38,465 real projects from ISEF, the Canada-Wide Science Fair, JSHS, AJAS, the Calgary Youth Science Fair and the California Science & Engineering Fair — searchable by meaning, and filterable by fair, year, category and award.
ISEF · 2026
Biomedical and Health Sciences Third Award
Impaired wound healing is a widespread complication experienced by diabetic patients, with persistent hyperglycemic conditions being a central factor that disrupts cellular repair programs.…
ISEF · 2026
Computational Biology and Bioinformatics Third Award
Despite decades of therapeutic development, most disease-associated proteins remain therapeutically inaccessible. These so-called “undruggable” targets typically lack suitable binding pocket…
ISEF · 2026
Computational Biology and Bioinformatics Third Award
Drug-induced liver injury (DILI) accounts for 13% of acute toxicity cases in the U.S. and remains a primary barrier to pharmaceutical development. While most machine learning models predict…
CSEF · 2026
Environmental Engineering (Track 2) (Senior Division) Third Award
Wildfires are becoming increasingly frequent and devastating, threatening lives, ecosystems, and infrastructure across the globe. The 2025 Los Angeles fires alone caused an estimated $250–27…
ISEF · 2026
Plant Sciences Third Award
Harmful agricultural practices have degraded topsoil and reduced organic matter, leaving farmers reliant on costly and damaging soil amendments. This threatens the ability to produce food fo…
CSEF · 2026
Mathematical Sciences (Junior Division) Third Award
In protein-coding DNA, 61 sense codons encode 20 standard amino acids, allowing multiple synonymous codons for the same protein sequence. Codon selection influences translation rate, ribosom…
ISEF · 2026
Microbiology Third Award
The bacterium Vibrio cholerae has evolved unipolar sheathed flagellum as the main organelle to drive motility and facilitate biofilm formation and colonization in host cells although the und…
ISEF · 2026
Animal Sciences Third Award
Drosophila melanogaster in quail farms poses a serious pest problem, where they disturb the birds, degrade hygiene, and reduce egg production, an important source of nutritious food globally…
CSEF · 2026
Medicine & Physiology (Junior Division) Third Award
Type 2 Diabetes (T2D) is rapidly increasing among youth (2M), and projected to surge by 700% in 2060. Current medical strategies are reactive, focusing on post diagnosis treatment. Motivated…
CSEF · 2026
Plant Biology (Junior Division) Third Award
Aphids are small insects that negatively impact varieties of plants and cause complications to a plant’s health such as stunting plant growth and causing discoloration. Aphids carry and tran…
CSEF · 2026
Earth & Environmental Sciences(Senior Division) Third Award
Ants, given their size, function as ecosystem engineers, which are critically essential to almost all terrestrial environments. However, whether intraspecific and interspecific conflict amon…
ISEF · 2026
Robotics and Intelligent Machines Third Award
Large language models (LLMs) achieve remarkable performance on complex reasoning tasks, yet they fail unpredictably and with high confidence on seemingly simple problems, posing a critical c…
ISEF · 2026
Biomedical Engineering Third Award
Assistive grasping of slippery, delicate, or thin objects remains challenging for hand-impaired individuals. Current prosthetic hands and soft grippers often rely on rigid linkages or bulky…
ISEF · 2026
Physics and Astronomy Third Award
Binary neutron star (BNS) mergers emit gravitational waves and eject neutron-rich matter, powering a short-lived infrared transient known as a kilonova. Immediately after the merger, the hyp…
ISEF · 2026
Microbiology Third Award
Burkitt's Lymphoma is an aggressive B-cell malignancy associated with Epstein-Barr virus (EBV) infection. Over 95% of the world's population is persistently infected by EBV. While current tr…
ISEF · 2026
Biomedical Engineering Third Award
In 2025, the American Cancer Society reported 2.1 million Americans were diagnosed with cancer, which is the leading cause for 1 in 6 deaths. This can largely be attributed to late diagnoses…
CSEF · 2026
Applied Mechanics (Junior Division) Third Award
This project addresses an inspection gap in structural monitoring because loosened connections or developing cracks can increase the risk of collapse. However, frequent vibration monitoring…
ISEF · 2026
Materials Science Third Award
Slips, Trips, and Falls (STFs) are major sources of accidents among various populations. About 38 mill falls happen each year in the US alone, with more than 50,000 associated with mobility…
ISEF · 2026
Translational Medical Science Third Award
Triple-negative breast cancer (TNBC) is one of the deadliest breast cancer subtypes because it lacks the receptors targeted by most therapies, leaving patients with few treatment options. Th…
ISEF · 2026
Robotics and Intelligent Machines Third Award
In fields such as exploration or inspection in hazardous environments, the ability to navigate terrain safely is crucial. This is often done through robotics; however, traditional systems (r…
CSEF · 2026
Electronics & Electromagnetics (Senior Division) Third Award
In fields such as rugged exploration or search and rescue, the ability to navigate terrain safely is crucial. This is often done through robotics; however, traditional systems (rovers, drone…
ISEF · 2026
Translational Medical Science Third Award
Diagnosing drug-resistant strains Mycobacterium tuberculosis (Mtb) is critical for informing treatment plans and limiting infections. However, existing diagnostics are slow and cover a narro…
ISEF · 2026
Biomedical Engineering Third Award
As humanity ventures beyond Earth, the challenges of space travel extend beyond rocket science and astrophysics. Astronauts face extreme physiological stress, and during deep-space missions…
ISEF · 2026
Robotics and Intelligent Machines Third Award
Large language models (LLMs) are increasingly trusted in domains such as education, research, and decision making. Despite their widespread adoption, fundamental questions remain about align…
ISEF · 2026
Cellular and Molecular Biology Third Award
KARS1 encodes bifunctional cytoplasmic and mitochondrial lysyl-tRNA synthetases, and biallelic loss-of-function variants cause infantile-onset progressive leukoencephalopathy (LEPID) and rel…
ISEF · 2026
Cellular and Molecular Biology Third Award
Ischemic injury causes neuronal loss and neurological deficits, challenging stroke recovery. After injury, a glial scar forms, but its regulation of neural stem cell (NSC) fate remains uncle…
ISEF · 2026
Biomedical Engineering Third Award
Major challenges exist in detecting infectious diseases early on as biomarker concentrations are often below the limit of detection (LoD) of conventional assays. This detection failure leads…
CSEF · 2026
Chemistry (Junior Division) Third Award
Lack of hard water purification solutions costs American corporations $25 billion annually due to extra energy usage, maintenance, and premature replacement. To support environmental sustain…
ISEF · 2026
Embedded Systems Third Award
Falls are the second leading cause of unintentional injury death worldwide, responsible for over 684,000 deaths annually. Existing solutions leave critical gaps. Preventive approaches like s…
ISEF · 2026
Physics and Astronomy Third Award
Current drug design methods treat proteins as rigid structures, failing to capture functional high-energy states. This contributes to 40–50% of clinical-stage drug failures. Mapping continuo…