ISEF · 2016
Highly Effective Hybrids
Fourth Award
Research and development on new forms of construction are important to the growth of infrastructure and manufacturing. Finding new materials that can not only be more cost effective than com…
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ISEF · 2016
Identification of Parkinson’s Disease-Associated SNP-SNP Interaction Using Interaction Analysis by Chi-Square (IAC)
Fourth Award
Parkinson’s disease (PD) is a progressive neurodegenerative disease that affects an estimated seven to ten million people worldwide. During the past ten years, Genome-Wide Association Studie…
ISEF · 2016
Identifying Greenhouse Gas Hotspots in Megacities
Fourth Award
Global warming due to the release of man-made greenhouse gases in our atmosphere continues to be a major challenge for scientists today. An accurate and efficient measurement strategy to est…
ISEF · 2016
Immobilization of Glycans on Silicon Substrates for Diagnostic Microarrays
Energy: Sustainable Materials and Design Fourth Award
Biochemical methods that enable rapid and early diagnosis are critical to disease and patient management. Of unequivocal importance to addressing these issues is the study of interactions be…
ISEF · 2016
Inexpensive, Portable Glucose Monitor for Diabetics via a Crosslinked Sensing Fluid
Fourth Award
Diabetes mellitus currently affects over 346 million people worldwide and is one of the leading causes of death. Current treatment requires frequent blood-glucose tests followed by necessary…
ISEF · 2016
Inhibition of Bacterial Mutagenesis through Polyubiquitination: A Solution to Antibiotic Drug Resistance
Fourth Award
Bacterial cells can have DNA damage due to transcriptional error, or through the effect of an antibiotic. The SOS response is a bacterial cell program for coping with DNA damage, in which th…
ISEF · 2016
Investigating Novel Bacteriophage Solutions as a Preventative Measure for Biofilm Formation in Medically Relevant Settings
Fourth Award
Bacteriophages have been known to be capable of eliminating deadly bacterial infections, but their use on biofilms in medical settings has been very limited. In this proof-of-principle inves…
ISEF · 2016
Investigating p16 Control of Mitochondrial Biogenesis in Melanoma
Fourth Award
Melanoma is the most dangerous type of skin cancer and its incidence has significantly increased in the past decade. Inherited mutations in CDKN2A, which encodes the p16 tumor suppressor, pr…
ISEF · 2016
Investigations into Cardiology: Categorizing Heart Rhythms using Machine Learning
Fourth Award
The purpose of this experiment was to create and test a computer model to accurately and automatically classify cardiac arrhythmias. Such a model, in the absence of trained cardiac professio…
ISEF · 2016
IP Intercom
Fourth Award
Our objective is to offer internal communication everywhere the organization needs it, with the possibility to grow to external communications, taking advantages of pre-existing infrastructu…
ISEF · 2016
Isolation and Characterization of Bacteriophages Effective at Killing Enterococcus faecalis
Fourth Award
The bacterium Enterococcus faecalis is a common source of hospital acquired infections due to its intrinsic resistance to cephalosporins. As antibiotics become less effective at preventing a…
ISEF · 2016
Late Stage Osteoarthritis Reveals Increased Expression of SQSTM1
Fourth Award
Osteoarthritis (OA) is a debilitating disorder affecting over 27 million adults in the United States; with the knee being the most commonly affected joint. During OA progression the articula…
ISEF · 2016
Lemnoideae: A Sustainable Bioremediation Treatment Targeting Eutrophication
Fourth Award
Eutrophication is a severe type of water pollution from excess nutrient inputs (NO3 and PO4). Many nations cannot maintain its expensive chemical treatments. Lemniodeae, a macrophyte known a…
ISEF · 2016
“Let There Be Light!” rAAV Mediated Delivery of shRNA in a Canine Model of Autosomal-dominant Retinitis pigmentosa
Biomedical Engineering Fourth Award
Autosomal-dominant Retinitis Pigmentosa (adRP) is caused by diverse gain-of-function mutations in rhodopsin (RHO). The purpose of this study is to aid in the development of a mutation-indepe…
ISEF · 2016
Leveraging the Antimicrobial Properties of Jatropha curcas in Suture Engineering
Fourth Award
Surgical site infections, SSI’s, are the leading type of infection in countries with limited resources, affecting up to 2/3 of operated patients with a frequency up to nine times higher than…
ISEF · 2016
Linked Fuzzy Inference System: A Novel Approach to Schizophrenia Diagnosis
Fourth Award
