis is a rare genetic disease characterized by pain and the development of peripheral nerve sheath tumors called schwannomas. Schwannoma in patients have mutations in the NF2 gen…
ISEF · 2020
Cellular and Molecular Biology
Acute Respiratory Distress Syndrome (ARDS) is a dangerous lung disease that reduces oxygen to the essential organs of the body. The treatment that patients with ARDS receive is a combination…
ISEF · 2020
Cellular and Molecular Biology
Adeno-associated viruses (AAV) are popular vectors for human gene therapy, yet their more efficacious use clinically is limited by an incomplete understanding of its virion assembly. More re…
ISEF · 2020
Cellular and Molecular Biology
Advances in artificial insemination techniques and semen handling have led to an increased rate of successful pregnancies and increased efficiency in large scale breeding programs. These tec…
ISEF · 2020
Cellular and Molecular Biology
Amyotrophic Lateral Sclerosis (ALS) is a devastating, neurodegenerative, adult-onset disorder, for which there is no known cure. In approximately 97% of sporadic ALS patients, a protein call…
ISEF · 2020
Cellular and Molecular Biology
To combat the rise in heart disease and resulting heart attacks, researchers have been looking into the use of stem cells as a possible treatment for these major medical issues. Following my…
ISEF · 2020
Cellular and Molecular Biology
The daf-2 and daf-16 genes have been highlighted for their reciprocal activity in altering longevity in the model organism Caenorhabditis elegans. Both daf-2 and daf-16 present orthologs in…
ISEF · 2019
Cellular and Molecular Biology
Norepinephrine (NE) and acetylcholine (ACh) mediate cell-to-cell communication in the central and peripheral nervous systems. Due to their importance in regulating many complex brain functio…
ISEF · 2019
Cellular and Molecular Biology Fourth Award
Aggregation of protein tau into neurofibrillary tangles and a-synuclein into Lewy bodies are hallmarks of Alzheimer’s and Parkinson’s disease, respectively. These proteins are known to form…
ISEF · 2019
Cellular and Molecular Biology
CRISPR is a rising gene editing technique that, although unprecedented in medical applications, has been found to cause unintentional edits that have fatal effects on an organism. In order t…
ISEF · 2019
Cellular and Molecular Biology
Arsenite contamination of source water presents a threat to dozens of developing countries that cannot afford remediatory solutions. The conversion of arsenite to arsenate via oxidation pres…
ISEF · 2019
Cellular and Molecular Biology
The extent of cell to cell communication between macrophages and tumor melanoma cells in mice was investigated. Two experiments were run. The first was an MTT assay which investigated whethe…
ISEF · 2019
Cellular and Molecular Biology Fourth Award
Abscission, the final stage of cytokinesis, is characterized by the separation of cells through the severing of the intercellular bridge at the midbody. Components of the Endosomal Sorting C…
ISEF · 2019
Cellular and Molecular Biology
Hydroxyurea (HU) is a ribonucleotide reductase inhibitor which is used to treat diseases such as HIV, sickle cell disease, and chronic myelogenous leukemia (1). Yet, new evidence suggests th…
ISEF · 2019
Cellular and Molecular Biology
Slime molds are single-celled organisms that combine interesting properties. We tested this organism’s reaction to a basic and anacidic environment. The slime mold Physarum polycephalum was…
ISEF · 2019
Cellular and Molecular Biology
Memory CD8 T cells are immune cells that eliminate diseased cells in the body. Recent approaches to treating chronic illnesses involve bolstering their immune responses to target abnormal ce…
ISEF · 2019
Cellular and Molecular Biology
The mountain lion (Puma concolor) is a large felid endemic to North and South America. Mountain lions were nearly extirpated across much of their range due to anthropogenic encroachment, hab…
ISEF · 2019
Cellular and Molecular Biology Third Award
Pancreatic adenocarcinoma(PDA) is one of the most malignant tumors, with an estimated 50,000 diagnoses and deaths per year. Current therapies have little effect on PDA due to the tumor’s lar…
ISEF · 2019
Cellular and Molecular Biology
Approximately 40% of the human genome is comprised of retrotransposons, which are genetic elements capable of amplifying themselves within the genome. Throughout the course of human life, re…
ISEF · 2019
Cellular and Molecular Biology Third Award
The challenge of finding the HIV cure lies in latent HIV-infected cells, which are inert to current HIV treatment. Since CD32a has been identified as a potential biomarker of latent HIV-infe…
ISEF · 2019
Cellular and Molecular Biology
The purpose of this research is to investigate which genetic mutations are responsible for Uveal Melanoma (UM), a rare subtype of melanoma but the most frequent primary cancer of the eye. Ge…
ISEF · 2019
Cellular and Molecular Biology
BACKGROUND: The androgen receptor (AR) is the driving force of prostate cancer growth. The AR is a nuclear receptor which, upon activation, goes to the nucleus and promotes transcription of…
ISEF · 2019
Cellular and Molecular Biology Fourth Award
Therapeutic targets for Ankylosing Spondylitis (AS) pathology are non-specific, and the cellular mechanisms that drive tissue proliferation in AS are poorly understood. This study investigat…
ISEF · 2019
Cellular and Molecular Biology Third Award
The enzyme Fidgetin-like 2 (FL2) suppresses cell migration by severing intracellular filaments called microtubules (MTs). Mouse studies showed that depleting FL2 using small interfering RNA…