Schizophrenia is a mental disorder that affects the essence of what makes people human. It drastically alters a person's perception and actions until the patient becomes harmful to oneself o…
ISEF · 2016
lnvestigating Shear Thickening Fluid Applications to Decrease Linear and Rotational Mean Peak Acceleration as Measured by Dual Axis Accelerometers in Hockey Headgear and a Hybrid 3 Head Form
Fourth Award
Recently a new emphasis has been placed on protection headgear in hockey and other sports as the importance concussion and sub-concussive brain Injury has been better understood, A Summation…
ISEF · 2016
Logical Levitation: Achieving Magnetic Levitation via Computational Feedback Loop
Fourth Award
The purpose of my project was to attempt to create a device which would make invasive surgery less intrusive by removing the need for much of the physical dissection. I planned to accomplish…
ISEF · 2016
Loss of Fascin Enhances Nuclear Actin Filament Formation
Translational Medical Science Fourth Award
Nuclear actin, while still poorly understood, plays a role in DNA replication, chromatin organization, and gene expression. This research uses Drosophila oogenesis as a model to study in viv…
ISEF · 2016
Mechanism of Inactivation of Piezo Ion Channels
Translational Medical Science Fourth Award
Piezo proteins have been identified as key components of mechanosensitive ion channels in humans and other mammals. These channels are in the early stages of characterization; their mechanis…
ISEF · 2016
Metagenomics, Digital & qPCR Molecular Analysis of Bed-Time Oral Brushing
Fourth Award
Everybody knows that cleaning the oral cavity is good for oral hygiene. However, not everyone knows that during the night sleep, when our mouth doesn’t do saliva flushing, bacteria grows a l…
ISEF · 2016
Mimicking Robotic "Smart" Prosthetic Arm
Fourth Award
The age of robotics is upon us as we blast through the 21st century, our technology continues to increase exponentially. Rapid advancements in 3D printing is revolutionizing the world of eng…
ISEF · 2016
Misfolded alpha-synuclein: Assessment of Lactulose and Melibiose for Parkinson’s Disease
Fourth Award
Parkinson’s disease (PD) is a chronic central nervous system degenerative disease associated with resting tremor, bradykinesia, rigidity, and progressive degeneration of dopaminergic neurons…
ISEF · 2016
Molecular Dynamics Simulations of the NF-kB Inducing Kinase in Disease Prevention: The Structure-Function Relationship of the NIK protein and Its Effect on Cancer
Energy: Sustainable Materials and Design Fourth Award
Improper signaling of the nuclear factor-?B (NF-?B) pathway plays a critical role in many inflammatory disease states, including cancer, stroke, and viral infections. Although a majority of…
ISEF · 2016
mTOR Regulates the Phenotypic Modulation of De-differentiated Mesenchymal Stem Cells in Vascular Disease
Translational Medical Science Fourth Award
Atherosclerosis, a form of cardiovascular disease, accounts for 17.3 million deaths/year(Mozaffarian,2014). Characterized by plaque formation in arteries, it leads to myocardial infarctions…
ISEF · 2016
Mutants of Leucine Rich Receptor Like Kinase Proteins Show Increased Biomass: A Proteomic Study
Fourth Award
Cellulose synthase (CESA) complexes, which are essential for cellulose biosynthesis, are bridged to cortical microtubules that enable them to reach the cell wall by the CESA interactive prot…
ISEF · 2016
Nematicidal Activity and Saponin Concentration of Chenopod Extracts
Fourth Award
Nematodes cause significant economic losses in crop production throughout the world and can cause illness in humans and other mammals. The purpose of this study was to determine potential ef…
ISEF · 2016
Next Generation Fatty Acid Binding Protein Inhibitors: Computer-Aided Drug Design and Synthesis of Novel Truxillic Acid Diesters for Chronic Pain Inhibition
Energy: Sustainable Materials and Design Fourth Award
Demand for non-addictive, tissue-specific pain relief has been growing ever since the IOM confirmed that pain afflicts more Americans than cancer, heart disease, and diabetes combined. In ye…
ISEF · 2016
NOGOS: A Novel Nano-Oligosaccharide Doped Graphene Sand Composite Water Filter for Developing Countries
Fourth Award
A novel nano-oligosaccharide doped graphene sand composite filter (NOGOS) was created to serve as a simple, economical, and effective water filter in developing countries, where fresh water…
ISEF · 2016
Novel Approach to Antibiotics and Antifungals: Testing the Effectiveness of Azadirachta indica Extracts
Fourth Award
Preliminary research has shown that certain natural substances can be used without the fear of a new resistant strain developing. Thus, this project aims to determine the effectiveness of na…